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Characterization of Biomaterials for Tissue Repair

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Biological Matrices and Tissue Reconstruction

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Abstract

Even in 1909 Bergel [3] recognized the value of fibrin as a scaffold structure for tissue regeneration. At about the same time Grey [25] and Harvey [26] described independently from one another the use of fibrin tampons to accelerate local hemostasis. Harvey studied the resorption of fibrin and discovered that xenogenous fibrin produces a foreign body reaction [26]. During the Second World War Cohn and colleagues [11] developed plasma fractionation through ethanol in the U.S.A. Seegers [47] isolated prothrombin and formed thrombin from it. These work groups were forerunners for the broad application of clotting factors in medicine. In 1943 Michael and Abbott [37] used the plasma derivatives fibrinogen and thrombin in plastic and neurosurgery. Cronkite et al. [12] used resorbable wound dressings on a basis of oxidised cellulose together with human fibrinogen and human thrombin for local hemostasis on soldiers during the Second World War. The renaissance of fibrin gluing is based on fundamental work done by Matras et al. [36] in joining severed nerves using fibrin, as well as by Spängler [48] in applying fibrinogen and thrombin for topical hemostasis.

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References

  1. Altmeppen J, Stemberger A, Ullrich H, Bonnländer G, Hansen E (1996) Autologes Thrombozyten - Gel. Hämatologie. München, Sympomed 5:15–19.

    Google Scholar 

  2. Bänninger H, Hardegger T, Tobler A, Barth A, Schüpbach P, Reinhart W, Lämmie B, Furlan M (1993) Fibrin glue in surgery: frequent development of inhibitors of bovine thrombin and human factor V. Br J of Haematol 85:528–532.

    Article  Google Scholar 

  3. Bergel S (1909) Über die Wirkung des Fibrins. Dtsch Med Wschr 35:663–665.

    Article  CAS  Google Scholar 

  4. Berguer R, Staerekel RL, Moore EE, Moore FA, Galloway WB, Mockus MB (1991) Warning: Fatal Reaction to the Use of Fibrin Glue in Deep Hepatic Wounds. Case Reports. Trauma 31(3):408–411.

    CAS  Google Scholar 

  5. Berruyer M, Amiral J, French P, Belleville J, Bastien O, Clerc J, Kassir A, Estanove S, Dechavanne M (1993) Immunization by bovine thrombin used with fibrin glue during cardiovascular operations. J Thorac Cardiovasc Surg 105:892–897.

    PubMed  CAS  Google Scholar 

  6. Blanchy BG, Coulet PR, Gautheron DC (1986) Immobilization of factor XIII on collagen membranes. J Biomed Mat Res 20:469–479.

    Article  CAS  Google Scholar 

  7. Bormann R, Reichelt H (1986) Entwicklung und funktionelle Erprobung eines autologen Fibrinklebers. Z Militärmed Berlin 27:98–101.

    CAS  Google Scholar 

  8. Brändstedt S, Frank F, Olson PS (1980) The fibrin netformed in a wound appears to act as a scaffold for migrating fibroblasts. Eur Surg Res 12:18–21.

    Google Scholar 

  9. Bull BS, Bull MH, Cardiopulmonary Bypass and the Salvaged Blood Syndrome. In: R. Pifarre: Anticoagulation, Hemostasis and Blood Preservation in Cardiovascular Surgery. Hanley & Belfus Inc., Philadelphia: 85–93.

    Google Scholar 

  10. Carroll JF, Moskowitz KA, Edwards NM, Hickey TJ, Rose EA, Budzynski AZ (1996) Immunological Assessment of patients Treated with Bovine Fibrin as a Hemostatic Agent. Thromb Heamost 76:925–931.

    CAS  Google Scholar 

  11. Cohn EJ, Strong LE, Hughes WL, Mulford DJ, Asworth JN, Melin M, Talor HL (1946) Preparation and properties of serum and plasma proteins. IV. System for these paration and fractions of the protein and lipoprotein components of biological tissues and fluids. J Am Chem Soc 68:459–475.

