Abstract
Complicating severe bacterial infection, sepsis is a clinical syndrome distinguished by systemic microvascular inflammation and widespread tissue injury. The incidence of sepsis is increasing as society ages and medical technologies expand. Sepsis is frequently manifested as multiple organ dysfunction syndrome (MODS) and the burden on resources of caring for these patients is substantial. An economic imperative can therefore be argued to improve our understanding of cause(s), consequences and rational treatment strategies for this syndrome.
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References
Bersten AD, Sibbald WJ (1989) Circulatory disturbances in multiple systems organ failure. In: Barbara Cohen (ed) Critical Care Clinics. W. B. Saunders, Philadelphia, pp 233–254
Nelson DP, Samsel RW, Wood LDH, Schumacker PT (1988) Pathological supply-dependency of systemic and intestinal uptake during endotoxemia. J Appl Physiol 64: 2410–2419
Daneck SJ, Lynch JP, Weg JG, Danzker DR (1990) The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syndrome. Am Rev Respir Dis 122: 387–395
Pape HC, Remmers D, Klemann W, Gors JA, Regel G, Tschern EH (1994) Posttraumatic multiple organ failure–A Report on clinical and autopsy findings. Shock 2: 228–234
Shoemaker WC, Appel PL, Gram HB, Waxmann K, Tai-Shion Lee (1988) Prospective trial of supranormal values of survivers as therapeutic goals in high risk surgical patients. Chest 94: 1176–1186
Wagner PD (1988) An integrated view ofthe determinants of maximum oxygen uptake. In: Gonzalez NC, Fredde MR (eds) Oxygen transfer from atmosphere to tissues. Plenum, New York, pp 245–256
Morisaki H, Sibbald W, Martin C, Doig G, Inman K (1996) Hyperdynamic sepsis depresses circulatory compensation to normovolemic anemia in conscious rats. J Appl Physiol 80: 656–664
Bloos FM, Morisaki HM, Neal AM, Martin CM, Elli CG, Sibbald WJ (1996) Sepsis depresses the metabolic oxygen reserve of the coronary circulation in mature sheep. Am J Respir Crit Care Med 153: 1577–1584
Schmidt RF, Thews G (eds) (1980) Physiologie des Menschen. 20. neu bearb. Aufl. Springer-Verlag, pp 522–526
Guyton AC, Hall JE (1996) Textbook of medical physiology, 9th edition. W. B. Saunders, Philadelphia, pp 43–55 and pp 501–511
Berne RM, Levy MN (1993) Physiology, 3rd edition. Mosby Year Book, pp 465–477
Snyder JV (1987) Oxygen transport: The model and reality. In: Snyder JV, Pinsky MR (eds) Oxygen transport in the critically ill. pp 3–15 and pp 153–164
Piiper J, Scheid P (1981) Model for capillary-alveolar equilibration with special reference to 02 uptake in hypoxia. Respir Physiol 46: 193–208
Saltin B (1985) Hemodynamic adaptations to exercise. Am J Cardiol 55: 42D - 47D
Rowell LB, Saltin B, Kiens B, Christensen NJ (1986) Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia? Am J Physiol 251: H1038 - H1044
Anderson P, Saltin B (1985) Maximal perfusion of skeletal muscle in man. J Physiol 366: 233–249
Dempsey J, Hanson P, Pegelow D, Claremont A (1982) Limitations to exercise capacity and endurance: Pulmonary system. Can J Appl Sport Sci 7: 4–13
Welch HG (1982) Hyperoxia and human performance: A brief review. Med Sci Sports Exercise 14: 253–262
Cain SM (1983) Peripheral oxygen uptake and delivery in health and disease. Clin Chest Med 4: 139–148
Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D (1994) Elevation of systemic oxygen in the treatment of critically ill patients. N Eng J Med 330: 1717–1722
Lam C, Tyml K, Martin C, Sibbald W (1994) Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94: 2077–2083
Farquhar IA, Lam C, Ellis C, Tyml K, Martin CM, Sibbald W (1997) Intravital microscopy of the mucosal microcirculation in sepsis. J Surg Res (In press)
Honig CR, Gayeski TEL Federspiel WJ, Clark A (1984) Muscle 02 gradients from hemoglobin to cytochrome: New concepts, new complexities. Adv Exp Med Biol 169: 23–38
Bebout DE, Hogan MC, Hempleman SC, Wagner PD (1993) Effects of training and immobilisation VO2 and DO2 in dog gastrognemius muscle in situ. J Appl Physiol 74: 1697–1703
Gonzalez NG, Erwig LP, Painter CF, Clancy RL, Wagner PD (1994) Effect of hematocrit on systemic 02 transport in hypoxic and normoxic exercise in rats. J Appl Physiol 77: 1341–1348
Gale GE, Torre-Bueno J, Moon RE, Saltzman HA, Wagner PD (1985) Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude. J Appl Physiol 58: 978–988
Schumacker PT, Kazaglis J, Conolly HV, Samsel RW, O’Connor MF, Umans JG (1995) Systemic and gut 02 extraction during endotoxemia: Role of nitric oxide synthase. Am J Respir Crit Care Med 151: 107–115
Wagner PD (1995) Limitations of oxygen transport to the cell. Intensive Care Med 21: 391–398
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Eichelbroenner, O., Bloos, F.M., Sibbald, W.J. (1997). O2 Transport in the Peripheral Circulation in Sepsis. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1997. Yearbook of Intensive Care and Emergency Medicine, vol 1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13450-4_25
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DOI: https://doi.org/10.1007/978-3-662-13450-4_25
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