Monoclonal Antibodies to Human Lymphocyte Membrane Antigens

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Lymphocyte Hybridomas

Abstract

Recent reports have shown that the original technique of Köhler et al. (1) can be successfully applied for obtaining specific antibodies against single determinants of complex antigens, through cloning of immunoglobulin secreting hybridomas (references in this volume). Here we discuss the variety of antibodies obtained with this technique after primary immunization of mice with human lymphocytes.

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References

  1. Köhler, G., Howe, S.C., Milstein, C.: Fusion between immunoglobulin secreting and non-secreting myeloma cell lines. Eur. J. Immunol. 6, 292–295 (1976).

    Article  PubMed  Google Scholar 

  2. Trucco, M., Galfre, G., De Marchi, M., Varetto, O., Carbonara, A.O.: “tb9”, A new HLA-D Specificity defined by two homozygous ty** cells. Tissue Antigens 10, 343–344 (1977).

    Article  PubMed  CAS  Google Scholar 

  3. Carbonara, A.O., Miggiano, V.C., De Marchi, M., Trucco, M., Galfre, G., Ceppellini, R.: Collaborative participation to the Sixth International Workshop. II: The LD data. Histocompatibility testing, Copenhagen: Munksgaard, 1975, p. 494.

    Google Scholar 

  4. Williams, A.F., Galfré, G., Milstein, C.: Analysis of cell surface by xenogeneic myeloma hybrid antibodies. Cell 12, 663–673 (1977).

    Article  PubMed  CAS  Google Scholar 

  5. Bernoco, B., Bernoco, M., Ceppellini, R., van Leeuwen, A., van Rood, J.J.: B cell antigens of the HLA system: a simple seroty** technique based on non-cytotoxic anti-ß2 microglobulin reagents. Tissue Antigens 8, 253–260 (1976).

    PubMed  CAS  Google Scholar 

  6. Poulik, M.D., Bernoco, M., Bernoco, D., Ceppellini, R.: Aggregation of HLA antigens on the lymphocyte surface induced by antiserum to ß2-microglobulin. Science 182, 1352–1355 (1976).

    Google Scholar 

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© 1979 Springer-Verlag Berlin Heidelberg

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Trucco, M.M., Stocker, J.W., Ceppellini, R. (1979). Monoclonal Antibodies to Human Lymphocyte Membrane Antigens. In: Melchers, F., Potter, M., Warner, N.L. (eds) Lymphocyte Hybridomas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67448-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-67448-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09670-2

  • Online ISBN: 978-3-642-67448-8

  • eBook Packages: Springer Book Archive

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