The Sebaceous Glands

  • Chapter
Pharmacology of the Skin I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 1))

Abstract

The sebaceous glands are lipid-secreting glands found in the dermis of mammals. Most are associated with hair follicles as pilosebaceous glands found on most of the body surface:in man they are largest and most numerous on the face, forehead, scalp and front and back of the upper chest. The free sebaceous glands are not associated with hairs and occur in the transitional zones between the skin and mucous membranes. They are particularly prevalent in the anogenital and periareolar skin and the buccal mucosal membranes, where they increase in size with age. In some mammals free sebaceous glands have become highly specialised and are concerned with the secretion of pheromones, e.g. the preputial glands of rodents, the ventral glands of the gerbil, the costovertebral glands of hamsters and the large brachial glands of lemurs.

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References

  • Alves A, Thody A, Shepherd L, Shuster S (1983) Estrogen stimulates preputial lipogenesis. J Invest Dermatol 80:358

    Google Scholar 

  • Alves A, Thody A, Fisher C, Shuster S (1986) Measurement of lipogenesis in isolated pre¬putial gland cells of the rat and the effect of oestrogen. J Endocrinol 109:1–7

    Article  CAS  PubMed  Google Scholar 

  • Archibald A (1973) A study of factors influencing sebaceous gland activity in the rat. PhD Thesis, University of Newcastle upon Tyne

    Google Scholar 

  • Archibald A, Shuster S (1967) Bioassay of androgen using the rat sebaceous gland. J Endocrinol 37:22

    Google Scholar 

  • Archibald A, Shuster S (1969) The bioassay of androgens and antiandrogens using sebum secretion in the rat. Proc R Soc Med 62:887–888

    CAS  Google Scholar 

  • Bowden PE, Meddis D, Cooper MF, Thody AJ, Shuster S (1976) Effects of 5α-reduced androgens on preputial gland size and lipogenic activity. Biochem Soc Trans 4:795–797

    CAS  PubMed  Google Scholar 

  • Bruchovsky N, Wilson JD (1968) The conversion of testosterone to 5α-androstan-17β-ol-one by rat prostate in vivo and in vitro. J Biol Chem 243:5953–5960

    CAS  PubMed  Google Scholar 

  • Burton JL (1970) The physical properties of sebum in acne vulgaris. Clin Sci 39:757

    CAS  PubMed  Google Scholar 

  • Burton JL, Shuster S (1970) Effect of L-dopa on seborrhoea of parkinsonism. Lancet 11:19–20

    Article  Google Scholar 

  • Burton JL, Cunliffe WJ, Shuster S (1970) Circadian rhythm in sebum excretion. Br J Dermatol 82:497–501

    Article  CAS  PubMed  Google Scholar 

  • Burton JL, Libman LJ, Hall R, Shuster S (1971) Laevo-dopa in acne vulgaris. Lancet II:370

    Article  Google Scholar 

  • Burton JL, Cartlidge M, Shuster S (1972 a) Variation in sebum secretion during the menstrual cycle. Acta Derm Venereol (Stockh) 53:81–84

    Google Scholar 

  • Burton JL, Libman LJ, Cunliffe WJ, Wilkinson R, Hall R, Shuster S (1972 b) Sebum excretion in acromegaly. Br Med J 1:406–408

    Article  CAS  Google Scholar 

  • Burton JL, Shuster S, Cartlidge M, Libman LJ, Martell U (1973) Lactation, sebum excretion and melanocyte stimulating hormone. Nature 243:349–350

    Article  CAS  PubMed  Google Scholar 

  • Burton JL, Shuster S, Cartlidge M (1975) The sebotrophic effect of pregnancy. Acta Derm Venereol (Stockh) 55:11–13

    CAS  Google Scholar 

  • Clark D, Thody AJ, Bowers H, Shuster S (1978) Immunoreactive α-MSH in human plasma in pregnancy. Nature 274:163–164

