SpringerLink
Log in

Multiple endokrine Neoplasien (MEN)

  • Chapter
Praxis der Viszeralchirurgie

  • 29 Accesses

Zusammenfassung

Die multiple endokrine Neoplasie Typ 1 (MEN-1-Syndrom oder Wermer-Syndrom), eine seltene autosomal dominante Erkrankung, ist durch das Auftreten von pathologischen Veränderungen innerhalb mehrerer endokriner Organsysteme charakterisiert. In über 90% geht sie mit einer Hyperplasie der Nebenschilddrüsen einher, wesentlich seltener sind Hypophysenvorderlappenadenome (45–60%), endokrine Pankreastumoren (30–80%), Nebennierenrindentumoren (15–34%) und andere neuroendokrine Tumoren (5–26%). Die Klinik des MEN-1-Syndroms richtet sich nach dem betroffenen endokrinen Organsystem. Ein genetisches Screening ermöglicht die Früherkennung betroffener Familienmitglieder von MEN-1-Patienten, sowie auch die Diagnosesicherung der Erbkrankheit bei Tumoren, die MEN-1-assoziiert auftreten können. Bei Genträgern wird ein jährliches biochemisches Screening empfohlen, um die frühzeitige Diagnose weiterer benigner oder maligner MEN-1-assoziierter endokriner Tumoren zu ermöglichen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
GBP 19.95
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
GBP 33.99
Price includes VAT (United Kingdom)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  • Anderson HO, Jorgensen P E, Bardram L, Hilstedt L (1990) Screening for multiple endocrine neoplasia type 1 in patients with recognized pituitary adenoma. Clinical Endocrinology 33: 771–775

    Article  Google Scholar 

  • Chandrasekharappa SC, Guru SC, Manickam P et al. (1997) Positional cloning of the gene for multiple endocrine neoplasia -type 1. Science 276: 404–407

    Article  PubMed  CAS  Google Scholar 

  • Chanson P, Cadiot G, Murat A (1997) Management of patients at risk for multiple endocrine neoplasia type 1: MEN 1. Horm Res 47: 211–220

    Article  PubMed  CAS  Google Scholar 

  • Corbetta S, Alessandro P, Peracchi M, Beck-Peccoz P, Faglia G, Spada A (1997) Multiple endocrine neoplasia type 1 in patients with recognized pituitary tumors of different types. Clin Endocrin 47: 507–512

    Article  CAS  Google Scholar 

  • Cupisti K, Dotzenrath C, Simon D, Goretzki PE, Röher HD (1997) Chirurgische Therapie neuroendokriner Tumoren des ‘Thymus. Chirurg 68: 136–140

    Article  PubMed  CAS  Google Scholar 

  • Goretzki PE, Höppner W, Dotzenrath C, Simon D, Schulte H, Röher HD (1998) Genetical and biochemical screening for endocrine disease. World J Surg 22: 1202

    Article  PubMed  CAS  Google Scholar 

  • Mignon M, Ruszniewski P, Podevin P, Sabbagh L, Cadiot G, Rigaud D, Bonfils S (1993) Current approach to the management of gastrinoma and insulinoma in adults with multiple endocrine neoplasia type I. World J Surg17: 489–497

    Google Scholar 

  • Skogseid B, Rastad B, ()berg K (1994) Multiple endocrine neoplasia type 1, clinical features and screening. Endo-crin Metab North America 23: 1–18

    CAS  Google Scholar 

  • Chandrasekharappa SC, Guru SC, Manickam P et al. (1997) Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276: 404–407

    Article  PubMed  CAS  Google Scholar 

  • Heppner C, Kester MB, Agarwal SK et al. (1997) Nat Genet 16: 375–378

    Article  PubMed  CAS  Google Scholar 

  • Larsson C, Shepherd J, Nakamura Y et al. (1992) Predictive testing for multiple endocrine neoplasia type 1 using DNA polymorphism, J Clin Invest 89: 1344–1349

    Article  PubMed  CAS  Google Scholar 

  • Siradanahalli CG, Goldsmith PK, Burns AL, Marx SJ, Spiegel AM, Collins FS, Chandrasekharappa SC (1998) Menin, the Product of the MEN 1 gene, is a nuclear protein. Proc Natl Acad Sci USA 95: 1630–1634