    CAS  Google Scholar 

  12. Cronkite EP, Deaver JM, Lonzer EL (1944) Experiences with the use of thrombin with and without soluble cellulose for local hemostasis. War Med 5:80–82.

    Google Scholar 

  13. DeDecker W (1968) Ist der fibrinöse Bindehautverschluß mit Rinderthrombin immunologisch bedenklich? Klin Monatsbl Augenheilkd 153:79–90.

    CAS  Google Scholar 

  14. Deutsch E, Frischauf H, Czembirek H, Eibl H, Marrum I, Antoni F (1971) Investigations on the Possibility of Sterilisation of Plasma Protein Preparations (Fibrinogen and AHG). Bibl. haemat., No. 38, part II, pp. 491–497 (Karger, Basel 1971) (Proc. 12th Congr int Soc Blood Transf, Moscow 1969).

    Google Scholar 

  15. Diez-Martin J, Sikkink R, Gilchrist G, Bowie W, Fass D (1990) Development of Anti-Bovine Thrombin Antibodies Following Neurosurgical Procedures Brit J Haematol Vol 74:369–370.

    CAS  Google Scholar 

  16. Dresdale A, Rose EA, Jeevanandam V (1985) Preparation of fibrin glue from single donor fresh frozen plasma.Surgery 97:750–755.

    Google Scholar 

  17. Enzmann H (1982) Sensibilisierung bei der Verwendung von Fibrinkleber. Laryngol Rhinol Otol 61(6):302–303.

    Article  CAS  Google Scholar 

  18. Ferrari M, Zia S, Valoues M, (1987) A new Technique for Hemodilution, Preoperation of Autologus Platelet Rich Plasma and intraoperative Salvage in Cardiac Surgery. Int Artif Organs 120:47.

    Google Scholar 

  19. Flaherty MJ, Henderson R, Wener MH (1989) Iatrogenic Immunization with Bovine Thrombin: A Mechanism for Prolonged Thrombin Times after Surgery. Ann Inter Med 111:631–634.

    CAS  Google Scholar 

  20. Folk JE (1980) Transglutaminases. Ann Rev Biochem 49:517–531.

    Article  PubMed  CAS  Google Scholar 

  21. Furthmayr H, Timpl R (1971) Characterization of collagen peptides by sodiumdodecyl-sulfate-polyacrylamide electrophoresis. Anal Bioch 41:510–516.

    Article  CAS  Google Scholar 

  22. Gareis-Helferich E (1968) Bindehautverschluß durch Verklebung. Klin Monatsbl Augen-heilkd 153:74–78.

    CAS  Google Scholar 

  23. Giordano GF, Giordano GF jr., Rivers SC, Chung GKT, Mamana RB, Marco JD, Raczkowski AR, Saabag A, Sandersson RG, Strug BS (1992) Determination of Homologous-Blood Usage Utilizing Autologous Platelet Rich Plasma in Cardiac Operation. Ann Thorac Surg 47:879.

    Google Scholar 

  24. Grabosch A, Bogusch G, Plockmeier K, Öllinger R (1994) In vivo studies of fibrin sealant ultrastructure. In: Schlag G., H. Redl: Wound Healing, Sealing in Surgical and Non-Surgical Fields Vol. 1. Springer Verlag Heidelberg 67–74.

    Google Scholar 

  25. Grey EC (1915) Fibrin as ahemostatic in cerebral surgery. Surg Gynec Obstet 21:452–454.

    Google Scholar 

  26. Harvey SC (1916) The use of fibrin paper and forms insurgery. Boston Med Surg J 174:658–659.

    Article  Google Scholar 

  27. Henrich A, Bäumler F, Oberschelp J, Kilian K (1988) Einfluß von drei verschiedenen Gewebeklebern auf Vollhauttransplantate bei Verbrennungen. Medwelt 39:701–706.