    Article  Google Scholar 

  • Cooper MF, Thody AJ, Shuster S (1974) Hormonal regulation of cutaneous lipogenesis:effects of hypophysectomy, posterior hypophysectomy and a-melanocyte stimulating hormone treatment. Biochim Biophys Acta 360:193–204

    CAS  PubMed  Google Scholar 

  • Cooper MF, Bowden PE, Meddis D, Thody AJ, Shuster S (1975) The effect of a-MSH and various androgens on preputial gland activity. Acta Endocrinol [Suppl] 119:250

    Google Scholar 

  • Cooper MF, Hay JB, McGibbon D, Shuster S (1976 a) Androgen metabolism and sebaceous activity in clonal acne. J Invest Dermatol 66:261

    Google Scholar 

  • Cooper MF, Meddis D, Bowden PE, Thody AJ, Shuster S (1976 b) A comparison of the effects of growth hormone and a-MSH on the sebaceous gland. J Endocrinol 72:29P–30P

    Google Scholar 

  • Cooper MF, McGibbon D, Shuster S (1977) Response of sebaceous lipogenesis to testosterone in acne. J Invest Dermatol 68:255

    Google Scholar 

  • Cooper MF, McGibbon D, Wilson PD, Shuster S (1979) Androgenic control of the human sebaceous gland. J Invest Dermatol 72:267

    Google Scholar 

  • Cotterill JA, Cunliffe WJ, Williamson B, Bulusu L (1972) Age and sex variation in skin surface lipid composition and sebum excretion rate. Br J Dermatol 87:333–340

    Article  CAS  PubMed  Google Scholar 

  • Cunliffe WJ, Shuster S (1969) Pathogenesis of acne. Lancet 1:685–687

    Article  CAS  PubMed  Google Scholar 

  • Donohoe SM, Thody AJ, Shuster S (1981) Effect of α-melanocyte stimulating hormone and ovarian steroids on preputial gland function in the female rat. J Endocrinol 90:53–58

    Article  CAS  PubMed  Google Scholar 

  • Downing DT, Strauss JS, Norton LA, Pochi PE, Stewart ME (1977) The time course of lipid formation in human sebaceous glands. J Invest Dermatol 69:407–412

    Article  CAS  PubMed  Google Scholar 

  • Ebling FJ (1948) Sebaceous glands. I. The effect of sex hormones on the sebaceous glands of the female albino rat. J Endocrinol 5:297–302

    Article  CAS  PubMed  Google Scholar 

  • Ebling FJ (1961) Failure of progesterone to enlarge sebaceous glands in the female rat. Br J Dermatol 73:65–68

    Article  CAS  PubMed  Google Scholar 

  • Ebling FJ (1963) Hormonal control of sebaceous glands in experimental animals. In: Montagna W, Ellis RA, Silvers AF (eds) Advances in biology of skin, vol 4, The sebaceous glands. Pergamon, Oxford, pp 200–210

    Google Scholar 

  • Ebling FJ, Skinner J (1967) The measurement of sebum production in rats treated with testosterone and oestradiol. Br J Dermatol 79:386–393

    Article  CAS  PubMed  Google Scholar 

  • Ebling FJ, Ebling E, Skinner J (1969 a) The influence of pituitary hormones on the response of the sebaceous glands of the rat to testosterone. J Endocrinol 45:245–256

    Article  CAS  Google Scholar 

  • Ebling FJ, Ebling E, Skinner J (1969 b) The influence of the pituitary on the response of the sebaceous and preputial glands of the rat to progesterone. J Endocrinol 45:257–263

    Article  CAS  Google Scholar 

  • Ebling FJ, Ebling E, Skinner J (1970) The effects of thyrotropic hormone and of thyroxine on the response of the sebaceous glands of the rat to testosterone. J Endocrinol 48:83–90

    Article  CAS  PubMed  Google Scholar 

  • Ebling FJ, Ebling E, McCaffery V, Skinner J (1971) The response of the sebaceous glands of the hypophysectomised castrated male rat to 5α-dihydrotestosterone, androstenedione, dehydroepiandrosterone and androsterone. J Endocrinol 51:181–190

