Abstract
Nerve fiber damage elicits a response in the parent neuron and its supporting cells which is often also accompanied by an infiltration of blood-borne cells. The extent and character of this response is related to the nature, site, and severity of the injury which may vary enormously, even under controlled experimental conditions. This paper is concerned primarily with the reaction of the parent neuron to damage and the relation of functional changes in the neuron to repair and regeneration of the lost axon and to alterations in the level of neural activity.
This work was supported by the Medical Research Council of Canada
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References
Barron KD (1983) Comparative observations on the cytologic reactions of central and peripheral nerve cells to axotomy. In: Kao CC, Bunge RP, Reier RJ (eds) Spinal cord reconstruction. Raven, New York, pp 7–40
Davis LA, Gordon T, Hoffer JA, Jhamandas J, Stein RB (1978) Compound action potentials recorded from mammalian peripheral nerves following ligation or resuturing. J Physiol 285 : 543–559
Gordon T (1983) Dependence of peripheral nerves on their target organs. In: Burnstock G, Vrbová G, O’Brien R (eds) Somatic and autonomic nerve-muscle interactions. Elsevier, Amsterdam, pp 289–235
Gordon T, Stein RB (1982) Time course and extent of recovery in reinnervated motor units of cat triceps surae muscles. J Physiol 323 : 307–323
Gordon T, Hoffer JA, Jhamandas J, Stein RB (1980) Long-term effects of axotomy on neural activity during cat locomotion. J Physiol 303 : 243–263
Grafstein B, McQuarrie IG (1978) The role of the nerve cell body in axon regeneration. In: Cotman C (ed) Neuronal plasticity. Raven, New York, pp 155–195
Gutmann E (1971) Histology of degeneration and regeneration. In: Licht (ed) Electrodiagnosis and electromyography, 3rd edn. Published by the Editor, New Haven, pp 113–133
Gutmann E, Sanders FK (1943) Recovery of fibre numbers and diameters in the regeneration of peripheral nerves. J Physiol 101 : 489–518
Hoffer JA, Stein RB, Gordon T (1979) Differential atrophy of sensory and motor fibers following section of cat peripheral nerves. Brain Res 178 : 347–361
Hoffman PL, Lasek RJ (1980) Axonal transport of the cytoskeleton in regenerating motor neurons: constancy and change. Brain Res 202 : 317–333
Kelly MEM, Shapiro J, Smith PA, Gordon T (1985) Axotomy attenuates Ca2+-sensitive potassium conductance (gK) in amphibian sympathetic neurons. In: XX Canadian congress of neurol sci. (to be published)
Kernell D (1983) Functional properties of spinal motoneurons and gradation of muscle force. In: Desmedt JE (ed) Motor control mechanisms in health and disease. Raven, New York, pp 213–226
Lasek RJ, Black MM (1977) How do axons stop growing? Some clues from the metabolism of the proteins in the slow component of axonal transport. In: Roberts et al. (eds) Mechanisms, regulation and special functions of protein synthesis in the brain. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 161–169
Lieberman AR (1971) The axon reaction: a review of the principal features of perikaryal response to axon injury. Int Rev Neurobiol 14 : 49–124
Mathews MR, Nelson VH (1975) Detachment of structurally intact nerve endings from chromatolytic neurones of rat superior cervical ganglion during the depression of synaptic transmission induced by post-ganglionic axotomy. J Physiol 245 : 91–135
Mendell LM, Munson JB, Scott JG (1976) Alterations of synapses on axotomized motoneurons. J Physiol 255 : 67–79
Nathaniel EJH, Pease DC (1963a) Degenerative changes in rat dorsal roots during Wallerian degeneration. J Ultrastruct Res 9 : 511–532
Nathaniel EJH, Pease DC (1963b) Regenerative changes in rat dorsal roots following Wallerian degeneration. J Ultrastruct Res 9 : 533–549
Ochoa J, Fowler TJ, Gilliatt RW (1972) Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat 113 : 433–455
Ochs S (1982) Axoplasmic transport and its relation to nerve function. Wiley, New York
Purves D (1975) Functional and structural changes of mammalian sympathetic neurones following interruption of their axons. J Physiol 252 : 429–463
Schlaepfer WW, Hasler MB (1979) Characterization of the calcium-induced disruption of neurofilaments in rat peripheral nerve. Brain Res 168 : 299–309
Shapovalov AI, Grantyn AA (1968) Suprasegmental synaptic influences on chromatolyzed motor neurones. Biophysics 13 : 308–319
Sjostrand J (1966) Studies on glial cells in the hypoglossal nucleus of the rabbit during nerve regeneration. Act Physiol Scand 67 [Suppl] : 270
Smith PA, Shapiro J, Kelly MEM, Gordon T (1985) Effect of axotomy on Ca2+-sensitive potassium conductance (gK) in sympathetic ganglia. Can Fed Biol Soc 28 : 92
Stein RB, Gordon T, Oguztoreli MN, Lee RG (1981) Classifying sensory patterns and their effects on locomotion and tremor. Can J Physiol Pharmacol 59 : 645–655
Suarez-Gsla BA, Pelto DJ, Thompson JM, Rapoport SI (1984) Blockers of calcium permeability inhibit neurite extension and formation of neuromuscular synapses in cell culture. Dev Brain Res 14 : 263–270
Sumner BEH (1975) A quantitative analysis of the response of presynaptic boutons to post synaptic motor axotomy. Exp Neurol 46 : 605–615
Sunderland S (1978) Nerves and nerve injuries. Livingstone, Edinburgh
Sunderland S, Ray LJ (1950) Denervation changes in mammalian striated muscle. J Neurol Neurosurg Psychiatry 13 : 159–177
Tower SS (1939) The reaction of muscle to denervation. Physiol Rev 19 : 1–48
Vrbová G, Gordon T, Jones R (1978) Nerve-muscle interaction. Chapman and Hall, London
Watson WE (1972) Some quantitative observations upon the responses of neuraglial cells which follow axotomy of adjacent neurons. J Physiol 225 : 415–435
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© 1986 Springer-Verlag Berlin Heidelberg
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Gordon, T., Davis, L. (1986). Electrical Activity in Injured Peripheral Nerves. In: Nix, W.A., Vrbová, G. (eds) Electrical Stimulation and Neuromuscular Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71337-8_7
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DOI: https://doi.org/10.1007/978-3-642-71337-8_7
Publisher Name: Springer, Berlin, Heidelberg
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