    Google Scholar 

  28. Henrich HA, Stitz B, Conrad F (1995) Effect of fibrin sealants on growth and adhesion of human endothelial cells. In: Schlag G., E. Wolner, F. Eckersberger: Fibrin Sealing in Surgical and Nonsurgical Fields. No. 6 Springer Verlag Heidelberg 80–87.

    Google Scholar 

  29. Israels S, Israels E (1994) Development of Antibodies to Bovine and Human Factor V in Two Children After Exposure to topical Bovine Thrombin. Am J Pediatr Hematol/ Oncol 16(3):249–254.

    Article  CAS  Google Scholar 

  30. Kaeser A, Dum N. Grundlagen der Fibrinklebung: Qualitätsanforderungen und Infektionssicherheit von Fibrinkleber. In: A Haverich, Ch Huth: Fibrinklebung in der Herz-, Gefäß-, Thoraxchirurgie. Steinkopff Darmstadt 13–24.

    Google Scholar 

  31. Knöbel P, Tribl B, Lechner K (1996) Erworbene Faktor V Inhibitoren. Hämostaseologie 16:180–7.

    Google Scholar 

  32. Kühn K (1982) Chemicalproperties of collagen. In: Furthmayr H (ed): Immunochemistry of theExtracellular Matrix, Vol I, CRC Press, Boca-Raton/Florida: 2–22.

    Google Scholar 

  33. Lambrecht JTH, Klinger M (1988) Resorption von Fibrinkleber durch isolierte Knochenzellen in der Kultur Medwelt 39:493–496.

    Google Scholar 

  34. Lawson JH, Pennell BJ, Olson JD, Mann KG (1990) Isolation and Characterization of an Acquired Antithrombin Antibody. Blood 76 (11):2249–2257.

    PubMed  CAS  Google Scholar 

  35. Lorand L (1983) New approachesto old problems in the clotting of fibrinogen. In: Mosseson W, Doolittle RF (eds) (1983) Molecular Biology of Fibrinogen and Fibrin. Ann NY Acad SciVol 408:226–233.

    Article  CAS  Google Scholar 

  36. Matras H, Dinges HP, Lassmann H, Mamoli B (1972) Zur nahtlosen interfaszikulären-Nerventransplantation im Tierexperiment. Wien Med Wschr 122:517–522.

    PubMed  CAS  Google Scholar 

  37. Michael G, Abbott W (1943) Theuse of human fibrinogen in reconstructive surgery. JAMA 123:279.

    Article  Google Scholar 

  38. Mosseson MW, Doolittle RF (1983) Molecular biology of fibrinogen and fibrin. Ann NY Acad Sci 408.

    Google Scholar 

  39. Muntean W, Zenz W, Finding K (1992) Erworbener Thrombininhibitor bei einem 9jährigen Kind nachTotalkorrektur eines univentrikulären Herzens mit Pulmonalatresie und Applikation von Fibrinkleber. Wien Klin Wochenschr 104 (4):101–104.

    PubMed  CAS  Google Scholar 

  40. Ockenfels HM, Seemann U, Goos M (1995) Allergy to fibrin tissue in dental medicine. Contact Dermatitis 32:363–364.

    Article  PubMed  CAS  Google Scholar 

  41. Ortel TL, Charles LA, Keller FG, Marcom K, Oldham HN, Kane WH, Macik BG (1994) Topical Thrombin and Aquired Coagulation Factor Inhibitors: Clinical Spectrum and Laboratory Diagnosis. Am J Hematol 45:128–135.

    Article  PubMed  CAS  Google Scholar 

  42. Oz MC, Jeevandan V, Smith CR, Williams MR, Kavnar AM, Frank RA, Mosca R, Reis RF, Rose ER (1992) Autologous Fibrin Glue from Intraoperatively Collected Platelet-Rich-Plasma. Ann Thorac Surg 53:530–531.