    Article  CAS  PubMed  Google Scholar 

  • Ebling FJ, Ebling E, Randall V, Skinner J (1975) The synergistic action of α-melanocyte stimulating hormone and testosterone on the sebaceous, prostate, preputial, Harderian and lachrymal glands, seminal vesicles and brown adipose tissue in the hypophysectomised castrated rat. J Endocrinol 66:407–412

    Article  CAS  PubMed  Google Scholar 

  • Ellis RA (1967) Eccrine, sebaceous, and apocrine glands. In:Zelickson AS (ed) Ultrastructure of normal and abnormal skin. Lea & Febiger, Philadelphia

    Google Scholar 

  • Ellis RA, Hendrikson RC (1963) The ultrastructure of the sebaceous glands of man. In:Montagna W, Ellis RA, Silver AF (eds) Advances in biology of skin, vol 4, The sebaceous glands. Pergamon, Oxford

    Google Scholar 

  • Flamigni CA, Collins WP, Koullapis EN, Craft I, Dewhurst C, Sommerville IF (1971) Androgen metabolism in human skin. J Clin Endocrinol Metab 32:737–743

    Article  CAS  PubMed  Google Scholar 

  • Fulton JE, Plewig G, Kligman AM (1969) Effect of chocolate on acne vulgaris. JAMA 210:2071–2074

    Article  PubMed  Google Scholar 

  • Glenn EM, Gray J (1965) Effect of various hormones on the growth and histology of the gerbil (Meriones unguiculatus) abdominal sebaceous gland pad. Endocrinology 76:1115–1123

    Article  CAS  PubMed  Google Scholar 

  • Glenn EM, Richardson SL, Bowman BJ (1959) A method of assay of anti-tumour activity using a rat mammary fibroadenoma. Endocrinology 64:379–389

    Article  CAS  PubMed  Google Scholar 

  • Gomez EC, Hsia SL (1968) In vitro metabolism of testosterone-4-14C and Δ4-androstene-3,17-dione-4-14C in human skin. Biochemistry 7:24–32

    Article  CAS  PubMed  Google Scholar 

  • Goolamali SK, Burton JL, Shuster S (1973) Sebum excretion in hypopituitarism. Br J Dermatol 89:21–24

    Article  CAS  PubMed  Google Scholar 

  • Goolamali SK, Plummer N, Burton JL, Shuster S, Thody AJ (1974) Sebum excretion and melanocyte stimulating hormone in hypoadrenalism. J Invest Dermatol 63:253–255

    Article  CAS  PubMed  Google Scholar 

  • Goolamali SK, Evered D, Shuster S (1976) Thyroid disease and sebaceous function. Br Med J 1:432–433

    Article  CAS  PubMed  Google Scholar 

  • Greene RS, Downing DT, Pochi PE, Strauss JS (1970) Anatomical variation in the amount and composition of human skin surface lipids. J Invest Dermatol 54:240–247

    Article  CAS  PubMed  Google Scholar 

  • Haskin D, Lasher N, Rothman S (1953) Some effects of ACTH, cortisone, progesterone and testosterone on sebaceous glands in the white rat. J Invest Dermatol 20:207–211

    CAS  PubMed  Google Scholar 

  • Hay JB, Meddis D, Thody AJ, Shuster S (1976) Androgen metabolism in preputial glands of hypophysectomised rats. J Endocrinol 71:96

    Google Scholar 

  • Hay JB, Cooper MF, McGibbon D, Shuster S (1977) Comparison between sebaceous lipogenesis and androgen metabolism in skin from acne patietns. J Invest Dermatol 68:253

    Google Scholar 

  • Hay JB, Meddis D, Thody AJ, Shuster S (1982) Mechanism of action of α-melanocyte stimulating hormone in rat preputial glands:the role of androgen metabolism. J Endocrinol 94:289–294

    Article  CAS  PubMed  Google Scholar 

  • Hsia SL, Voigt V (1974) Inhibition of DHT production:an effective means of blocking androgen action in the hamster sebaceous gland. J Invest Dermatol 62:224–227

