Effect of Some Metabolic Factors and Drugs on Uptake and Release of Catecholamines in vitro and in vivo

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New Aspects of Storage and Release Mechanisms of Catecholamines

Part of the book series: Bayer-Symposium ((BAYER-SYMP,volume 2))

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Abstract

Since the demonstration of ATP in relatively large amounts in adrenal medullary granules (Hillarp, Högberg and Nilson, 1955) and in nerve granules (Schümann, 1958) this nucleotide has been implicated in the amine storage function of these organelles.

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References

  • Armett, C. J., Ritchie, J. M.: The action of acetylcholine on conduction in mammalian nonmyelinated fibres and its prevention by an anticholinesterase. J. Physiol. (Lond.) 152, 141–158 (1960).

    CAS  Google Scholar 

  • Axelrod, J., Hertting, G., Potter, L.: Effect of drugs on the uptake and release of 3H-norepinephrine in the rat heart. Nature (Lond.) 194, 297 (1962).

    Article  CAS  Google Scholar 

  • Bell, C.: Fine structural localization of acetylcholinesterase at a cholinergic vasodilator nervearterial smooth muscle synapse. Circulat. Res. 24, 61–70 (1969).

    PubMed  CAS  Google Scholar 

  • Belleau, B.: Relationships between agonists, antagonists and receptor sites. Ciba Foundation Symposium “Adrenergic Mechanisms”, p. 223–245. London: J. & A. Churchill Ltd. 1960.

    Google Scholar 

  • —, Martel, R., Lacasse, G., Menard, M., Weinberg, N. L., Perron, Y. G.: N-Carboxylic acid esters of 1,2- and 1,4-dihydroquinolines. A new class of irreversible inactivators of the catecholamine α receptors and potent central nervous system depressants. J. Amer. Chem. Soc. 90, 823 (1968).

    Article  CAS  Google Scholar 

  • Birmingham, A. T., Wilson, A. B.: Preganglionic and postganglionic stimulation of the guinea-pig isolated vas deferens preparation. Brit. J. Pharmacol. 21, 569–580 (1963).

    PubMed  CAS  Google Scholar 

  • Burgen, A. S. V., Iversen, L. L.: The inhibition of noradrenaline uptake by sympathomimetic amines in the rat isolated heart. Brit. J. Pharmacol. 25, 34–49 (1965).

    PubMed  CAS  Google Scholar 

  • Burger, A., Philippu, A., Schümann, H. J.: Untersuchungen zur Bedeutung einer ATPase aus Milznervengranula. Naunyn Schmiedebergs Arch. Pharmak. exp. Path. 260, 101–102 (1968).

    Article  CAS  Google Scholar 

  • Burn, J. H.: Introductory remarks. In: Adrenergic transmission, Sec. V. Pharmacol. Rev. 18, 459–470 (1966).

    CAS  Google Scholar 

  • —, Rand, M. J.: The action of sympathomimetic amines in animals treated with reserpine. J. Physiol. (Lond.) 144, 314–336 (1958).

    CAS  Google Scholar 

  • — — Sympathetic postganglionic mechanism. Nature (Lond.) 184, 163–165 (1959).

    Article  Google Scholar 

  • Burnstock, G., Holman, M. E.: Smooth muscle: Autonomic nerve transmission. Ann. Rev. Physiol. 25, 61–85 (1963).

    Article  CAS  Google Scholar 

  • —, Robinson, P. M.: Localization of catecholamines and acetylcholinesterase in autonomic nerves. Circulat. Res. 21, Suppl. III, 43–55 (1967).

    CAS  Google Scholar 

  • Bygdeman, S., Johnsen, Ø.: Studies on the effect of adrenergic blocking drugs on catecholamine-induced platelet aggregation and uptake of noradrenaline and 5-hydroxytryptamine. Acta physiol. scand. 75, 129–138 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Carlsson, A., Hillarp, N.-Å., Waldeck, B.: A Mg++-ATP dependent storage mechanism in the amine granules of the adrenal medulla. Med. exp. 6, 47–53 (1962).

    PubMed  CAS  Google Scholar 

  • Carlsson, A., Hillarp, N.-Å., Waldeck, B.: Analysis of the Mg++-ATP dependent storage mechanism in the amine granules of the adrenal medulla. Acta physiol. scand. 59, Suppl. 215 (1963).

    Google Scholar 

  • Davies, B. N., Horton, E. W., Withrington, P. G.: The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation. J. Physiol. (Lond.) 188, 38P–39P (1967).

    CAS  Google Scholar 

  • Day, M. D., Owen, D. A. A.: The interaction between angiotensin and sympathetic vasoconstriction in the isolated artery of the rabbit ear. Brit. J. Pharmacol. 34, 499–507 (1968).

    CAS  Google Scholar 

  • D’iorio, A.: The release of catecholamines from the isolated chromaffine granules of the adrenal medulla using sulphydryl inhibitors. Canad. J. Biochem. 35, 395–400 (1957).

