Abstract
The in vitro clonogenic assay in acute myelogenous leukemia (AML) has brought the possibility to study the proliferative and differentiating capacity of the clonogenic cells as well as their in vitro sensitivity to antileukemic drugs. Although these clonogenic cells do not represent the true leukemic stem cells, their properties of colony formation and in vitro self-renewal have been considered to reflect the characteristics of the leukemic proliferation and be correlated with the outcome of the disease [8].
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Browman G, Goldberg J, Gottlieb AJ, et al. (1983) The clonogenic assay as a reproducible in vitro system to study predictive parameters of treatment outcome in acute nonlymphoblastic leukemia. Am J Hemat 15: 227–235
Crowther D, Beard MEJ, Bateman CJT, Sewell RL (1975) Factors influencing prognosis in adults with acute myelogenous leukaemia. Br J Cancer 32: 456–464
Gustaysson A, Olofsson T (1984) Prediction of response to chemotherapy in acute leukemia by in vitro drug sensitivity testing on leukemic stem cells. Cancer Res 44: 4648–4562
Keating MJ, Smith TL, Gehan EA, et al. (1980) Factors related to length of complete remission in adult acute leukemia. Cancer 45: 2017–2029
Keating MJ, Smith TL, Gehan EA, McCredie KB, Bodey GP, Freireich EJ (1982) A prognostic factor analysis for use in development of predictive models for response in adult acute leukemia. Cancer 50: 457–465
Lihou MG, Smith Pi (1983) Quantitation of chemosensitivity in acute myelocytic leukaemia. Br J Cancer 48: 559–567
Marie JP, Zittoun R, Thevenin D, Mathieu M, Viguie F (1983) In vitro culture of clono-genic leukaemic cells in acute myeloid leukaemia: growth pattern and drug sensitivity. Br J Haemat 55: 427–437
McCulloch EA, Curtis JE, Messner HA, Senn JS, Germanson TP (1982) The contribution of blast cell properties to outcome variation in acute myeloblastic leukemia ( AML ). Blood 59: 601–607
Moriyama Y, Sanada M (1983) Leukemic colony (L-CFU) formation in vitro: clinical correlations of the in vitro growth pattern of L-CFU and drug sensitivity in acute leukemia. Acta Haemat J 46: 1583–1588
Nara N, McCulloch EA (1985) The proliferation in suspension of the progenitors of the blast cells in acute myeloblastic leukemia. Blood 65: 1484–1493
Park Ch, Wiernik PH, Morrison FS, Amare M, van Sloten K, Maloney TR (1983) Clinical correlations of leukemic clonogenic cell chemosensitivity assessed by in vitro continuous exposure to drug. Cancer Res 43: 2346–2349
Passe S, Mike V, Mertelsmann R, Gee TS, Clarkson BD (1982) Acute nonlymphoblastic leukemia. Prognostic factors in adults with long-term follow up. Cancer 50: 1462–1471
Preisler H, Barcos M, Reese P, Priore RL, Pothier L (1983) Recognition of drug resistance during remission induction therapy for acute non-lymphocytic leukemia: utility of day 6 bone marrow biopsy. Leuk Res 7: 67–75
Preisler HD, Azarnia N (1984) Assessment of the drug sensitivity of acute nonlymphocytic leukaemia using the in vitro clonogenic assay. Br J Haemat 58: 633–640
Salmon SE, von Hoff DD (1981) In vitro evaluation of anticancer drugs with the human tumor stem cell assay. Semin Oncol 8: 377–385
Schwarz RS, Mackintosh FR, Halpern J, Schrier SL, Greenberg PL (1984) Multivariate analysis of factors associated with outcome of treatment for adults with acute myelogenous leukemia. Cancer 54: 1672–1681
Zittoun R, Bouchard M, Facquet-Danis J, Percie-Du-Sert M, Bousser J (1975) Prediction of the response to the chemotherapy in acute leukemia. Cancer 35: 507–513
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© 1987 Springer-Verlag Berlin Heidelberg
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Zittoun, R., Marie, J.P., Brilhante, D., Delmer, A. (1987). Prediction of Induction and Duration of Complete Remission in Acute Myelogenous Leukemia: Value of Clonogenic Cell Properties. In: Büchner, T., Schellong, G., Hiddemann, W., Urbanitz, D., Ritter, J. (eds) Acute Leukemias. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71213-5_8
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DOI: https://doi.org/10.1007/978-3-642-71213-5_8
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