    Article  CAS  PubMed  Google Scholar 

  • Ikai K (1959) Rate of sebum excretion from the glands onto the skin surface. J Invest Der-matol 32:27–33

    CAS  Google Scholar 

  • Kellum RE, Strangfleld K, Ray LF (1970) Acne vulgaris. Studies in pathogenesis:triglyceride hydrolysis by Corynebacterium acnes in vitro. Arch Dermatol 101:41–47

    Article  CAS  PubMed  Google Scholar 

  • Kirk E (1948) Quantitative determination of the skin lipid secretion in middle aged and old individuals. J Gerontol 3:251–266

    CAS  PubMed  Google Scholar 

  • Krahenbuhl C, Desaulles PA (1969) Interactions between α-MSH and sex steroids on the preputial glands of female rats. Experientia 25:1193–1195

    Article  CAS  PubMed  Google Scholar 

  • Lindholm JS, Downing DT (1980) Occurrence of squalene in skin surface lipids of the otter, the beaver and the kinkajou. Lipids 15:1062–1063

    Article  CAS  PubMed  Google Scholar 

  • Lucas PD, Donohoe SM, Thody AJ (1982) The role of estrogen and progesterone in the control of preputial gland sex attractant odors in the female rat. Physiol Behav 28:601–607

    Article  CAS  PubMed  Google Scholar 

  • Mauvais-Jarvis P, Kuttenn F, Mowszowicz I (1981) Hirsutism. Springer, Berlin Heidelberg New York

    Google Scholar 

  • McDonald I, Clarke G (1970) Variations in the levels of cholesterol and triglyceride in the skin surface fat during the menstrual cycle. Br J Dermatol 83:473–476

    Article  Google Scholar 

  • Meddis D, Thody AJ, Shuster S, Greven HM (1978) The effect of α-melanocyte stimulating hormone and various analogues on preputial gland weight in the rat. IRCS Medical Science 6:433

    CAS  Google Scholar 

  • Nakanishi S, Inone A, Kita T, Nakamura M, Chang ACY, Cohen SN, Numa S (1979) Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotrophin precursor. Nature 278:423–427

    Article  CAS  PubMed  Google Scholar 

  • Nicolaides N, Rothman S (1953) Studies on the chemical composition of human hair fat. J Invest Dermatol 21:9–14

    CAS  PubMed  Google Scholar 

  • Nicolaides N, Wells GC (1957) On the biogenesis of the free fatty acids in human skin surface fat. J Invest Dermatol 29:423–433

    CAS  PubMed  Google Scholar 

  • Nikkari T, Valavaara M (1969) The production of sebum in young rats. Effects of age, sex, hypophysectomy and treatment with somatotrophic hormone and sex hormones. J Endocrinol 43:113–118

    Article  CAS  PubMed  Google Scholar 

  • Nikkari T, Valavaara M (1970) The influence of age, sex, hypophysectomy and various hormones on the composition of the skin surface lipids of the rat. Br J Dermatol 183:459–472

    Article  Google Scholar 

  • Pietras RJ (1981) Sex pheromone production by preputial gland:the regulatory role of estrogen. Chem Sens 6:391–408

    Article  CAS  Google Scholar 

  • Plewig G, Christophers E (1974) Renewal rate of human sebaceous glands. Acta Derm Venereol (Stockh) 54:177–182

    CAS  Google Scholar 

  • Pochi PE, Strauss JS, Mescon H (1963) The role of adrenocortical steroids in the control of human sebaceous gland activity. J Invest Dermatol 41:391–399

    Article  CAS  PubMed  Google Scholar 

  • Pochi PE, Downing DT, Strauss JS (1970) Sebaceous gland response in man to prolonged total caloric deprivation. J Invest Dermatol 55:303–309

    Article  CAS  PubMed  Google Scholar 

  • Robin M, Kepecs JC (1953) The relationship between certain emotional states and the rates of secretion of sebum. J Invest Dermatol 20:373–384

