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Chemoembolisation in Regional Chemotherapy

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Drug Delivery in Cancer Treatment II

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

Metastases from primary gastrointestinal cancers to the liver contribute to the morbidity and mortality of up to 25% of all cancer patients. The prognosis of patients with liver metastases from a primary tumour in colon or rectum is poor, i.e., 70% of them will die within one year and at two years only 8–10% remain alive [1]. Surgical resection is the only current means of achieving a cure for unilobar liver colorectal metastases resulting in survival times of more than 5 years. Despite recent advances in early diagnosis and general patient care, less than 5% of all cases of colorectal cancer metastatic to liver and about 10% of all primary hepatocellular carcinomas are truly resectable for cure [1–4]. As extensive trials with systemic chemotherapy and hepatic arterial occlusion, either by ligation or by embolisation, have yielded disappointing response rates, the treatment of liver metastases still constitutes a major oncologic challenge [5,6].

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  1. Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands

    H. P. J. M. Noteborn & J. G. McVie

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  1. H. P. J. M. Noteborn
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  1. Department of Surgery, Regional Hospital, 70185, Örebro, Sweden

    Lennart Domellöf

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Noteborn, H.P.J.M., McVie, J.G. (1989). Chemoembolisation in Regional Chemotherapy. In: Domellöf, L. (eds) Drug Delivery in Cancer Treatment II. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74709-0_6

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