Abstract
Today we have had the opportunity to consider the broad array of current approaches to the dementias with especial concern for the commonest form of dementia, Alzheimer’s disease. As we look ahead to the next steps in our search for understanding, it is appropriate not only to look at where we are and where we have been, but also to take on that most dangerous of professions, that of the prophet. This discussion will focus on neurogenetic research strategies in Alzheimer’s disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Breitner JCS, Folstein M (1984) Familial nature of Alzheimer’s disease. N Engl J Med 311: 192
Buckton KE, Whalley LJ, Lee M, Christie JE (1983) Chromosomic changes in Alzheimer’s presenile dementia. J Med Genet 20: 46–51
Franke U, de Martinville B, Coussens L, Ullrich A (1983) The human gene for the β sub-unit of nerve growth factor is located on the proximal short arm of chromosome 1. Science 222: 1248–1251
Gajdusek DC (1985) Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system. N Engl J Med 312: 714–719
Heston LL, Mastri AR, Anderson VE, White J (1981) Dementia of the Alzheimer type: clinical genetics, natural history and associated conditions. Arch Gen Psychiatry 38: 1085–1090
Marotta CA, Sajdel-Sulkowska EM (1985) Factors affecting brain protein synthesis in Alzheimer’s disease. J Neurochem 44: S191
McLachlan-Crapper DR, Lewis PN, Lukiw WJ, Sima A, Bergeron C, deBoni U (1984) Chromatin structure in dementia. Ann Neurol 15: 329–334
Morrison MR, Jamison S, Ojeda S, Pardue S, Griffin WST (1984) RNA isolation from Alzheimer’s brain. Soc Neurosci Abstr 10 (2): 1062
Ojika K, Appel SH (1983) Neurotrophic factors and Alzheimer’s disease. In: Biological aspects of Alzheimer’s disease. Banbury Report 15: 285–295
Robbins JH, Otsuka F, Tarone RE, Polinsky RJ, Brumback RA, Moshell AN, Nee LE, Ganges MB, Cayeux SJ (1983) Radiosensitivity in Alzheimer’s disease and Parkinson’s disease. Lancet i, 468–469
Sajdel-Sulkowska EM, Marotta CA (1984) Alzheimer’s disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex. Science 225: 947–949
Sheu K-FR, Kim Y-T, Blass JP, Weksler ME (1985), An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer’s disease brain. Ann Neurol 17: 444–449
Terry RD (1976) Dementia: a brief and selective review. Arch Neurol 33: 1–4
White RL (1984) Human genetics. Lancet ii 1257–1262
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bick, K.L. (1986). The Dementias: A View to the Future. In: Poeck, K., Freund, HJ., Gänshirt, H. (eds) Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70007-1_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-70007-1_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70009-5
Online ISBN: 978-3-642-70007-1
eBook Packages: Springer Book Archive