Summary
Single stretch-activated (SA) cation channels have been investigated in the antiluminal membrane of freshly isolated brain capillaries. SA-channels did not distinguish between K+ and Na+ ions and were also permeable to Ca2+ and Ba2+ ions. With monovalent cations in the patch pipette the single-channel conductance was 37 pS and with the divalent cations Ba2+ and Ca2+ slope conductance was 16 and 19 pS, respectively. The open probability of the SA-channel increased with increasing negative pressure as well as with depolarization. Cell swelling induced by hypotonic shock activated the SA-channels in cell-attached experiments. The contribution of SA-channels to the regulation of cerebrospinal fluid in brain edema is discussed.
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© 1993 Birkhäuser Verlag Basel/Switzerland
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Popp, R., Hoyer, J., Gögelein, H. (1993). Mechanosensitive Nonselective Cation Channels in the Antiluminal Membrane of Cerebral Capillaries (Blood-Brain Barrier). In: Siemen, D., Hescheler, J. (eds) Nonselective Cation Channels. EXS, vol 66. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7327-7_7
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DOI: https://doi.org/10.1007/978-3-0348-7327-7_7
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