Abstract
In order to elucidate the relations between structure and membrane modifying properties of alamethicin-type antibiotics investigations with natural, modified natural and synthetic analogues have been carried out. The activity pattern splits up into three modes: 1. activity in form of resolvable, stable (τ > 1 ms) pores, 2. activity in form of voltage-dependent burst formation (not resolvable fluctuations) which finally leads to membrane lysis, 3. inactive behaviour. Whereas modes 2. and 3. are to differentiate by hemolysis and artificial lipid bilayer measurements, single pore events (mode 1) are only observable with the bilayer system.
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© 1979 Springer-Verlag Berlin Heidelberg
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Brückner, H., Jung, G., Hanke, W., Boheim, G. (1979). Structural Requirements for Membrane Modifying Activity in Alamethicin-Type Antibiotics. In: Adam, G., Stark, G. (eds) Annual Meeting of the Deutsche Gesellschaft für Biophysik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51881-2_53
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DOI: https://doi.org/10.1007/978-3-642-51881-2_53
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-09684-9
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