Abstract
For the last few years, we have been Interested in the interactions between oxygen free radicals (OFR) and the heat shock, or stress response. Oxidative injury participates in a variety of pathological conditions such as inflammation and ischemia. During inflammation, OFR are generated by the phagocytic cells (polymorphonuclear leukocytes, monocytes-macrophages) infiltrating the inflamed tissues, whereas after ischemia and during reperfusion, OFR are generated by a xanthine-xanthine oxidase system. In vitro, we have investigated in human monocytes-macrophages the effects of exogenous addition, as well as of endogenous production (during phagocytosis) of OFR. These cells respond to oxidative injury by the synthesis of the classical heat shock proteins (HSPs) and of oxidation-specific stress proteins such as heme oxygenase or superoxide dismutase (SOD). HSPs may thus be part of a physiological response to injury during inflammation. In animal models, HSPs are induced during reperfusion injuiy in the ischemic organs.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Aruoma, OI, Halliwell, B and Dizdaroglu, M, (1989) Iron ion-depedent modification in bases in DNA by superoxide radical-generating system hypoxanthine/xanthine oxidase. J. Biol. Chem., 264: 13024–13028.
Atkinson, BG, Blaker, TW, Tomlinson, J and Dean, RL, (1990) Ferritin is a translationally regulated heat shock protein of avian reticulocytes. J. Biol. Chem., 265: 14156–14162.
Barbe, MF, TVtell, M, Gower, DJ and Welch, WJ, (1988) Hyperthermia protects against light damage in the rat retina. Science, 241: 1817–1820.
Cerutti, PA (1989) Mechanisms of action of oxidant carcinogens. Cancer Detection and Prevention, 14: 281–284.
Christman, MF, Morgan, RW, Jacobson, FS and Ames, BN, (1985) Positive control of a regulon for defenses against oxidative stress and some heat shock proteins in Salmonella typhimurium. Cell, 41: 753–762.
Clerget, M and Polla, BS, (1990) Eiythrophagocytosis induces heat shock protein synthesis by human monocytes-macrophages. Proc. Natl. Acad. Sci. USA 87: 1081–1085.
Crawford, D, Zbinden, I, Amstad, P and Cerutti, P, (1988) Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells. Oncogene, 3: 27–32.
Curnutte, JT, Whitten, DM and Babior, BM, (1974) Defective superoxide production by granulocytes from patients with chronic granulomatous disease. N. Engl. Med., 290: 593–597.
Dillmann, WH, Mehta, HB, Barrieux, A Guth, BD, Neeley, WE and Ross, J Jr, (1986) Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat- shock/stress protein 71. Circulation Res., 59: 110–114.
Donati, YRA Kantengwa, S and Polla, BS, Phagocytosis and heat shock response in human monocytes-macrophages. Pathobiol., in press.
Duff, GW and Durum, SK, (1983) The pyrogenic and mitogenic actions of interleukin-1 are related. Nature, 304: 449–451.
Fantone, JC and Ward, PA (1982) Role of owgen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am. J. Pathol., 107: 397–418.
Forsdyke, DR, (1985) Heat shock proteins defend against intracellular pathogens: a non immunological basis for self /nonself discrimination? J. Theor. Biol., 115: 471–473.
Galvan, L, Huang, CH, Prestayko, AW, Stout, JT, Evans, JE and Crooke, ST, (1989) Inhibition of bleomycin-induced DNA breakage by superoxide dismutase. Cancer Res., 41: 5103–5106.
Halliwell, B, (1987) Oxidants and human disease: some new concepts. FASEB J., 1: 358–364.
Helqvist, S, Hansen, BS, Johannesen, J, Andersen, HU, Nielsen, JH and Nerup, J, (1989) Interleukin 1 induces new protein formation in isolated rat islets of Langerhans. Acta Endocrinol. ( Copenh ), 121: 136–140.
Hightower, LE and Wnite, FP, (1981) Cellular response to stress: comparison of a family of 71-73-kilodalton proteins rapidly synthesized in rat tissue slices ana canavanine-treated cells in culture. J. Cell Physiol., 108: 261–275.
Higo, H, Lee, JY, Satow, Y and Higo, K, (1989) Elevated expression of proto- oncogenes accompanies enhanced induction of heat-shock genes after exposure of rat embryos in utero to ionizing irradiation. Teratogen Carcinogen Mutagen, 9: 191–198.
JSMtela, M, Saksela, Kand Saksela, E, (1989) Heat-shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factor a and p. Eur. J. Immunol., 19: 1413–1417.
