Cutaneous Melanoma

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Rare Tumors in Children and Adolescents

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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Abstract

Cutaneous melanoma is rare in children, but its incidence increases in adolescents. The pathogenesis of melanoma is multifactorial, making prevention important in its clinical history. The clinical management of pediatric patients with melanoma is still challenging because it is difficult to diagnose. Few studies have specifically addressed the topic of melanoma in children. Though melanoma in young patients may have particular biological characteristics, available data seem to suggest that its clinical history is similar to that of adult melanoma. The benefits of new therapies for adult melanoma have not been reflected in younger patients. There is no standard treatment for children with this tumor, and it is difficult for them to access clinical trials. More efforts (including international collaboration between pediatric and adult melanoma groups) are needed to facilitate the transfer of potentially effective new agents from adults to children and adolescents and to improve research programs dedicated to young melanoma patients.

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References

  • Aldrink JH, Selim MA, Diesen DL, Johnson J, Pruitt SK, Tyler DS, Seigler HF (2009) Pediatric melanoma: a single-institution experience of 150 patients. J Pediatr Surg 44:1514–1521

    Article  PubMed  Google Scholar 

  • Alexander A, Samlowski WE, Grossman D et al (2003) Metastatic melanoma in pregnancy: risk of transplacental metastases in the infant. J Clin Oncol 21:2179–2186

    Article  PubMed  Google Scholar 

  • Ascierto PA, McArthur GA, Dréno B et al (2016) Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial. Lancet Oncol 17(9):1248–1260

    Article  CAS  PubMed  Google Scholar 

  • Bailey KM, Durham AB, Zhao L et al (2018) Pediatric melanoma and aggressive Spitz tumors: a retrospective diagnostic, exposure and outcome analysis. Transl Pediatr 7(3):203–210

    Article  PubMed  PubMed Central  Google Scholar 

  • Barhami A, Barnhill RL (2018) Pathology and genomics of pediatric melanoma: a critical reexamination and new insights. Pediatr Blood Cancer 65(2)

    Google Scholar 

  • Bartenstein DW, Kelleher CM, Friedmann AM et al (2018) Contrasting features of childhood and adolescent melanomas. Pediatr Dermatol 35(3):354–360

    Article  PubMed  PubMed Central  Google Scholar 

  • Berk DR, LaBuz E, Dadras SS et al (2010) Melanoma and melanocytic tumors of uncertain malignant potential in children, adolescents and young adults - the Stanford experience 1995–2008. Pediatr Dermatol 27:244–254

    Article  PubMed  Google Scholar 

  • Bono A, Ferrari A (2005) Early diagnosis remains the most reliable way to cure children with melanoma. Pediatr Blood Cancer 45(3):355

    Article  PubMed  Google Scholar 

  • Brecht IB, Garbe C, Gefeller O et al (2015) 443 paediatric cases of malignant melanoma registered with the German Central Malignant Melanoma Registry between 1983 and 2011. Eur J Cancer 51(7):861–868

    Article  PubMed  Google Scholar 

  • Brecht IB, De Paoli A, Bisogno G, Orbach D, Schneider DT, Leiter U, Offenmueller S, Cecchetto G, Godzinski J, Bien E, Stachowicz-Stencel T, Ben-Ami T, Chiaravalli S, Maurichi A, De Salvo GL, Sorbara S, Bodemer C, Garbe C, Reguerre Y, Ferrari A. Pediatric patients with cutaneous melanoma: A European study. Pediatr Blood Cancer. 2018;65(6):e26974. https://doi.org/10.1002/pbc.26974. Epub 2018 Jan 19. PMID: 29350487.

  • Brenn T, McKee PHM (2008) Melanoma in children and adolescents. Diagn Histopathol 14:18–27

    Google Scholar 

  • Butter A, Hui T, Chapdelaine J, Beaunoyer M et al (2005) Melanoma in children and the use of sentinel lymph node biopsy. J Pediatr Surg 40:797–800

    Article  PubMed  Google Scholar 

  • Cancer Genome Atlas Network (2015) Genomic classification of cutaneous melanoma. Cell 161(7):1681–1696

    Article  CAS  Google Scholar 

  • Ceballos PI, Ruiz-Maldonado R, Mihm MC Jr (1995) Melanoma in children. N Engl J Med 332:656–662

    Article  CAS  PubMed  Google Scholar 

  • Cerroni L, Barnhill R, Elder D et al (2010) Melanocytic tumors of uncertain malignant potential: results of a tutorial held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008. Am J Surg Pathol 34:314–326

