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How Physiological and Pathophysiological Factors Influence the Pharmacokinetics and Analgesic Effect of Opiates in Cancer Patients

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Drug Delivery in Cancer Treatment

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

In order to apply optimal drug delivery to a cancer patient, the fundamental principles of drug kinetics and dynamics should be followed. It is also important to understand how different physiological factors can influence the pharmacokinetics of specific drugs and consequently their effects, e.g., the analgesic effect of opiates. Some basic pharmacokinetic principles will therefore be repeated first in this chapter (for a review see Rowland & Tozer [1]).

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Author information

Authors and Affiliations

  1. Department of Biopharmaceutics and Pharmacokinetics, BMC, Uppsala University, Uppsala, Sweden

    Lennart K. Paalzow

Authors
  1. Lennart K. Paalzow
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Editors and Affiliations

  1. Department of Surgery, Regional Hospital, S-701 85, Örebro, Sweden

    Lennart Domellöf (Head) (Head)

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© 1987 Springer-Verlag Berlin Heidelberg

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Paalzow, L.K. (1987). How Physiological and Pathophysiological Factors Influence the Pharmacokinetics and Analgesic Effect of Opiates in Cancer Patients. In: Domellöf, L. (eds) Drug Delivery in Cancer Treatment. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73077-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-73077-1_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73079-5

  • Online ISBN: 978-3-642-73077-1

  • eBook Packages: Springer Book Archive

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