Kantengwa, S, Capponi, AM, Bonventre, JV and Polla, BS, (1990) Calcium and the heat shock response in the human premonocytic line U937: effects of 1,25-dihydroxyvitamin D3. Am. J. Physiol., 259 (Cell Physiol 28): C77 - C83.
Kantengwa, S, Donati, RYA, Clerget, M, Maridonneau-Parini, I, Sinclair F, Mariethoz, E, Rees, ADM, Slosman, DO and Polla, BS, Heat shock proteins: an autoprotective mechanism for inflammatory cells. Sem. Immunol, in press.
Kaur, P, Welch, WJ and Saklatvala, J, (1989) Interleukin 1 and tumor necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells. FEBS, 258: 269–273.
Keyse, SM and Tyrrell, RM, (1987) Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal skin fibroblasts. J. Biol. Chem., 262: 14821–14825.
Keyse, SM and Tyrrell, RM, (1989) Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. USA, 86: 99–103.
Loven, DP, Leeper, DB and Oberley, LW, (1985) Superoxide dismutase levels in Chinese hamster ovary cells and ovarian carcinoma cells after hyperthermia or exposure to cycloheximide. Cancer Res., 45: 3029–3033.
Lunee, J, Halloran, SP, White, AG and Dormandy, TL, (1981) Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis. J. Rheumatol., 8: 233–245.
Malis, CD and Bonventre, JV, (1986) Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for postishemic and toxic mitochondrial damage. J. Biol. Chem., 261: 14201–14208.
Maridonneau-Parini, I, Clerc, J and Polla, BS, (1988) Heat shock inhibits NADPH oxidase in human neutrophils. Biochem. Biophys. Res. Commun., 154: 179–186.
Matthews, N and Neale, ML, (1987) Studies of the mode of action of tumor necrosis factor on tumor cells in vivo. Lymphokine, 14: 323–352.
Okada, Y and Hazama, A, (1989) Volume-regulatory ion channels in epithelial cells. NIPS, 4: 238–242.
Patriarca, EJ and Maresca, B, (1990) Acquired thermotolerance following heat shock protein synthesis prevents impairement of mitochondrial ATPase activity at elevated temperatures in Saccharomyces cerevisiae. Exp. Cell Res., 190: 57–64.
Polla, BS, Healy, A, Amento, EP and Krane, SM, (1986) 1,25-dihydroxyvitamin D maintains adherence of human monocytes and protects them from thermal injury. J. Clin. Invest., 77: 1332–1339.
Polla, BS and Bonventre, JV, (1987) Heat shock protects cells dependent on oxidative metabolism from inhibition of oxidative phosphoiylation. Clin. Res. 35: 555A.
Polla, BS, Healy, AM, Wojno, WC and Krane, SM, (1987) Hormone la,25-. dihydroxyvitamin D„ modulates heat shock response in monocytes. Am. J. Physiol., 252 (Cell Physiol 21): C640 - C649.
Polla, BS, Donati, YR, Kondo, M, Toehon-Danguy, HS and Bonjour, JP, (1990a) Protection from cellular oxidative injury and calcium intrusion by N-(2-mercaptoethyl)-l,3-propanediamine, WR 1065. Biochem. Pharmacol., 40: 1469–1475.
Privalle, CT and Fridovich, I, (1987) Induction of superoxide dismutase in Escherichiacolihy heat shock. Proc. Natl. Acad. Sci. USA 84: 2723–2726.
Schroeder, JJ and Cousins, RJ, (1990) Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Proc. Natl. Acad. Sci. USA 87: 3137–3141.
Stevenson, MA and Calderwood, SK, Hahn, GM, (1986) Rapid increases in inositol triphosphate and intracellular Ca++ after heat shock. Bioehem. Biophys. Res, Commun., 137: 826–833.
Welch, WJ and Mizzen, LA (1988) Characterization of the thermotolerant cell. II. Effects on intracellular distribution of heat-shock protein 70, intermediate filaments, and small nuclear ribonueleoprotein complexes. J. Cell Biol., 106: 1117–1130.
Wong, GHW, Elwell, JH, Oberley, LW and Goeddel, DV, (1989) Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell, 58: 923–931.
Young, DB, (1990) Chaperonins and the immune response. Sem. Cell Biol., 1: 27–35.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Polla, B.S., Mili, N., Kantengwa, S. (1991). Heat Shock and Oxidative Injury in Human Cells. In: Maresca, B., Lindquist, S. (eds) Heat Shock. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76679-4_30
Download citation
DOI: https://doi.org/10.1007/978-3-642-76679-4_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-76681-7
Online ISBN: 978-3-642-76679-4
eBook Packages: Springer Book Archive