Abstract
The usefulness of isolated liver cells for the study of hepatocellular transport and metabolism is demonstrated, using 1-naphthol and 2,2′-dichlorobiphenyl as model compounds. More than 60% of both substances is rapidly taken up by the cells. Naphthol is conjugated with sulphate and with glucuronic acid. These conjugates are released from the cells. Conjugation of dichlorobiphenyl and release of the conjugates is about 25 times slower than that of naphthol.
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© 1979 Springer-Verlag
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Schwenk, M., del Pino, V.L., Remmer, H. (1979). An Experimental Model for the Study of Hepatic Transport and Metabolism of Toxic Compounds. In: Chambers, P.L., Günzel, P. (eds) Mechanism of Toxic Action on Some Target Organs. Archives of Toxicology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67265-1_33
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DOI: https://doi.org/10.1007/978-3-642-67265-1_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-09305-3
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