Abstract
Large tumor antigen (T antigen) combines several functional domains on one polypeptide chain of 708 amino acids. One domain is responsible for a specific and an unspecific interaction of T antigen with DNA (see: Fanning et al., Loeber et al., this volume) and a second domain contains an enzymatic activity that breaks the hydrogen bonds of double-stranded (ds) DNA at the expense of ATP (Stahl et al. 1986; for review, see also: Riby and Lane 1983; Stahl and Knippers 1987).
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© 1989 Springer-Verlag Berlin · Heidelberg
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Scheffner, M., Wessel, R., Stahl, H. (1989). SV40 T Antigen Catalyzed Duplex DNA Unwinding. In: Knippers, R., Levine, A.J. (eds) Transforming Proteins of DNA Tumor Viruses. Current Topics in Microbiology and Immunology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74578-2_5
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DOI: https://doi.org/10.1007/978-3-642-74578-2_5
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