Summary
Using panel 2 of a new patch test, the TRUE Test (TT), 369 consecutive patients with contact dermatitis and 37 healthy controls were patch tested with 11 different allergens (or allergen mixes). For control, the same allergens in standard concentrations in petrolatum (except Kathon CG in water) were applied using the Finn chamber (FC) technique. The allergen doses of TT were chosen according to the results of a previous serial dilution patch-test study. In the population tested, there were reactors to all the 11 allergens or allergen mixes. The concordance of positive reactions was 60% between the TT and the FC technique, 28% were indicated only with TT and 12% only with FC. The frequency of questionable and irritant reactions was about the same for the two tests and was recorded in less than 1% of all test patches. In 2 of 37 healthy volunteers tested, late reactions after 5–7 days appeared. The study indicates that TT is a well-standardized technique and gives a good accuracy.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Fischer T, Rystedt I (1985) False-positive, follicular and irritant patch test reactions to metal salts. Contact Dermatitis 12: 93–98.
Kalimo K, Lammintausta K (1984) 24 and 48 h allergen exposure in patch testing. Contact Dermatitis 10: 25–29.
Schmidt H, Schultz Larsen F, Ølholm Larsen P, Søgaard H (1980) Petechial reaction following patch testing with cobalt. Contact Dermatitis 6: 91–94.
Fischer T, Maibach HI (1984) Amount of nickel applied with a standard patch test. Contact Dermatitis 11: 285–287.
Fischer T, Maibach HI (1985) The thin layer rapid use epicutaneous test (TRUE-test), a new patch test method with high accuracy. Br J Dermatol 112: 63–68.
Lachapelle J-M, et al. (1988) European multicenter study of the TRUE Test. Contact Dermatitis 11: 91–97.
Ruhnek-Forsbeck M, et al. (1988) Comparative multi-center study with TRUE Test and Finn Chamber patch test methods in eight Swedisch hospitals. Acta Derm Venereol (Stockh) 68: 123–128.
Fischer T, Maibach HI (1989) The science of patch test standardization. Immunology and Allergy Clinics. Saunders, Philadelphia (in press).
Fregert S (1981) Manual of contact dermatitis, 2nd edn. Munksgaard, Copenhagen.
White SI, Friedmann PS, Moss C, Simpson JM (1986) The effect of altering area of application and dose per unit area on sensitization by DNCB. Br J Dermatol 115: 663–668.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Stenberg, B. et al. (1989). Swedish Multicenter Study with TRUE Test, Panel 2. In: Frosch, P., Dooms-Goossens, A., Lachapelle, JM., Rycroft, R.J.G., Scheper, R.J. (eds) Current Topics in Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74299-6_102
Download citation
DOI: https://doi.org/10.1007/978-3-642-74299-6_102
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74301-6
Online ISBN: 978-3-642-74299-6
eBook Packages: Springer Book Archive