Abstract
Both resting state fMRI (R-fMRI) and task-based fMRI (T-fMRI) have been widely used to study the functional activities of the human brain during task-free and task-performance periods, respectively. However, due to the difficulty in strictly controlling the participating subjectβs mental status and their cognitive behaviors during fMRI scans, it has been very challenging to tell whether or not an R-fMRI/T-fMRI scan truly reflects the participantβs functional brain states in task-free/task-performance. This paper presents a novel approach to characterizing the brainβs functional status into task-free or task-performance states. The basic idea here is that the brainβs functional state is represented by a whole-brain quasi-stable connectivity pattern (WQCP), and an effective sparse coding procedure was then applied to learn the atomic connectivity patterns (ACP) of both task-free and task-performance states based on training R-fMRI and T-fMRI data. Our experimental results demonstrated that the learned ACPs for R-fMRI and T-fMRI datasets are substantially different, as expected. However, a certain portion of ACPs from R-fMRI and T-fMRI datasets are overlap**, suggesting that those subjects with overlap** ACPs were not in the expected task-free/task-performance states during R-fMRI/T-fMRI scans.
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Zhang, X. et al. (2012). Characterization of Task-Free/Task-Performance Brain States. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds) Medical Image Computing and Computer-Assisted Intervention β MICCAI 2012. MICCAI 2012. Lecture Notes in Computer Science, vol 7511. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-33418-4_30
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DOI: https://doi.org/10.1007/978-3-642-33418-4_30
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