    Article  PubMed  CAS  Google Scholar 

  43. Quigley RL, Perkins JA, Gottner RJ, Curran RD, Kuehn BE, Hoff WJ, Wallock ME, Arentzen CE, Alexander JC Jr (1993) Intraoperative Procurement of Autologous Fibrin Glue. Ann Thorac Surg 56:387–9.

    Article  PubMed  CAS  Google Scholar 

  44. Redl H, Schlag G (1986) Properties of Different Tissue Sealants with Special Emphasis on Fibrinogen-Based Preparations. In: Fibrin Sealant in Operative Medicine. Otorhinolaryngology Vol 1. Springer Verlag, Heidelberg: 27–38.

    Google Scholar 

  45. Redl H, Schlag G, Dinges HP (1985) Vergleich zweier Fibrinkleber. Medwelt 36:769–776.

    CAS  Google Scholar 

  46. Rosolski T, Altmeppen J (1996) Neue Möglichkeiten zur Einsparung homologer Blutprodukte. Kardiotechnik 3:69–71.

    Google Scholar 

  47. Seegers WH, Brinkhous KM, Smith HP, Warner ED (1938) The purification of thrombin. J Biol Chem 126:91–95.

    CAS  Google Scholar 

  48. Spängler HP (1976) Gewebeklebung und lokale Blutstillung mit Fibrinogen, Thrombin und Blutgerinnungsfaktor XIII. Wien Klin Wschr 88, Suppl 49:1–18.

    Google Scholar 

  49. Spero JA, (1993) Bovine thrombin induced inhibitor of factor V and bleeding risk in postoperative neurosurgical patients. J Neurosurg 78:817–820.

    Article  PubMed  CAS  Google Scholar 

  50. Stemberger A, Ascherl R, Blümel G (1990) Kollagen, ein Biomaterial in der Medizin. Hämostaseologie 10:164–76.

    CAS  Google Scholar 

  51. Stemberger A, Ascherl R, Scherer MA, Kaufer CH, Pfefferer M, Blümel G (1992) Hämostyptika in der Chirurgie - in vitro Untersuchungen zur Stimulierung der Blutgerinnung sowie Festigkeit in Kombination mit der Fibrinklebung. Fibrinklebung in der Allgemein- und Unfallchirurgie, Orthopädie, Kinder- und Thoraxchirurgie. Ch. Gebhardt (Hrsg): 27–36.

    Chapter  Google Scholar 

  52. Tawes RL, Sydorak GR, Duvall TB (1994) Autologous fibrin glue: the last step in operative hemostasis. Am J Surg 168 (2):120–122.

    Article  PubMed  Google Scholar 

  53. Wynne TG, Laszlo GP (1946) Thrombin technique in ophthalmic surgery. Br J Ophthalmol 30:176–178.

    Article  Google Scholar 

  54. Zeichhardt H, Scheiermann N, Spicher G, Deinhardt F (1987) Stabilität und Inaktivierung des Human Immunodeficiency Virus (HIV). Dt Ärztebl 84 (18):874–879.

    Google Scholar 

  55. Zehnder JL, Leung LK (1990) Development of Antibodies to Thrombin and Factor V with Recurrent Bleeding in a Patient to Topical Bovine Thrombin. Blood (76):2011–2016.

    PubMed  CAS  Google Scholar 

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Authors
  1. Axel Stemberger
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  2. Jürgen Altmeppen
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  3. Frank Bader
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  4. Andreas Calatzis
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  1. Abt. Plastische und Handchirurgie, Chirurgische Universitätsklinik Freiburg, Hugstetter Straße 55, D-79106, Freiburg, Germany

    G. Björn Stark , Raymund Horch  & Eszter TÁczos ,  & 

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Stemberger, A., Altmeppen, J., Bader, F., Calatzis, A. (1998). Characterization of Biomaterials for Tissue Repair. In: Stark, G.B., Horch, R., TÁczos, E. (eds) Biological Matrices and Tissue Reconstruction. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60309-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-60309-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64347-7

  • Online ISBN: 978-3-642-60309-9

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