    Article  Google Scholar 

  • Thakker RV, Bouloux P, Wooding C et al. (1989) Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11. N Engl J Med 321: 218–224

    Article  PubMed  CAS  Google Scholar 

  • Zhuang Z, Vortmeyer AO, Pack S et al. (1997a) Somatic mutations of the MEN 1 tumor supressor gene in sporadic gastrinomas and insulinomas. Cancer Res 57: 4682–4686

    PubMed  CAS  Google Scholar 

  • Zhuang Z, Ezzat SZ, Vortmeyer AO et al. (1997b) Mutations of the MEN 1 tumor suppressor gene in pituitary tumors. Cancer Res 57: 5446–5451

    PubMed  CAS  Google Scholar 

  • Demeure MJ, Klonoff D, Karam JH et al. (1991) Insulinomas associated with multiple endocrine neoplasia type 1: the need for a different surgical approach. Surgery 110: 998–1003

    PubMed  CAS  Google Scholar 

  • Doherty GM, Olson JA, Frisella MM, Lairmore TC, Wells SA, Norton JA (1998). Lethality of multiple endocrine neoplasia type I. World J Surg 22: 581–587

    Article  PubMed  CAS  Google Scholar 

  • Dotzenrath C, Goretzki PE, Röher HD (1994a) Surgery of primary hyperparathyroidism in patients with multiple gland disease: the Düsseldorf experience. Acta Chir Austriaca Suppl 112: 47–49

    Google Scholar 

  • Dotzenrath C, Goretzki PE, Röher HD (1994b) Operative Strategie bei Persistenz und Rezidiv in der Chirurgie des primären Hyperprathyreoidismus. Langenbecks Arch Chir 379: 218–223

    Article  PubMed  CAS  Google Scholar 

  • Goretzki PE, Dotzenrath C, Röher HD (1991) Management of primary hyperparathyroidism caused by multiple gland disease. World J Surg 15: 693–697

    Article  PubMed  CAS  Google Scholar 

  • Jensen RT (1998) Management of the ZES in patients with multiple endocrine neoplasia type I. J Intern Med 243: 477–488

    Article  PubMed  CAS  Google Scholar 

  • Mignon M, Ruszniewski P, Podevin P, Sabbagh L, Cadiot G, Rigaud D Bonfils S (1993) Current approach to the management of gastrinoma and insulinoma in adults with multiple endocrine neoplasia type I. World J Surg 17: 489–497

    Article  PubMed  CAS  Google Scholar 

  • Mignon M, Cadiot G (1998) Diagnostic and therapeutic criteria in patients with Zollinger Ellison syndrome and multiple endocrine neoplasia type 1. J Intern Med 243: 489–494

    Article  PubMed  CAS  Google Scholar 

  • Proye C (1987) Surgical strategy in insulinoma of adults. Acta Chir Scand 153: 481

    PubMed  CAS  Google Scholar 

  • Riordain ODS, Brian OT, van Heerden, JA, Service FJ, Grant, CS (1994) Surgical management of insulinoma associated with multiple endocrine neoplasia type 1. World J Surg 18: 488

    Article  Google Scholar 

  • Rizzoli R, Green J, Marx SJ (1985) Primary Hyperparathyroidism in familial multiple endocrine neoplasia type 1. Am J Med 78: 467–474

    Article  PubMed  CAS  Google Scholar 

  • Röher HD, Simon D, Starke A, Goreztki PE (1997) Spezielle diagnostische and therapeutische Aspekte beim Insulinom. Chirurg 68: 116–121

    Article  PubMed  Google Scholar 

  • Skogseid B, Hberg K, Akerström G et al. (1998) Limited tumor involvemnet found at multiple endocrine neoplasia type 1 pancreatic exploration: Can it be predicted by preoperative tumor localisation? World J Surg 22: 673–678

