Abstract
In 1994, carbon ion radiotherapy (CIRT) was initiated at the National Institute of Radiological Sciences (NIRS) in Japan using the Heavy Ion Medical Accelerator in Chiba (HIMAC), which was the world’s first heavy ion accelerator complex dedicated to medical use. Among several types of ion species, carbon ions were chosen for cancer therapy because they were presumed to possess optimal properties in terms of biologically effective dose localization.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
H. Tsujii, S. Morita, T. Miyamoto, et al., Preliminary results of phase I/II carbon-ion therapy at the NIRS. J. Brachyther. Int. 13, 1–8 (1997)
S. Minohara, T. Kanai, M. Endo, et al., Respiratory gated irradiation system for heavy-ion radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 47, 1097–1103 (2000)
M. Endo, H. Koyama-Ito, S. Minohara, et al., HIPLAN - a heavy ion treatment planning system at HIMAC. J. Jpn. Soc. Ther. Radiol. Oncol. 8, 231–238 (1996)
T. Kanai, Y. Furusawa, K. Fukutsu, et al., Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy. Radiat. Res. 147, 78–85 (1997)
T. Kanai, M. Endo, S. Minohara, et al., Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44, 201–210 (1999)
J. Mizoe, H. Tsujii, T. Kamada, et al., Dose escalation study of carbon ion radiotherapy for locally advanced head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 60, 358–364 (2004)
T. Miyamoto, N. Yamamoto, H. Nishimura, et al., The working group for lung cancer: carbon ion radiotherapy for stage I non-small cell lung cancer. Radiother. Oncol. 66, 27–140 (2003)
H. Kato, H. Tsujii, T. Miyamoto, et al., Liver Cancer Working Group. Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis. Int. J. Radiat. Oncol. Biol. Phys. 59, 1468–1476 (2004)
H. Kato, S. Yamada, S. Yasuda, et al., Four-fraction carbon ion radiotherapy for hepatocellular carcinoma. Proc of 40th Ann Meeting Am Soc Clin Oncol, New Orleans, USA, June 5-8, 2004 J. Clin. Oncol. 22, 4090 (2004)
K. Akakura, H. Tsujii, S. Morita, et al., The Working Group for Genitourinary Tumors: Phase I/II clinical trials of carbon ion therapy for prostate cancer. Prostate 55, 252–258 (2004)
H. Tsuji, T. Yanagi, H. Ishikawa, et al., Working Group for Genitourinary Tumors. Hypofractionated radiotherapy with carbon ion beams for prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 32, 1153–1160 (2005)
T. Kamada, H. Tsujii, T. Yanagi, et al., Working Group for Bone and Soft Tissue Sarcomas: Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas. J. Clin. Oncol. 20, 4466–4471 (2002)
R. Imai, T. Kamada, H. Tsuji, et al., Working Group for Bone and Soft Tissue Sarcomas. Carbon ion radiotherapy for unresectable sacral chordomas. Clin. Cancer Res. 10, 5741–5746 (2004)
R. Imai, T. Kamada, H. Tsuji, et al., Working Group for Bone and Soft Tissue Sarcomas. Effect of carbon ion radiotherapy for sacral chordoma. Results of phase I-II and phase II clinical trials. Int. J. Radiat. Oncol. Biol. Phys. 77, 1470–1476 (2009)
Y. Nishida, T. Kamada, R. Imai, et al., Clinical outcome of sacral chordoma with carbon ion radiotherapy compared with surgery. Int. J. Radiat. Oncol. Biol. Phys. 79, 110–116 (2010)
S. Galandiuk, H.S. Wieand, C.G. Moertel, et al., Patterns of recurrence after curative resection of carcinoma of the colon and rectum. Surg. Gynecol. Obstet. 174, 27–32 (1992)
F. Bozzetti, L. Mariani, R. Micel, et al., Cancer of the low and middle rectum: local and distant recurrence and survival in 350 radically resected patients. J. Surg. Oncol. 62, 207–213 (1992)
J.L. McCall, M.R. Cox, D.A. Wattchow, Analysis of local recurrence rates after surgery alone for rectal cancer. Int. J. Colorectal. Dis. 10, 126–132 (1995)
H.J. Wanebo, R.J. Koness, M.P. Vezeridis, et al., Pelvic resection of recurrent rectal cancer. Ann. Surg. 220, 586–595 (1994)
D. Schulz-Ertner, C.P. Karger, A. Feuerhake, et al., Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int. J. Radiat. Oncol. Biol. Phys. 68, 449–457 (2007)
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kamada, T., Tsujii, H. (2012). HIMAC: A New Start for Heavy Ions. In: Linz, U. (eds) Ion Beam Therapy. Biological and Medical Physics, Biomedical Engineering, vol 320. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21414-1_36
Download citation
DOI: https://doi.org/10.1007/978-3-642-21414-1_36
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-21413-4
Online ISBN: 978-3-642-21414-1
eBook Packages: Physics and AstronomyPhysics and Astronomy (R0)