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Role of Bacterial Translocation and Selective Gut Decontamination in the Development of Multiple Organ Failure

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Shock, Sepsis, and Organ Failure

Abstract

Sepsis associated with the sequential failure of multiple organ functions (MOF) presently is the most important cause of death in surgical and ICU patients. The mortality of MOF still is 60%, despite optimal treatment in the ICU and administration of a large variety of antibiotic regimens.

“We are left in the hands of the generations (of doctors) which, having heard of microbes…suddenly concluded that the whole art of healing could be summed up in the formula: Find the microbe and kill it.”.

George Bernard Shaw 1906

“… it became clear that the way clinicians used the word infection led directly to the blunt multiple trauma patient floating through his hospital course on an absolute ocean of broad spectrum antibiotics that both directly contributed to his disease and caused more important therapeutic maneuvers to be either ignored or under utilized.”.

John Border 1990

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Authors and Affiliations

  1. Department of Surgery, University Hospital St. Radboud, 6500 HB, Nijmegen, The Netherlands

    R. J. A. Goris, I. P. T. van Bebber & Th. Hendriks

Authors
  1. R. J. A. Goris
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  2. I. P. T. van Bebber
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  3. Th. Hendriks
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Editor information

Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, 1200, Wien, Austria

    Günther Schlag  & Heinz Redl  & 

  2. Maryland Institute for Emergency Medical Services Systems, Department of Surgery, Medical School, University of Maryland, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  3. School of Medicine, John Hopkins University, 22 S. Greene Street, Baltimore, MD, 21201, USA

    John H. Siegel MD

  4. Shriners Burns Institute and The University of Texas Medical Branch, 610 Texas Avenue, Galveston, Texas, 77550, USA

    Daniel L. Traber

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© 1991 Springer-Verlag Berlin, Heidelberg

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Goris, R.J.A., van Bebber, I.P.T., Hendriks, T. (1991). Role of Bacterial Translocation and Selective Gut Decontamination in the Development of Multiple Organ Failure. In: Schlag, G., Redl, H., Siegel, J.H., Traber, D.L. (eds) Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76511-7_6

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  • DOI: https://doi.org/10.1007/978-3-642-76511-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53831-8

  • Online ISBN: 978-3-642-76511-7

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