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Cellular Aging and Tumor Regulation

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Cellular Ageing and Replicative Senescence

Part of the book series: Healthy Ageing and Longevity ((HAL))

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Abstract

Aging is the basis of most of the degenerative diseases in the elderly. These diseases can be defined as loss of function diseases. On the level of a cell, senescence can be one driving force of such diseases. In contrast, cancer is, on the one hand, associated with age as well, but can be seen as a gain of function disease. Cellular senescence can act to prevent cell proliferation and is believed to inhibit cancer growth. Interestingly, this tumor defense system can stimulate tumor formation at old age, if senescent cells start to accumulate. The connection between cellular senescence is described on the level of intracellular cell signaling as well as on the level of the immune system.

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Authors and Affiliations

  1. Heart Centre of the University Hospital Halle (Saale), Martin-Luther-University, Ernst-Grube Str. 40, 06120, Halle (Saale), Germany

    Andreas Simm

  2. Institut for Medical Immunology, Martin-Luther-University, Magdeburger Str. 2, 06112, Halle (Saale), Germany

    Barbara Seliger

  3. Department of Nutrigenomics, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Straße 29, 07743, Jena, Germany

    Lars-Oliver Klotz

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  1. Andreas Simm
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  2. Barbara Seliger
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  3. Lars-Oliver Klotz
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Correspondence to Andreas Simm .

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Editors and Affiliations

  1. Dep of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Suresh I.S. Rattan

  2. Department of Anatomy,School of Medicine, University of California, San Francisco, USA

    Leonard Hayflick

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Simm, A., Seliger, B., Klotz, LO. (2016). Cellular Aging and Tumor Regulation. In: Rattan, S., Hayflick, L. (eds) Cellular Ageing and Replicative Senescence. Healthy Ageing and Longevity. Springer, Cham. https://doi.org/10.1007/978-3-319-26239-0_11

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