    CAS  PubMed  Google Scholar 

  • Russell MJ (1976) Human olfactory communication. Nature 260:520–522

    Article  CAS  PubMed  Google Scholar 

  • Rust S, Harth P, Herrmann F (1968) Untersuchungen der freien Fettsäuren im Hautober-flächenfett von Hautgesunden. Arch Klin Exp Dermatol 231:300–310

    Article  CAS  PubMed  Google Scholar 

  • Rust S, Harth P, Herrmann F (1970) Untersuchungen der freien Fettsäuren in Hautober-flächenfett von Psoriatikern. Arch Klin Exp Dermatol 238:207–216

    Article  CAS  PubMed  Google Scholar 

  • Shuster S (1976) Hypothesis:the biological purpose of acne. Lancet 1:1328

    Article  CAS  PubMed  Google Scholar 

  • Shuster S (1982) The sebaceous glands and primary cutaneous virilism. In:Jeffcoate SL (ed) Androgens and antiandrogen therapy. Wiley, Chichester

    Google Scholar 

  • Shuster S, Thody AJ (1974) The control and measurement of sebum secretion. J Invest Dermatol 62:172–190

    Article  CAS  PubMed  Google Scholar 

  • Shuster S, Thody AJ, Goolamali SK, Burton JL, Plummer NA, Bates D (1973) Melanocyte stimulating hormone and parkinsonism. Lancet 1:463–465

    Article  CAS  PubMed  Google Scholar 

  • Shuster S, Goolamali SK, Smith AG, Thody AJ, Alvarez-Ude F, Kerr DNS (1976) Decreased sebum excretion in chronic renal failure. Br Med J 1:23–24

    Article  CAS  PubMed  Google Scholar 

  • Shuster S, Hinks WM, Thody AJ (1977) Effect of sex and age at gonadectomy on the sebaceous response to progesterone. J Endocrinol 73:67–70

    Article  CAS  PubMed  Google Scholar 

  • Silman RE, Chard T, Lowry PJ, Smith I, Young IM (1976) Human foetal pituitary peptides and parturition. Nature 260:716–718

    Article  CAS  Google Scholar 

  • Stoddart DM (1980) Aspects of the evolutionary biology of mammalian olfaction. In:Stoddart DM (ed) Olfaction in mammals. Academic, London

    Google Scholar 

  • Strauss JS, Kligman AM (1961) Effect of progesterone and progesterone like compounds on the human sebaceous glands. J Invest Dermatol 36:309–318

    CAS  Google Scholar 

  • Strauss JS, Pochi PE (1963) The hormonal control of sebaceous glands. In:Montagna W, Ellis RA, Silvers AF (eds) Advances in biology of skin, vol 4. Sebaceous glands. Pergamon, Oxford

    Google Scholar 

  • Strauss JS, Downing DT, Ebling FJ (1983) Sebaceous glands. In:Goldsmith LA (ed) Bio-chemistry and physiology of the skin, vol II. Oxford University Press, New York

    Google Scholar 

  • Thody AJ, Dijkstra H (1978) Effect of ovarian steroids on preputial gland odours in the female rat. J Endocrinol 77:397–403

    Article  CAS  PubMed  Google Scholar 

  • Thody AJ, Shuster S (1970) The effect of hypophysectomy and testosterone on the activity of the sebaceous glands of castrated rats. J Endocrinol 47:219–224

    Article  CAS  PubMed  Google Scholar 

  • Thody AJ, Shuster S (1971a) The effect of hypophysectomy on the response of the sebaceous gland to testosterone propionate. J Endocrinol 49:329–333

    Article  CAS  Google Scholar 

  • Thody A J, Shuster S (1971 b) The effect of adrenalectomy and adrenocortico trophic hormone on sebum secretion in the rat. J Endocrinol 49:325–328

    Article  CAS  Google Scholar 

  • Thody AJ, Shuster S (1971c) Sebotrophic activity of β-lipotrophin. J Endocrinol 50:533–534