    Article  PubMed  Google Scholar 

  • Chao MM, Schwartz JL, Wechsler DS, Thornburg CD, Griffith KA, Williams JA (2005) High-risk surgically resected pediatric melanoma and adjuvant interferon therapy. Pediatr Blood Cancer 44:441–448

    Article  PubMed  Google Scholar 

  • Chisholm JC, Suvada J, Dunkel IJ et al (2018) BRIM-P: a phase I, open-label, multicenter, dose-escalation study of vemurafenib in pediatric patients with surgically incurable, BRAF mutation-positive melanoma. Pediatr Blood Cancer 65(5):e26947

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chuk MK et al (2017) Enrolling adolescents in disease/target-appropriate adult oncology clinical trials of investigational agents. Clin Cancer Res 23(1):9–12

    Article  PubMed  Google Scholar 

  • Cordoro KM, Gupta D, Frieden IJ, McCalmont T, Kashani-Sabet M (2013) Pediatric melanoma: results of a large cohort study and proposal for modified ABCD detection criteria for children. J Am Acad Dermatol 68:912–925

    Article  Google Scholar 

  • Crocetti E, Mallone S, Robsahm TE et al (2015) Survival of patients with skin melanoma in Europe increases further: results of the EUROCARE-5 study. Eur J Cancer 51(15):2179–2190

    Article  PubMed  Google Scholar 

  • Curtis RE, Rowlings PA, Deeg HJ et al (1997) Solid cancers after bone marrow transplantation. N Engl J Med 336:897–904

    Article  CAS  PubMed  Google Scholar 

  • Daniotti M, Ferrari A, Frigerio S et al (2009) Cutaneous melanoma in childhood and adolescence shows frequent loss of INK4A and gain of KIT. J Invest Dermatol 129(7):1759–1768

    Article  CAS  PubMed  Google Scholar 

  • Daryanani D, Plukker JT, Nap RE et al (2006) Adolescent melanoma: risk factors and long term survival. Eur J Surg Oncol 32(2):218–223

    Article  CAS  PubMed  Google Scholar 

  • Dummer R, Ascierto PA, Gogas HJ et al (2018) Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol 19(10):1315–1327

    Article  CAS  PubMed  Google Scholar 

  • Eggen CAM, Durgaram VVL, van Doorn R et al (2018) Incidence and relative survival of melanoma in children and adolescents in the Netherlands, 1989–2013. J Eur Acad Dermatol Venereol 32(6):956–961

    Article  CAS  PubMed  Google Scholar 

  • Eggermont AM, Chiarion-Sileni V, Grob JJ et al (2015) Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC18071): a randomised, double-blind, phase 3 trial. Lancet Oncol 16:522–530

    Article  CAS  PubMed  Google Scholar 

  • Eggermont AMM, Blank CU, Mandala M et al (2018) Adjuvant pembrolizumab versus placebo in resected Stage III melanoma. N Engl J Med 378(19):1789–1801

    Article  CAS  PubMed  Google Scholar 

  • Euvrard S, Kanitakis J, Claudy A (2003) Skin cancers after organ transplantation. N Engl J Med 348:1681–1691

    Article  PubMed  Google Scholar 

  • Faries MB, Thompson JF, Cochran AJ et al (2017) Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med 376(23):2211–2222. https://doi.org/10.1056/NEJMoa1613210

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferrari A, Bono A, Baldi M, Collini P, Casanova M, Pennacchioli E et al (2005) Does melanoma behave better in younger children than in adults? A retrospective study on 33 cases of childhood melanoma from a single institution. Pediatrics 115:649–654

    Article  PubMed  Google Scholar 

  • Ferrari A, Montello M, Budd T, Bleyer A (2008) The challenges of clinical trials for adolescents and young adults with cancer. Pediatr Blood Cancer 50(5 Suppl):1101–1104

    Article  PubMed  Google Scholar 

  • Ferrari A, Bisogno G, Cecchetto G et al (2014) Cutaneous melanoma in children and adolescents: the Italian Rare Tumors in Pediatric Age Project Experience. J Pediatr 164:375–382

    Article  Google Scholar 

  • Ferrari A, Brecht IB, Gatta G et al (2019) Defining and listing very rare cancers of pediatric age: consensus of the Joint Action on Rare Cancers (JARC) in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT). Eur J Cancer 110:120–126. https://doi.org/10.1016/j.ejca.2018.12.031

    Article  PubMed  Google Scholar 

  • Friedman DL, Whitton J, Leisenring W et al (2010) Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study. J Natl Cancer Inst 102:1083–1095

