Abstract
The value of synthetic organic chemistry to our understanding of the action of hypotensive peptides, and other biologically active peptides, has been well demonstrated. For example, the structure of bradykinin was originally established not only by degradative procedures (Elliott et al., 1960) but also by synthesis (Boissonnas et al., 1960). Through further synthetic work on bradykinin (Nicolaides and De Wald, 1961; Guttmann et al., 1962), kallidin (Nicolaides et al., 1961; Pless et al., 1962), methionyl-lysyl-bradykinin (Schröder, 1964; Merrifield, 1964b), eledoisin (Sandrin and Boissonnas, 1962), and physalaemin (Bernardi et al., 1964b), these peptides have become readily available for pharmacological investigations. In addition, large numbers of analogs of the active peptides have been prepared (Bernardi et al., 1964a; Schröder and Hempel, 1964), which have been valuable for studies of the effect of changes in chemical structure on biological activity.
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Merrifield, R.B. (1966). Automated Peptide Synthesis. In: Erdös, E.G., Back, N., Sicuteri, F., Wilde, A.F. (eds) Hypotensive Peptides. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-94965-4_1
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DOI: https://doi.org/10.1007/978-3-642-94965-4_1
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