Abstract
Conventional methods have failed to show that rheumatoid arthritis and connective tissue diseases such as systemic lupus erythematosus and polyarteritis are caused by viruses. The reasons for still pursuing this possibility are threefold. Firstly, the clinical features of those diseases are entirely compatible with persistent virus infections; secondly, proven virus infections have not uncommonly provoked disorders closely resembling these diseases; and thirdly, many mechanisms have been discovered by which virus can persist in mammalian cells without the production of complete readily detectable virus particles.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Appleyard, G., Maber, H.B.: Plaque formation by influenza virus in the presence of trypsin. J. gen. Virol. 25, 351–357 (1974)
Denman, A.M., Pelton, B.K.: Cell separation by size. In: Methodological Developments in Biochemistry, Vol. 2: Preparative Technique. Reid, E. (ed.). London: Longman 1973, p. 185–199
Denman, A.M., Pelton, B.K.: Control mechanism in infectious mononucleosis. Clin. exp. Immunol. 18, 13–25 (1974)
Denman, A.M., Pelton, B.K., Appleford, D., Kinsley, M.: Virus infections of lympho-reticular cells and auto-immune disease. Transplant. Rev. 31, 79–115 (1976)
Denman, A.M., Rager-Zisman, B., Merigan, T.C., Tyrrell, D.A.J.: Replication or inactivation of different viruses by human lymphocyte preparations. Infect. Immunity 9, 373–376 (1974)
Feldman, M., Basten, A.: Specific collaboration between T and B lymphocytes across a cell impermeable membrane in vitro. Nature New Biology 237, 13–15 (1972)
Hersey, P., Edwards, E., Edwards, J.: Characterization of mononuclear effector cells in human blood. Clin. exp. Immunol. 23, 104–113 (1976)
Marbrook, J.: Primary immune response in cultures of spleen cells. Lancet 1976 II, 1279–1281
Miller, R.G., Phillips, R.A.: Separation of cells by velocity sedimentation. J. cell. comp. Physiol. 73, 191–202 (1969)
Platts-Mills, T.A.E., Ishizaka, K.: IgG and IgA diphtheria antitoxin responses from human tonsil lymphocytes. J. Immunol. 114, 1058–1064 (1975)
Rager-Zisman, B., Merigan, T.C.: A useful quantitative semimicromethod for viral plaque assay. Proc. Soc. exp. Biol. (N.Y.) 142, 1174–1179 (1973)
Virelizier, J.L.: Mechanisms of immunodepression induced by viruses: possible role of infected macrophages. Biomedicine 22, 255–261 (1975)
Wheelock, E.F., Toy, S.T.: Participation of lymphocytes in viral infections. Advanc. Immunol. 16, 123–184 (1974)
Zisman, B., Denman, A.M.: Inactivation of myxoviruses by lymphoid cells. J. gen. Virol. 20, 211–233 (1973)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1977 Springer-Verlag
About this paper
Cite this paper
Denman, A.M., Appleford, D.J., Imrie, R.C., Kinsley, M.J., Pelton, B.K., Schnitzer, T. (1977). Viral Replication in Lymphocytes and the Pathogenesis of Connective Tissue Diseases. In: Glynn, L.E., Schlumberger, H.D. (eds) Experimental Models of Chronic Inflammatory Diseases. Bayer-Symposium, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66573-8_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-66573-8_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66575-2
Online ISBN: 978-3-642-66573-8
eBook Packages: Springer Book Archive