    Article  CAS  Google Scholar 

  • Thody AJ, Shuster S (1971d) Increased sebum secretion in adult female rats after neonatal treatment with testosterone propionate. J Endocrinol 49:677–681

    Article  CAS  Google Scholar 

  • Thody AJ, Shuster S (1972a) A study of the relationship between the thyroid gland and sebum secretion in the rat. J Endocrinol 54:239–244

    Article  CAS  Google Scholar 

  • Thody AJ, Shuster S (1972b) The control of sebum secretion by the posterior pituitary. Nature 237:346–347

    Article  CAS  Google Scholar 

  • Thody AJ, Shuster S (1973) A possible role of MSH in the mammal. Nature 245:207–209

    Article  CAS  PubMed  Google Scholar 

  • Thody AJ, Shuster S (1975) Control of sebaceous gland function in the rat by α-melanocyte stimulating hormone. J Endocrinol 64:504–510

    Article  Google Scholar 

  • Thody AJ, Shuster S (1976) α-MSH and the metabolism of testosterone in the skin of the rat. J Invest Dermatol 66:264

    Google Scholar 

  • Thody AJ, Cooper MF, Bowden PE, Meddis D, Shuster S (1976) Effect of α-melanocyte stimulating hormone and testosterone on cutaneous and modified sebaceous glands in the rat. J Endocrinol 71:279–288

    Article  CAS  PubMed  Google Scholar 

  • Thody AJ, Meddis D, Shuster S (1978) Increased sebaceous gland activity in the adult rat after α-melanocyte stimulating hormone treatment during early life. J Invest Dermatol 70:328–330

    Article  CAS  PubMed  Google Scholar 

  • Thody AJ, Fisher C, Kendal-Taylor P, Jones MT, Price J, Abraham RR (1985) The mea-surement of immunoreactive α-melanocyte stimulating hormone in human plasma. Acta Endocrinol 110:313–318

    CAS  PubMed  Google Scholar 

  • Thomas SE, Harrington CI, Ebling FJ (1983) An investigation into the sebum excretion rate above and below the lesion in paraplegic patients. Br J Dermatol 109:696

    Google Scholar 

  • Thomas SE, Conway J, Ebling FJ, Harrington CI (1985) Measurement of sebum excretion rate and skin temperature above and below the neurological lesion in paraplegic patients. Br J Dermatol 112:569–573

    Article  CAS  PubMed  Google Scholar 

  • Toh YC (1979) Effect of neonatal administration of thyroxine on the rate of sebum production in rats. J Endocrinol 83:199–203

    Article  CAS  PubMed  Google Scholar 

  • Toh YC (1980a) Role of the gonads in the regulation of sebaceous glands in rats:comparison of the effects of castration at birth and after birth. J Endocrinol 85:261–265

    Article  CAS  Google Scholar 

  • Toh YC (1980 b) Effect of ovariectomy at birth on the regulation of sebaceous glands in rats. J Endocrinol 86:179–182

    Article  CAS  Google Scholar 

  • Toh YC (1982) Effect of streptozotocin-induced diabetes on the activity of the sebaceous glands in rats. Endokrinologie 80:56–59

    CAS  PubMed  Google Scholar 

  • Wheatley VR, Potter JER, Lew G (1979) Sebaceous gland differentiation. II. The isolation, separation and characterization of cells from mouse preputial gland. J Invest Dermatol 73:291–296

    Google Scholar 

  • Wilson JD, Walker JD (1969) The conversion of testosterone to 5α-androstan-17β-ol-3-one (dihydrotestosterone) by skin slices of man. J Clin Invest 48:371–379

    Article  CAS  PubMed  Google Scholar 

  • Wolff HG, Lorenz TH, Graham DT (1951) Stress, emotions and human sebum:their relevance to acne vulgaris. Trans Assoc Am Physicians 64:435–44

    CAS  PubMed  Google Scholar 

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Thody, A.J., Shuster, S. (1989). The Sebaceous Glands. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin I. Handbook of Experimental Pharmacology, vol 87 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73797-8_14

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