Summary
The non immunogenic mammary adenocarcinoma TS/A was transfected with the murine IL-2, IL-4, IFN-gamma genes. 3 clones releasing high levels of IL-2 or IL-4 or IFN-gamma were isolated. The ability of transfectants to form tumors after subcutaneous injection in syngeneic BALB/c mice was measured and compared to the parental TS/A (TS/A-pc) and to the cells transduced with neomicyn resistance gene alone (neo cells). All the cytokines released induced a LATI (Lymphokine-Activated Tumor Inhibition) which was more efficient after challenge with IL-2 and IL-4 transfected cells than after challenge with IFN-gamma transfected cells. The growth of a secondary contralateral challenge with TS/A-pc was significantly impaired after IL-2 and IL-4 induced tumor inhibition. The morphological data showed that the LATI rested on the recruitment of several cell reaction mechanisms, among which the ones considered as a specific seemed to predominate.
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© 1993 Springer Basel AG
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Brunetti, M. et al. (1993). Various Cytokines (IL-2, IL-4, IFN-gamma) Show Different Efficiency in Inducing Tumor Rejection. In: Cittadini, A., Baserga, R., Pinedo, H.M., Galeotti, T., Corda, D. (eds) Molecular Oncology and Clinical Applications. MCBU Molecular and Cell Biology Updates. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5663-8_27
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DOI: https://doi.org/10.1007/978-3-0348-5663-8_27
Publisher Name: Birkhäuser, Basel
Print ISBN: 978-3-0348-5665-2
Online ISBN: 978-3-0348-5663-8
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