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Cholinomimetic Drugs and Release of the Adrenergic Transmitter

  • Conference paper
New Aspects of Storage and Release Mechanisms of Catecholamines

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 2))

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Abstract

In this paper an attempt will be made to describe the actions of cholinomimetic drugs on the peripheral adrenergic nerve fibres as far as its capacity to retain, or to release, the transmitter is concerned. The conventional classification of cholinomimetic responses in nicotinic and muscarinic ones will be adhered to. As to be shown by the results, the classification can also be extended to describe the responses of the peripheral adrenergic nerve fibre to acetylcholine, nicotine, methacholine, and to several of their congeners. Hexamethonium was used to antagonize the activation of nicotine receptors (in the following the more frequently applied term “nicotinic” will be used); atropine, under more careful control of dose-response relationships, was employed to antagonize activation of muscarine (in the following “muscarinic”) receptors.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität, Langenbeckstraße 1, Mainz, D-6500, Deutschland

    Prof. Dr. E. Muscholl

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  1. Prof. Dr. E. Muscholl
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Editors and Affiliations

  1. Klinikum Essen der Ruhruniversität Bochum, Essen-Holsterhausen, 4300, Deutschland

    Hans-Joachim Schümann (Direktor des Pharmakologischen Institutes) (Direktor des Pharmakologischen Institutes)

  2. Farbenfabriken Bayer AG., Wuppertal-Elberfeld, 5600, Deutschland

    Günter Kroneberg (Vorstand des Institutes für Pharmakologie) (Vorstand des Institutes für Pharmakologie)

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Muscholl, E. (1970). Cholinomimetic Drugs and Release of the Adrenergic Transmitter. In: Schümann, HJ., Kroneberg, G. (eds) New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer-Symposium, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46241-2_16

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  • DOI: https://doi.org/10.1007/978-3-642-46241-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46243-6

  • Online ISBN: 978-3-642-46241-2

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