Abstract
In humans light (L) LDL is catabolised faster than heavy (H) LDL, of which it is the precursor (Thompson et al., 1982). In familial hypercholesterolaemia (FH) this relationship is lost and the catabolism of L-LDL is decreased more markedly than that of H-LDL. However, the catabolic defect, especially of L-LDL, can be partly reversed by therapeutic measures which stimulate LDL receptors. This suggests that catabolism of L-LDL is normally more dependent on LDL-receptor-mediated mechanisms than is catabolism of H-LDL (Thompson et al., 1984).
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References
Spengel FA, Harders-Spengel K, Duffield R, Wood C, Myant NB, Thompson GR (1982) The effect of partial ileal bypass on receptor-mediated uptake and catabolism of low density lipoprotein in the Rhesus monkey. Res Exp Med 180: 263–270
Teng B, Thompson GR, Sniderman AD, Forte TM, Krauss RM, Kwiterovich PO (1983) Composition and distribution of low density lipoprotein fractions in hyperapobetalipoprotei-nemia, normolipidemia and familial hypercholesterolemia. Proc Natl Acad Sci USA 80: 6662–6666
Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJP, Myant NB (1981) Defects of receptor-mediated low densitiy lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo. Proc Natl Acad Sci USA 78: 2591–2595
Thompson GR, Teng B, Sniderman A (1982) Metabolic conversion of ‘light’ to ‘heavy’ low density lipoprotein (LDL) in subjects with normal and increased plasma LDL-apoB levels Circulation 66 Supp II, 158
Thompson GR, Teng B, Sniderman AD (1984) Preferential catabolism of light LDL by the receptor-mediated pathway Circulation 70 Supp II 268
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© 1986 Springer-Verlag Berlin Heidelberg
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Kano, M., Koizumi, J., Jadhav, A., Thompson, G.R. (1986). Turnover of Light and Heavy Fractions of Human LDL in Normal and WHHL Rabbits. In: Greten, H., Windler, E., Beisiegel, U. (eds) Receptor-Mediated Uptake in the Liver. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70956-2_12
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DOI: https://doi.org/10.1007/978-3-642-70956-2_12
Publisher Name: Springer, Berlin, Heidelberg
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