    Article  PubMed  CAS  Google Scholar 

  • Thompson NW (1998) Current concepts in the surgical management of multiple endocrine neoplasia type I pancreatic duodenal disease. Results in the treatment of 40 patients with ZES, hypoglycemia or both. J Intern Med 243: 495–500

    Article  PubMed  CAS  Google Scholar 

  • Thompson NW, Bondeson AG, Bondeson L, Vinik A (1989) the surgical treatment og gastrinoma in MEN-1-syndrom patients. Surgery 106: 1108

    Google Scholar 

  • Thompson NW (1997) Pancreatic Surgery for Endocrine Tumors. In: Clark OH, Duh OY (eds) Textbook of endocrine surgery. Sanders, Philadelphia, USA

    Google Scholar 

  • Wells SA, Farndon JR, Dale JK, Leight GS, Dilley WG (1980) Long-tern evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation. Ann Surg 192 /4: 451–458

    Article  PubMed  Google Scholar 

  • Wilkinson S, Teh BT, Davey KR, McArdle JP, Young M, Sheohard JJ (1993) Cause of death in multiple endocrine neoplasia. Arch Surg 128: 683–690

    Article  PubMed  CAS  Google Scholar 

  • Brunt LM, Wells SA Jr (1987) Advances in the diagnosis and treatment of medullary thyroid carcinoma. Surg Clin North Am 67: 263–279

    PubMed  CAS  Google Scholar 

  • Donis-Keller H, Dou S, Chi D et al. (1993) Mutations in the RET proto-oncogene are associated with MEN 2a and FMTC. Hum Mol Genet 2: 851–856

    Article  PubMed  CAS  Google Scholar 

  • Evans DB, Lee JE, Merrell RC, Hickey RC (1994) Adrenal medullary disease in multiple endocrine neoplasia type 2. Endocrinol Metab Clin North Am 23: 167–176

    Google Scholar 

  • Farndon JR, Leight GS, Dilley WG, Baylin SB, Smallridge RC, Harrison TS, Wells SA (1986) Medullary thyroid carcinoma without associated endocrinopathies: a distinct clinical entity. Br J Surg 73: 278–281

    Article  PubMed  CAS  Google Scholar 

  • Frilling A (1993) Screening-Untersuchungen beim C-ZellKarzinom der Schilddriise. Thieme, Stuttgart New York

    Google Scholar 

  • Frilling A, Dralle H, Eng C, Raue F, Broelsch CE (1995) Presymptomatic DNA screening in families with multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. Surgery 118: 1099–1104

    Article  PubMed  CAS  Google Scholar 

  • Gagel RF, Tashijan AH Jr, Cummings T et al. (1988) The clinical outcome of prospective screening for multiple endocrine neoplasia type 2a. An 18-year experience. N Engl J Med 318: 478–484

    Article  PubMed  CAS  Google Scholar 

  • Hofstra RMW, Landsvater RM, Ceccherini I et al. (1994) A mutation in the RET-proto-oncogene associated with multiple endocrine neoplasia type 2b and sporadic medullary thyroid carcinoma. Nature 367: 375–376

    Article  PubMed  CAS  Google Scholar 

  • Howe JR, Norton JA, Wells SA (1993) Prevalence of pheochromocytoma and hyperparathyroidism in multiple endocrine neoplasia type 2a: Results of long-term follow-up. Surgery 114: 1070–1076

    Google Scholar 

  • Mallette LE (1994) Nlanagement of hyperparathyroidism in the multiple endocrine neoplasia syndromes and other familial endocrinopathies. Endocrinol Metab Clin North Am 23: 19–36

    PubMed  CAS  Google Scholar 

  • Melvin KEW, Miller HH, Tashjian AHJ (1971) Early diagnosis of medullary carcinoma of the thyroid gland by means of calcitonin assay. N Engl J Med 285: 1115–1120

    Article  PubMed  CAS  Google Scholar 

  • Mulligan LM, Kwok JBJ, Healey CS et al. (1993) Germ-line mutations of the RET Proto-Oncogen in multiple endocrine neoplasia type 2a. Nature 363: 458–460