    Article  PubMed  Google Scholar 

  • v. Euler, U. S.: Sympathin, histamine and acetylcholine in mammalian nerves. J. Physiol. (Lond.) 107, 10P–11P (1948).

    Google Scholar 

  • — Acute neuromuscular transmission failure in vas deferens after reserpine. Acta physiol. scand. 76, 255–256 (1969).

    Article  Google Scholar 

  • —, Hedqvist, P.: Inhibitory action of prostaglandins E1 and E2 on the neuromuscular transmission in the guinea pig vas deferens. Acta physiol. scand. 77, 510–512 (1969).

    Article  Google Scholar 

  • —, Lishajko, F.: Effect of reserpine on the release of noradrenaline from transmitter granules in adrenergic nerves. Science 132, 351–352 (1960).

    Article  Google Scholar 

  • — — Effect of reserpine on the release of catecholamines from isolated nerve and chromaffin cell granules. Acta physiol. scand. 52, 137–145 (1961).

    Article  CAS  Google Scholar 

  • — — (1) Effect of adenine nucleotides on catecholamine release and uptake in isolated adrenergic nerve granules. Acta physiol. scand. 59, 454–461 (1963).

    Article  CAS  Google Scholar 

  • — — (2) Effect of reserpine on the uptake of catecholamines in isolated nerve storage granules. Int. J. Neuropharmacol. 2, 127–134 (1963).

    Article  Google Scholar 

  • — — Effect of drugs on the storage granules of adrenergic nerves. In: Pharmacology of cholinergic and adrenergic transmission, Proc. 2nd Internat. Pharmacol. Meeting, Prague, 1963, pp. 245–259, Praha: Czechoslovak Medical Press 1965.

    Google Scholar 

  • — — (1) Effect of directly and indirectly acting sympathomimetic amines on adrenergic transmitter granules. Acta physiol. scand. 73, 78–92 (1968).

    Article  Google Scholar 

  • — — (2) Inhibitory action of adrenergic blocking agents on reuptake and net uptake of noradrenaline in nerve granules. Acta physiol. scand. 74, 501–506 (1968).

    Article  Google Scholar 

  • — — (3) Observations on the actions of prenylamine (Segontin) in vivo and on adrenergic transmitter granules. Biochim. appl. (Parma) 14, Suppl. I, 17–32 (1968).

    Google Scholar 

  • — — Effects of some metabolic co-factors and inhibitors on transmitter release and uptake in isolated adrenergic nerve granules. Acta physiol. scand. 77, 298–307 (1969).

    Article  Google Scholar 

  • —, Persson. N.-Å.: Potentiation of adrenergic cardiovascular effects of two quaternary nicotine analogues by reserpine. Acta physiol. scand. 78, 459–464 (1970).

    Article  Google Scholar 

  • Ferry, C. B.: The sympathomimetic effect of acetylcholine on the spleen of the cat. J. Physiol. (Lond.) 167, 487–504 (1963).

    CAS  Google Scholar 

  • Folkow, B., Häggendal, J., Lisander, B.: Extent of release and elimination of noradrenaline at peripheral adrenergic nerve terminals. Acta physiol. scand. 72, Suppl. 307 (1968).

    Google Scholar 

  • Hedqvist, P.: (1) On the mechanism of depletion of noradrenaline stores by iso-monomethyl- nicotinium bromide. Acta physiol. scand. 78, 117–122 (1970).

    Article  PubMed  CAS  Google Scholar 

  • — (2) Modulating effect of prostaglandin E2 on noradrenaline release from the isolated cat spleen. Acta physiol. scand. 75, 511–512 (1969).

    Article  PubMed  CAS  Google Scholar 

  • — (3) Antagonism between prostaglandin E2 and phenoxybenzamine on noradrenaline release from the cat spleen. Acta physiol. scand. 76, 383–384 (1969).

    Article  PubMed  CAS  Google Scholar 

  • —, Brundin, J.: Inhibition of prostaglandin E1 of noradrenaline release and of effector response to nerve stimulation in the cat spleen. Life Sci. 8, 389–395 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Hillarp, N.-Å.: Enzymic systems involving adenosinephosphates in the adrenaline and noradrenaline containing granules of the adrenal medulla. Acta physiol. scand. 42, 144–165 (1958).

    Article  PubMed  CAS  Google Scholar 

  • — Some problems concerning the storage of catechol amines in the adrenal medulla. Ciba Foundation Symposium “Adrenergic Mechanisms”, p. 481–501. London: J. & A. Churchill Ltd. 1960.

    Google Scholar 

  • —, Högberg, B., Nilson, B.: Adenosine triphosphate in the adrenal medulla of the cow. Nature (Lond.) 176, 1032–1033 (1955).

    Article  CAS  Google Scholar 

  • Hukovic, S.: Responses of the isolated sympathetic nerve ductus deferens preparation of the guinea-pig. Brit. J. Pharmacol. 16, 188–194 (1961).

