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Burkitt’s Acute Lymphoblastic Leukemia (L3ALL) in Adults

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Acute Leukemias

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

Accounting for 1–3% of all cases of acute lymphoblastic leukemias (ALL), Burkitt cell ALL (L3ALL) is characterized by the morphology of blast cells, the presence of monoclonal surface immunoglobulins (sIg), and by chromosomal translocations, usually t(8;14) (q24;q32) and less commonly its variants t(2;8) (p12;q24) or t(8;22) (q24;q11) [1–4]. These translocations lead to rearrangements of the protooncogene c-myc, located at band 8q24 [5]. Recently, the World Health Organization (WHO) classification of lymphoid diseases recognized the Burkitt lymphoma and the L3ALL as a single entity; a mature B-cell neoplasm with an oncogenic c-myc overexpression [6].

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  1. Service d’hématologie, Institut Gustave Roussy, Villejuif, France

    Vincent Ribrag

  2. Service d’hématologie clinique Hópital Avicennes, Université Paris XIII, Bobigny, France

    Philippe Casassus & Pierre Fenaux

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  1. Vincent Ribrag
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  2. Philippe Casassus
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  3. Pierre Fenaux
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Ribrag, V., Casassus, P., Fenaux, P. (2008). Burkitt’s Acute Lymphoblastic Leukemia (L3ALL) in Adults. In: Acute Leukemias. Hematologic Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72304-2_15

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  • DOI: https://doi.org/10.1007/978-3-540-72304-2_15

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  • Online ISBN: 978-3-540-72304-2

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