    Article  PubMed  CAS  Google Scholar 

  • Mulligan LM, Marsh DJ, Robinson BG et al. (1995) Genotype-phenotype correlation in MEN: report of the International RET Mutation Consortium. J Intern Med 238: 343–346

    Article  PubMed  CAS  Google Scholar 

  • Ponder BAJ, Finer N, Coffey R et a1. (1988 b) Family screening in medullary thyroid carcinoma presenting without a family history. Quart J Med 252: 299–308

    Google Scholar 

  • Ponder BAJ, Coffey R, Gagel RF et al. (1988 a) Risk estimation and screening in families of patients with medullary thyroid carcinoma. Lancet 1: 397–401

    Google Scholar 

  • Raue F, Kotzereke J, Reinwein D et al. (1993) Prognostic factors in medullary thyroid carcinoma: evaluation of 741 patients from the German Medullary Thyroid Carcinoma Register. Clin Investig 71: 7–12

    Article  PubMed  CAS  Google Scholar 

  • Samaan NA, Draznin MB, Halpin RE, Bloss RS, Hawkins E, Lewis RA (1991) Multiple endocrine syndrome type IIb in early childhood. Cancer 68: 1832–1834

    Article  PubMed  CAS  Google Scholar 

  • Schimke RN, Hartmann WH, Prount TE, Rimoin DL (1968) Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma, and multiple neuromas. N Engl J Med 279: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Sipple H (1961) The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31: 163–166

    Article  Google Scholar 

  • Telander RL, Zimmerman D, Sizemore GW, van Heerden JA, Grant CS (1989) Medullary carcinoma in children. Results of early detection and surgery. Arch Surg 124: 841–843

    Google Scholar 

  • Telenius-Berg M, Berg B, Hamberger B, Tibblin S, Tisell L-E, Ysander 1., Weland G (1984) Impact of screening on prognosis in the multiple endocrine neoplasia type 2 syndromes: natural history and treatment results in 105 patients. Henry Ford Hosp Med J 32: 225–232

    CAS  Google Scholar 

  • Thakker RV, Ponder BAJ (1988) Multiple endocrine neoplasia. Baillier’s Clin Endocrin Metab 2: 1031–1067

    Article  CAS  Google Scholar 

  • Vasen FIFA, Nieuwenhuijzen AC, Berkel H et al. (1987) Multiple endocrine neoplasia syndrome type 2: The value of screening and central registration. A study of 15 kindredc in the Netherlands. Am J Med 83: 847–852

    Article  PubMed  CAS  Google Scholar 

  • Wells SA Jr, Chi DD, Tosshima K et al. (1994) Predictive DNA testing and prophylactic thyroidectomy in pateints at risk for multiple endocrine neoplasia type 2a. Ann Surg 220: 237–250

    Article  PubMed  Google Scholar 

  • Wells SA, Dilley WG, Farndon JA, Leight GS, Baylin SB (1985) Early diagnosis and treatment of medullary thyroid carcinoma. Arch Intern Med 145: 1248–1252

    Article  PubMed  Google Scholar 

  • Berndt I, Reuter M, Sailer B et al. (1998) A new hot spot for mutations in the RET proto-oncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A. J Clin Endocrinol Metab 83: 770–774

    Article  PubMed  CAS  Google Scholar 

  • Donis-Keller H, Doti S, Chi D et al. (1993) Mutations in the RET proto-oncogene are associated with MEN 2a and FMTC. Hum Mol Genet 2: 851–856

    Article  PubMed  CAS  Google Scholar 

  • Eng C, Smith DP, Mulligan LM et al. (1996) The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. DAMA 276: 1575–1579

    CAS  Google Scholar 

  • Frank-Raue K, Höppner W, Frilling A et al. (1996) Mutations of the ret proto-oncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype. J Clin Endocrinol Metabol 81: 1780–1783

    Google Scholar 

  • Gimm O, Marsh DJ, Andrew SD et al. (1997) Germline dinucleotide mutation in codon 883 of the RET protooncogene in multiple endocrine neoplasia type 2b without codon 918 mutation, J Clin Endocrinol Metab 82: 3902–3904