    PubMed  CAS  Google Scholar 

  • Iversen, L. L.: The uptake of noradrenaline by the isolated perfused rat heart. Brit. J. Pharmacol. 21, 523–537 (1963).

    PubMed  CAS  Google Scholar 

  • Jonasson, J., Rosengren, E., Waldeck, B.: Effects of some pharmacologically active amines on the uptake of arylalkylamines by adrenal medullary granules. Acta physiol. scand. 60, 136–140 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Katz, B.: The release of neural transmitter substances. The Sherrington Lectures X. Liverpool: Univ. Press 1969.

    Google Scholar 

  • Kirshner, N.: Uptake of catecholamines by a particulate fraction of the adrenal medulla. J. biol. Chem. 237, 2311–2317 (1962).

    PubMed  CAS  Google Scholar 

  • Lindmar, R., Löffelholz, K., Muscholl, E.: A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents. Brit. J. Pharmacol. 82, 280–294 (1968).

    Google Scholar 

  • —, Muscholl, E:: Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsflüssigkeit und die Noradrenalinaufnahme in das isolierte Herz. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 247, 469–492 (1964).

    Article  CAS  Google Scholar 

  • Lishajko, F.: Release, reuptake and net uptake of dopamine, noradrenaline and adrenaline in isolated sheep adrenal medullary granules. Acta physiol. scand. 76, 159–171 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Malik, K. U., Ling, G. M.: Modification by acetylcholine of the response of rat mesenteric arteries to sympathetic stimulation. Circulat. Res. 25, 1–9 (1969).

    PubMed  CAS  Google Scholar 

  • Mantegazza, P., Naimzada, M. K.: Attivita della prostaglandina E1 sul preparato nervo ipogastrico-deferente di varie specie animali. Atti Accad. med. lombarda 20, 58–64 (1965).

    CAS  Google Scholar 

  • Nachmansohn, D.: Role of acetylcholine in neuromuscular transmission. Ann. N. Y. Acad. Sci. 135, 136–149 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Nasmyth, P. A.: An investigation of the action of tyramine and its interrelationship with the effects of other sympathomimetic amines. Brit. J. Pharmacol. 18, 65–75 (1962).

    PubMed  CAS  Google Scholar 

  • Owman, Ch., Sjöstrand, N. O.: On short adrenergic neurons in the accessory male genital organs of the bull. Experientia (Basel) 22, 759–761 (1966).

    Article  Google Scholar 

  • Pfenninger, K., Sandri, C., Akert, K., Eugster, C. H.: Contribution to the problem of structural organization of the presynaptic area. Brain Res. 12, 10–18 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Schümann, H. J.: Über den Noradrenalin- und ATP-Gehalt sympathischer Nerven. Naunyn- Schmiedebergs Arch. exp. Path. Pharmak. 233, 296–300 (1958).

    Google Scholar 

  • —, Philippu, A.: The mechanism of catecholamine release by tyramine. Int. J. Neuropharmacol. 1, 179–182 (1962).

    Article  Google Scholar 

  • Sjöstrand, N. O.: Effect of some smooth muscle stimulants on the motor response of the isolated guinea pig vas deferens to hypogastric nerve stimulation. Nature (Lond.) 192, 1190–1191 (1961).

    Article  Google Scholar 

  • Smith, A. D.: Biochemistry of adrenal chromaffin granules. In: The interaction of drugs and subcellular components in animal cells, (Campbell, P. N., Ed.) London: J. A. Churchill Ltd. 1968.

    Google Scholar 

  • Stjärne, L.: Studies of catecholamine uptake storage and release mechanisms. Acta physiol. scand. 62, Suppl. 228 (1964).

    Google Scholar 

  • Sutherland, E. W., Robison, G. A., Butcher, R. W.: Some aspects of the biological role of adenosine 3′,5′-monophosphate (cyclic AMP). Circulation 37, 279–306 (1968).

    CAS  Google Scholar 

  • Taugner, G., Hasselbach, W.: Über den Mechanismus der Catecholamin-Speicherung in den „chromaffinen Granula“ des Nebennierenmarks. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path. 255, 266–286 (1966).

    Article  CAS  Google Scholar 

  • Trendelenburg, U.: Modification of the effect of tyramine by various agents and procedures. J. Pharmacol. exp. Ther. 134, 8–17 (1961).

    PubMed  CAS  Google Scholar 

  • Wilcken, D. E. L., Brender, D., Shorey, C. D., Macdonald, G. J.: Reserpine: Effect on structure of heart muscle. Science 157, 1332–1334 (1967).

    Article  PubMed  CAS  Google Scholar 

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von Euler, U.S. (1970). Effect of Some Metabolic Factors and Drugs on Uptake and Release of Catecholamines in vitro and in vivo. In: Schümann, HJ., Kroneberg, G. (eds) New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer-Symposium, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46241-2_14

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  • DOI: https://doi.org/10.1007/978-3-642-46241-2_14

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