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Two Highly Polymorphic VNTR Loci D5S110 (LH1) and D4S139 (Ph30): Analysis, Formal and Population Genetic Data

  • Conference paper
16th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.), Santiago de Compostela, 12–16 September 1995

Part of the book series: Advances in Forensic Haemogenetics ((HAEMOGENETICS,volume 6))

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Summary

The experimental technique is described that enable RFLP ty** with the two hypervariable VNTR loci D5S110 (LH1) and D4S139 (pH30). Population and formal genetic studies were performed using Haelll restricted DNA from 450 unrelated individuals (SW-Germany) and 35 families with 172 children (NW-Portugal). Both loci reveal more than 70 alleles ranging between 0.8 kb and 9.5 kb at D5S110 (LH1) and between 1,5 kb and 19.5 kb at D4S139 (pH30). In 172 méioses analysed, one recombination event was observed at the D4S139 locus (recombination frequency of 0.0058) and none at the locus D5S110. Allele frequency distributions were determined for each of the two loci. Heterozygosity calculation results in 93.01% for LH1 and 96.62% for ph30.

The findings show that these loci represent further genetic markers which are very informative for identity tests as well as for parentage analysis.

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Author information

Authors and Affiliations

  1. Inst. f. Anthroplogie und Humangenetik, Wilhelmstr. 27, 72074, Tübingen, Germany

    C. Luckenbach, A. Luckenbach, M. Mainka, J. Jung & H. Ritter

  2. Inst. Anthropologia, Universidade Porto, 4000, Porto, Portugal

    V. Almeida

Authors
  1. C. Luckenbach
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  2. A. Luckenbach
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  3. V. Almeida
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  4. M. Mainka
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  5. J. Jung
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  6. H. Ritter
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Editor information

Editors and Affiliations

  1. Institute of Legal Medicine, University of Santiago de Compostela, c/San Francisco s/n, E-15705, Santiago de Compostela, Spain

    Angel Carracedo

  2. Institut für Rechtsmedizin, Universität Münster, Von-Esmarch-Straße 86, D-48149, Münster, Germany

    Bernd Brinkmann

  3. Institute for Legal Medicine, University of Zurich, Winterthurerstraße 190, CH-8057, Zurich, Switzerland

    Walter Bär

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© 1996 Springer-Verlag Berlin Heidelberg

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Luckenbach, C., Luckenbach, A., Almeida, V., Mainka, M., Jung, J., Ritter, H. (1996). Two Highly Polymorphic VNTR Loci D5S110 (LH1) and D4S139 (Ph30): Analysis, Formal and Population Genetic Data. In: Carracedo, A., Brinkmann, B., Bär, W. (eds) 16th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.), Santiago de Compostela, 12–16 September 1995. Advances in Forensic Haemogenetics, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80029-0_174

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  • DOI: https://doi.org/10.1007/978-3-642-80029-0_174

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60492-1

  • Online ISBN: 978-3-642-80029-0

  • eBook Packages: Springer Book Archive

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