    Article  PubMed  CAS  Google Scholar 

  • Hofstra RMW, Landsvater RM, Ceccherini I et al. (1994), A mutation in the RET proto-oncogene associated with endocrine neoplasia type 2b and sporadic thyroid carcinoma. Nature 367: 375–376

    Article  PubMed  CAS  Google Scholar 

  • Ito S, Iwashita T, Asai N, Mukarami H, Iwata Y, Sobue G, Takahashi M (1997) Biological properties of RET with cysteine mutations correlate with multiple endocrine neoplasia type 2a, familial medullary thyroid carcinoma and Hirschsprung’s disease phenotype. Cancer Research 57: 2870–2872

    PubMed  CAS  Google Scholar 

  • Komminnoth P (1997) The RET proto-oncogene in medullary and papillary thyroid carcinoma. Molecular features, pathophysiology and clincal implications. Virchows Arch 431: 1–9

    Article  Google Scholar 

  • Mulligan LM, Kwok JB, Healey CS (1993) Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2a. Nature 363: 458–60

    Article  PubMed  CAS  Google Scholar 

  • Santoro M, Carlomagno F, Romano A et al. (1995) Activation of RET as a dominant transforming gene by germ mutations of MEN 2a and MEN 2b. Science 267: 381–383

    Article  PubMed  CAS  Google Scholar 

  • Smith DP, Houghton C, Ponder BA (1997) Germline mutation of RET codon 883 in two cases of de novo MEN 2b. Oncogene 15: 1213–1217

    Article  PubMed  CAS  Google Scholar 

  • Trupp M, Arena E, Fainzilber M et al. (1996) Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381: 785–789

    Article  PubMed  CAS  Google Scholar 

  • van Heyningen V (1994) One gen–four syndromes. Nature 367: 319–320

    Article  PubMed  Google Scholar 

  • Dralle H, Gimm O, Simon D et al. (1998) Prophylactic thyroidectomy in 75 children and adolescents with hereditary medullary thyroid carcinoma: german and Austrian experience. World J Surg 22: 744–751

    Article  PubMed  CAS  Google Scholar 

  • Evans DB, Lee JE, Merrell RC, Hickey RC (1994) Adrenal medullary disease in multiple endocrine neoplasia type 2. Endocrinol Metab Clin North Am 23: 167–176

    PubMed  CAS  Google Scholar 

  • Grant CS (1997) Pheochromocytoma. In: Clark OH, Duh Q-Y (ed) Textbook of endocrine surgery. WB Saunders Company, Philadelphia London Toronto Montreal Sydney Tokyo, pp 513–522

    Google Scholar 

  • Howe JR, Norton JA, Wells SA (1993) Prevalence of pheochromocytoma and hyperparathyroidism in multiple endocrine neoplasia type 2a: Results of long-term follow-up. Surgery 114: 1070–1076

    Google Scholar 

  • Kraimps JL, Barbier J (1997) Familial hyperparathyreoidism in multiple endocrine neoplasia syndromes. In: Clark OH, Duh Q-Y (ed) Textbook of endocrine surgery WB Saunders Company, Philadelphia London Toronto Montreal Sydney Tokyo, pp 381–384

    Google Scholar 

  • Mallette LE (1994) Management of hyperparathyroidism in the multiple endocrine neoplasia syndromes and other familial endocrinopathies. Endocrinol Metab Clin North Am 23: 19–36

    PubMed  CAS  Google Scholar 

  • Snow KJ, Boyd III AE (1994) Management of individual tumor syndromes. Endocrinol Metab Clin North Am 23: 157–166

    PubMed  CAS  Google Scholar 

  • Wells SA Jr, Chi DD, Tosshima K et al. (1994) Predictive DNA testing and prophylactic thyroidectomy in pateints at risk for multiple endocrine neoplasia type 2a. Ann Surg 220: 237–250

    Article  PubMed  Google Scholar 

  • Andrykowski MA, Munn RK, Studts JL (1996) Interest in learning of personal genetic risk for cancer: a general population survey. Prey Med 25: 527–536.

