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Retigeranic acid

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Total Synthesis of Natural Products

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Abstract

Retigeranic acid (1) belongs to the class of sesterterpenes, which comprise five isoprene units. The chemistry of this group of terpenes, representative examples of which are shown in Fig. 10.1 was the subject of a recent review [1]. The unique structure of retigeranic acid was undoubtedly of interest to all those who, in the late 1970s and early 1980s, participated in the development of methods for the synthesis of cyclopentanoid natural products. This particular discipline dominated an entire decade, 1978–1988, as many chemists were targeting various triquinane-containing natural products.

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Acknowledgments

The authors are grateful to the following agencies for financial support of this work: Natural Sciences and Engineering Research Council of Canada (NSERC) (Idea to Innovation and Discovery Grants), Canada Research Chair Program, Canada Foundation for Innovation (CFI), TDC Research, Inc., TDC Research Foundation, and Brock University. In addition, TH is grateful to all of the students who participated in the triquinane program at Illinois Institute of Technology (1978–1982) and Virginia Tech (1982–1992). Their names appear in the cited references.

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  1. Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario, L2S 3A1, Canada

    David R. Adams & Tomáš Hudlický

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  1. David R. Adams
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  2. Tomáš Hudlický
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Correspondence to Tomáš Hudlický .

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    Jie Jack Li

  2. , Dept. of Chemistry and Chemical Biology, Harvard University, Oxford Street 12, Cambridge, 02138, USA

    E.J. Corey

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Adams, D.R., Hudlický, T. (2012). Retigeranic acid. In: Li, J., Corey, E. (eds) Total Synthesis of Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-34065-9_10

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