    Article  PubMed  PubMed Central  Google Scholar 

  • Gaspar N, Marshall LV, Binner D et al (2018) Joint adolescent–adult early phase clinical trials to improve access to new drugs for adolescents with cancer: proposals from the multi-stakeholder platform—ACCELERATE. Ann Oncol 29(3):766–771

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Geoerger B, Bergeron C, Gore L et al (2017) Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma. Eur J Cancer 86:358–363

    Article  CAS  PubMed  Google Scholar 

  • Gerami P, Jewell SS, Morrison LE et al (2009) Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol 33:1146–1156

    Article  PubMed  Google Scholar 

  • Gerami P et al (2013) Risk assessment for atypical spitzoid melanocytic neoplasms using FISH to identify chromosomal copy number aberrations. Am J Surg Pathol 37(5):676–684

    Article  PubMed  Google Scholar 

  • Gershenwald JE, Scolyer RA, Hess KR et al (2017) Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin 67(6):472–492

    Article  PubMed  PubMed Central  Google Scholar 

  • Han D, Zager JS, Han G et al (2012) The unique clinical characteristics of melanoma diagnosed in children. Ann Surg Oncol 19:3888–3895

    Article  PubMed  PubMed Central  Google Scholar 

  • Handfield-Jones SE, Smith NP (1996) Malignant melanoma in childhood. Br J Dermatol 134:607–616

    Article  CAS  PubMed  Google Scholar 

  • Hauschild A, Grob J, Demidov LV et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380(9839):358–365

    Article  CAS  PubMed  Google Scholar 

  • Hayward NK (2003) Genetics of melanoma predisposition. Oncogene 22:3053–3062

    Article  CAS  PubMed  Google Scholar 

  • Hodi FS, O’Day SJ, McDermott DF et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711–723

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Howman-Giles R, Shaw HM, Scolyer RA et al (2010) Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients. Ann Surg Oncol 17:138–143

    Article  PubMed  Google Scholar 

  • Jafarian F, Powell J, Kokta V et al (2005) Malignant melanoma in childhood and adolescence: report of 13 cases. J Am Acad Dermatol 53:816–822

    Article  PubMed  Google Scholar 

  • Jansen B, Hansen D, Moy R et al (2018) Gene expression analysis differentiates melanomas from Spitz nevi. J Drugs Dermatol 17(5):574–576

    CAS  PubMed  Google Scholar 

  • Kalani N, Guidry JA, Farahi JM et al (2019) Pediatric melanoma: characterizing 256 cases from the Colorado Central Cancer Registry. Pediatr Dermatol 36(2):219–222. https://doi.org/10.1111/pde.13747

    Article  PubMed  Google Scholar 

  • Karlsson PM, Fredrikson M (2007) Cutaneous malignant melanoma in children and adolescents in Sweden, 1993–2002: the increasing trend is broken. Int J Cancer 121:323–328

    Article  CAS  PubMed  Google Scholar 

  • Kaste SC, Pappo AS, Jenkins JJ III, Pratt CB (1996) Malignant melanoma in children: imaging spectrum. Pediatr Radiol 26:800–805

    Article  CAS  PubMed  Google Scholar 

  • Kleinerman RA, Tucker MA, Tarone RE et al (2005) Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol 23:2272–2279

    Article  PubMed  Google Scholar 

  • Lallas A, Kyrgidis A, Ferrara G et al (2014) Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review. Lancet Oncol 15(4):178–183

    Article  Google Scholar 

  • Lam PH, Obirieze AC, Ortega G et al (2018) An age-based analysis of pediatric melanoma: staging, surgery and mortality in the surveillance, epidemiology and end results database. Am Surg 84(5):739–745

    Article  PubMed  Google Scholar 

  • Lange JR, Palis BE, Chang DC, Soong S-J, Balch CM (2007) Melanoma in children and teenagers: an analysis of patients from the National Cancer Data Base. J Clin Oncol 25:1363–1368

    Article  PubMed  Google Scholar 

  • Larkin J, Chiarion-Sileni V, Gonzalez R et al (2015) Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373(1):23–34

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lauper JM, Krause A, Vaughan TL, Monnat RJ Jr (2013) Spectrum and risk of neoplasia in Werner syndrome: a systematic review. PLoS One 8(4):e59709

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lazovich D, Vogel RI, Berwick M, Weinstock MA, Anderson KE, Warshaw EM (2010) Indoor tanning and risk of melanoma: a case-control study in a highly exposed population. Cancer Epidemiol Biomark Prev 19:1557–1568