    Article  CAS  Google Scholar 

  • Audrain J, Rimer B, Cella D et al. (1998) Genetic counseling and testing for breast-ovarian cancer susceptibility: what do women want? J Clin Oncol 16: 133–138

    PubMed  CAS  Google Scholar 

  • Baum A, Friedman AL, Zakowski SG (1997) Stress and genetic testing for disease risk. Health Psychol 16: 8–19

    Article  PubMed  CAS  Google Scholar 

  • Bennett RL, Steinhaus KA, Ulrich SB et al. (1995) Recommendations for Standardized Human Pedigree Nomenclature. J Genet Couns 4: 267–280

    Article  Google Scholar 

  • Codori AM, Petersen GM, Boyd PA, Brandt J, Giardiello FM (1996) Genetic testing for cancer in children: short-term psychological effect. Arch Pediatr Adolesc Med 150: 1131–1138

    Article  PubMed  CAS  Google Scholar 

  • Conte-Devolx B, Schuffenecker I, Niccoli P et al. (1997) Multiple endocrine neoplasia type 2: management of patients and subjects at risk. French Study Group on Calcitonin-Secreting Tumors ( GETC ). Horm Res 47: 221–226

    Google Scholar 

  • Eng C (1996a) Seminars in medicine of the Beth Israel Hospital, Boston. The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung’s disease. N Engl J Med 335: 943–951

    Article  PubMed  CAS  Google Scholar 

  • Eng C, Clayton D, Schuffenecker I, Lenoir G et al. (1996b) The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine

    Google Scholar 

  • neoplasia type 2. International RET mutation consortium analysis. JAMA 276: 1575–1579

    Google Scholar 

  • Grosfeld FJM, Lips CJM, Beemer FA, van Spijker HG, Brouwers-Smalbraak GJ, Kroode HF (1997) Psychological risks of genetically testing children for a hereditary cancer syndrome. Patient Educ Couns 32: 63–67

    Article  PubMed  CAS  Google Scholar 

  • Julian Reynier C, Eisinger F, Vennin P et al. (1996) Attitudes towards cancer predictive testing and transmission of information to the family. J Med Genet 33: 731–736

    Article  PubMed  CAS  Google Scholar 

  • Love RR, Evans AM, Josten DM (1985) The accuracy of patient reports of a family history of cancer. J Chronic Dis 38: 289–293

    Article  PubMed  CAS  Google Scholar 

  • Mazur DJ, Hickam DH (1991) Patients’ interpretations of probability terms. J Gen Intern Med 6: 237–240

    Article  PubMed  CAS  Google Scholar 

  • Mazur DJ, Hickam DH (1994) The effect of physician’s explanations on patients’ treatment preferences: five-year survival data. Med Decis Making 14: 255–258

    Article  PubMed  CAS  Google Scholar 

  • Michie S, Marteau TM, Bobrow M (1997) Genetic counselling: the psychological impact of meeting patients’ expectations. J Med Genet 34: 237–241

    Article  PubMed  CAS  Google Scholar 

  • Richtlinienkommission der Ärztekammer (1998) Richtlinien zur Diagnostik der genetischen Disposition für Krebserkrankungen. Deutsches Ärzteblatt 95B: 1121–1127

    Google Scholar 

  • Task Force on Genetic Testing (1997) Promoting safe and effective genetic testing in the United States. In: Holtzman NA, Watson MS (eds) National Institutes of Health, Bethesda, MD. http://www.nhgri.nih.gov

Download references

Authors
  1. C. Dotzenrath
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Dralle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Frilling
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Goretzki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. Höppner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Rehder
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H. Rieder
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Chirurgische Klinik, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    J. R. Siewert

  2. Departement für Chirurgie, Kantonsspital, Spitalstraße 21, 4031, Basel, Schweiz

    F. Harder

  3. Klinik für Allgemeinchirurgie, Zentrum für Operative Medizin, Baldingerstraße, 35042, Marburg, Deutschland

    Matthias Rothmund

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dotzenrath, C. et al. (2000). Multiple endokrine Neoplasien (MEN). In: Siewert, J.R., Harder, F., Rothmund, M. (eds) Praxis der Viszeralchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09422-8_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-09422-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09423-5

  • Online ISBN: 978-3-662-09422-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation