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Mesenchymal Stem Cell Based Approaches for Systemic Lupus Erythematosus Immunotherapy

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Stem Cells for Cancer and Genetic Disease Treatment

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by multi-organ involvement, with significant morbidity and mortality in young women predominantly. SLE is pathologically characterized by self-activation of auto-reactive immune responses, including activation of auto-reactive T cells and overproduction of autoantibodies by B cells. Although corticosteroids and immune-suppressants are widely used for the treatment, safer and more effective therapies are needed. The immunomodulatory properties and low immunogenic potential of mesenchymal stem cells (MSCs) make them a very promising new choice for treatment of severe refractory SLE. In this chapter, we provide a brief overview of MSCs treatment in SLE and describe current knowledge of the mechanisms by which they play parts in treating the disease, for better understanding of the pathogenesis and therapy for SLE.

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Abbreviations

APCs:

Antigen-presenting cells

B7-H1:

B7 homolog 1

BAFF:

B cell activating factor

BM:

Bone marrow

Bregs:

Regulatory B cells

DCs:

Dendritic cells

HGF:

Hepatocyte growth factor

HSCs:

Hematopoietic stem cells

IDO:

Indoleamine-2-3-dioxygenase

IFN-γ:

Interferon gamma

MMF:

Mycophenolate mofetil

MSCs:

Mesenchymal stem cells

NK cells:

Natural killer cells

NO:

Nitric oxide

NSAIDs:

Non-steroidal anti-inflammatory drugs

PGE2:

Prostaglandin E2

SLE:

Systemic lupus erythematosus

SLEDAI:

Systemic lupus erythematosus disease activity index

TGF-β:

Transforming growth factor-β

TH cells:

T helper cells

TNF-α:

Tumor necrosis factor alpha

Tregs:

Regulatory T cells

UC:

Umbilical cord

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Authors and Affiliations

  1. Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Xuexiao ** & Yang Yao

  2. Zhejiang University–University of Edinburgh Institute, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Xuexiao **

  3. Veritas Genetics Asia Inc., Hangzhou, Zhejiang, China

    Shen Lu

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  1. Xuexiao **
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  2. Shen Lu
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  3. Yang Yao
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Correspondence to Xuexiao ** .

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Editors and Affiliations

  1. Laboratory of Stem Cell Research and Application & Stem Cell Institute & Cancer Research Laboratory, VNUHCM University of Science, Ho Chi Minh City, Vietnam

    Phuc Van Pham

  2. University of Edinburgh - Zhejiang, International Campus (UoE-ZJU), Haining, Zhejiang, China

    Ahmed El-Hashash

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**, X., Lu, S., Yao, Y. (2018). Mesenchymal Stem Cell Based Approaches for Systemic Lupus Erythematosus Immunotherapy. In: Pham, P., El-Hashash, A. (eds) Stem Cells for Cancer and Genetic Disease Treatment. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-98065-2_7

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