Abstract
The effect of the glucosidase inhibitor acarbose (BAY g 5421) on colonic carbohydrate fermentation was investigated in 11 healthy volunteers. Anaerobic bacteria in the ascending colon degrade malabsorbed starch mainly to short-chain fatty acids (SCFA), the bulk of which are rapidly absorbed from the bowel lumen. Only 3%–10% of SCFA produced are excreted in feces and so can be measured by gas-liquid chromatography.
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© 1988 Springer-Verlag Berlin Heidelberg
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Scheppach, W., Fabian, C., Sachs, M., Spengler, M., Kasper, H. (1988). Effect of Acarbose on Fecal Short-Chain Fatty Acid Excretion in Man. In: Creutzfeldt, W. (eds) Acarbose for the Treatment of Diabetes Mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73583-7_23
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DOI: https://doi.org/10.1007/978-3-642-73583-7_23
Publisher Name: Springer, Berlin, Heidelberg
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