Abstract
The methyl viologen herbicide paraquat, given in single subcutaneous injection of 25 mg/kg body weight (bw) to different inbred mouse lines, caused different toxicities and resulted the recognition of sensitive and resistant strains. In general higher resistance was found in mice of H-2b than in those of H-2k and H-2d haplotypes, which correlated with their cellular superoxide dismutase (SOD) level. Increased resistance and cellular SOD content could be developed by repeated sublethal dosage of paraquat in A/PH k/d recombinant mice. Paraquat tolerance seems to be regulated by the genes identical with SOD regulatory genes linked to the H-2 region and the background genes are of low significance.
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References
Graf E, Preuss FR (1969) Gadamers Lehrbuch der chemischen Toxikologie and Anleitung zur Ausmittelung der Gifte. FR. Preuss ed. Vol. I/1. p. 460. Göttingen: Vandenhoeck and Ruprecht
Németh P, Cseke I (1983) Genetic regulation of nonspecific macrophage activation. ETCS-EURES Congr. Budapest 1983
Novak R, Bosze Z, Matkovics B (1980) Gene Affecting Superoxide Dismutase Activity Linked to the Histocompatibility Complex in H-2 Congenic Mice. Science 291: 86–87
Proudfoot AT, Stewart MS, Levitt T, Widdop B (1979) Paraquat poisoning: significance of plasmaparaquat concentrations. Lancet 11: 330–332
Rabinowitch HD, Clare DA, Crapo JD, Fridovich I (1983) Positive correlation between superoxide dismutase and resistance to paraquat toxicity in the green alga Chlorella sorokiniana. Arch. Biochem. Biophys. 225: 640–648
Sata T, Takeshige K, Takayanagi R, Minakami S (1983) Lipid peroxidation by bovine heart submitochondrial particles stimulated by 1,1’-dimethyl-4,4’-bipyridylium dichloride (paraquat). Biochem. Pharmac. 32: 13–19
Schoenberger CI, Rennard SI, Bitterman PB, Fukuda Y, Ferrans VJ, Crystal RG (1984) ParaquatInduced Pulmonar Fibrosis. Am. Rev. Respir. Dis. 129: 168–173
Smith LL, Rose MS, Wyatt I (1979) Oxygen free radicals and tissue damage (CIBA Foundation Symposium 65) p. 321 Excerpta Medica, Amsterdam 1979
Wasserman B, Block ER (1978) Prevention of acute paraquat toxicity in rats by superoxide dismutase. Aviat. Space Environ. Med. 49: 805–809
Webb DB (1983) Nephrotoxicity of Paraquat in the Sheep and the Associated Reduction in Paraquat Secretion Toxicol. and Appl. Pharmacol. 68: 282–289
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© 1985 Springer-Verlag Berlin Heidelberg
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Németh, Á., Németh, P., Harsányi, L., Lang, Á. (1985). The Genetic Control of Paraquat Sensitivity of H-2 Congenic and Recombinant Mice. In: Chambers, P.L., Cholnoky, E., Chambers, C.M. (eds) Receptors and Other Targets for Toxic Substances. Archives of Toxicology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69928-3_45
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DOI: https://doi.org/10.1007/978-3-642-69928-3_45
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