Abstract
In normal people, autoreactive T cells can be deleted, either in the thymus or in the periphery, following presentation of self-peptides by host antigenpresenting cells (APCs) to self-reactive T cells (Kurts et al. 1996, 1998a,b). Breakdown in this putative tolerance mechanism is believed to contribute to autoimmunity in genetically susceptible individuals. Type I diabetes mellitus is characterized by infiltration of the islets of Langerhans by immune cells, which ultimately destroy the insulin-producing β-cells by T cellmediated mechanisms. The T cell-mediated nature of this autoimmunity requires that APCs not only have to present islet antigen released from β-cells but also have to deliver signals that promote survival of the self-reactive T cells. Identification of the cells and events that initiate and maintain this anti-islet inflammatory response is vital in the development of therapeutic strategies towards diabetes.
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Flavell, R.A. (2002). The Relationship of Inflammation and Initiation of Autoimmune Disease: Role of TNF Super Family Members. In: Cooper, M.D., Koprowski, H. (eds) The Interface Between Innate and Acquired Immunity. Current Topics in Microbiology and Immunology, vol 266. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-04700-2_1
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DOI: https://doi.org/10.1007/978-3-662-04700-2_1
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