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Cognitive Reserve: A Life-Course Perspective

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Neurobiological and Psychological Aspects of Brain Recovery

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

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Abstract

The concept of reserve has been developed to account for the discontinuity between the extent of brain damage at its clinical manifestation in the form of cognitive decline or dementia. In this chapter, we discuss contributors to cognitive reserve from various stages of the life-course, including childhood, early adulthood, middle age, and late life. Evidence from observational studies as well as intervention trials is presented and assessed. We conclude by arguing that reserve formation in dementia risk is a life-course process whereby baseline cognitive abilities are subjected to modulation by subsequent experiences at diverse stages over the entire life-course. Variations among individuals in their ability to withstand age-related brain changes are ultimately dependent on their life-time accumulation of mental, physical, and lifestyle inputs into cognitive reserve.

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Authors and Affiliations

  1. Department of Physical Activity and Health, Swedish School of Sport and Health Sciences, Stockholm, Sweden

    Rui Wang & Hui-**n Wang

  2. Aging Research Center, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institute and Stockholm University, Stockholm, Sweden

    Serhiy Dekhtyar

  3. Stress Research Institute, Department of Psychology, Stockholm University, Stockholm, Sweden

    Hui-**n Wang

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  1. Rui Wang
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  2. Serhiy Dekhtyar
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  3. Hui-**n Wang
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Correspondence to Hui-**n Wang .

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  1. Santa Lucia Foundation IRCCS, Rome, Italy

    Laura Petrosini

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Wang, R., Dekhtyar, S., Wang, HX. (2023). Cognitive Reserve: A Life-Course Perspective. In: Petrosini, L. (eds) Neurobiological and Psychological Aspects of Brain Recovery. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-031-24930-3_5

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