    Article  Google Scholar 

  • Lee S et al (2015) TERT promoter mutations are predictive of aggressive clinical behavior in patients with spitzoid melanocytic neoplasms. Sci Rep 5:11200

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leiter U, Garbe C (2008) Epidemiology of melanoma and nonmelanoma skin cancer - the role of sunlight. Adv Exp Med Biol 624:89–103

    Article  PubMed  Google Scholar 

  • Leiter U, Stadler R, Mauch C et al (2016) Complete lymph node dissection versus no dissection in patients with sentinel lymph node biopsy positive melanoma (DeCOG-SLT): a multicentre, randomised, phase 3 trial. Lancet Oncol 17(6):757–767. https://doi.org/10.1016/S1470-2045(16)00141-8

    Article  PubMed  Google Scholar 

  • Leman JA, Evans A, Mooi W, Mackie RM (2005) Outcomes and pathological review of a cohort of children with melanoma. Br J Dermatol 152(6):1321–1323

    Article  CAS  PubMed  Google Scholar 

  • Livestro DP, Kaine EM, Michaelson JS et al (2007) Melanoma in the young: differences and similarities with adult melanoma: a case-matched controlled analysis. Cancer 110:614–624

    Article  PubMed  Google Scholar 

  • Long GV, Stroyakovskiy D, Gogas H et al (2015) Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial. Lancet 386(9992):444–451

    Article  CAS  PubMed  Google Scholar 

  • Long GV, Hauschild A, Santinami M et al (2017) Adjuvant dabrafenib plus trametinib in stage III BRAF-mutated melanoma. N Engl J Med 377(19):1813–1823

    Article  CAS  PubMed  Google Scholar 

  • Lu C, Zhang J, Nagahawatte P et al (2015) The genomic landscape of childhood and adolescent melanoma. J Invest Dermatol 135(3):816–823

    Article  CAS  PubMed  Google Scholar 

  • Makkar HS, Frieden IJ (2004) Neurocutaneous melanosis. Semin Cutan Med Surg 23:138–144

    Article  PubMed  Google Scholar 

  • Margaryan NV, Gilgur A, Seftor EA et al (2016) Melanocytes affect nodal expression and signaling in melanoma cells: a lesson from pediatric large congenital melanocytic nevi. Int J Mol Sci 17(3):418

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Massi D, Tomasini C, Senetta R et al (2015) Atypical Spitz tumors in patients younger than 18 years. J Am Acad Dermatol 72(1):37–46

    Article  PubMed  Google Scholar 

  • McArthur GA, Chapman PB, Robert C et al (2014) Safety and efficacy of vemurafenib in BRAFV600E and BRAFV600 K mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol 15(3):323–332

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Melanoma Treatment (PDQ®): Health Professional Version. (n.d.) PDQ Adult Treatment Editorial Board. PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–2018 Feb 2

    Google Scholar 

  • Merchant MS, Wright M, Baird K et al (2016) Phase I clinical trial of ipilimumab in pediatric patients with advanced solid tumors. Clin Cancer Res 22(6):1364–1370

    Article  CAS  PubMed  Google Scholar 

  • Milton GW, Shaw HM, Thompson JF, McCarthy WH (1997) Cutaneous melanoma in childhood: incidence and prognosis. Australas J Dermatol 38:44–48

    Article  Google Scholar 

  • Mocellin S, Verdi D, Nitti D (2009) DNA repair gene polymorphisms and risk of cutaneous melanoma: a systematic review and meta-analysis. Carcinogenesis 30(10):1735–1743

    Article  CAS  PubMed  Google Scholar 

  • Mocellin S, Pasquali S, Rossi CR, Nitti D (2010) Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis. J Natl Cancer Inst 102:493–501

    Article  CAS  PubMed  Google Scholar 

  • Momper JD, Mulugeta Y, Green DJ et al (2007) Adolescent dosing and labeling since the Food and Drug Administration Amendments Act of 2007. JAMA Pediatr 167:926–932

    Article  Google Scholar 

  • Mones JM, Ackerman AB (2003) Melanomas in prepubescent children. Review comprehensively, critique historically, criteria diagnostically, and course biologically. Am J Dermatopathol 25:223–238

    Article  PubMed  Google Scholar 

  • Moore-Olufemi S, Herzog C, Warneke C et al (2011) Outcomes in pediatric melanoma: comparing prepubertal to adolescent pediatric patients. Ann Surg 253:1211–1215

    Article  PubMed  Google Scholar 

  • Moscarella E, Zalaudek I, Cerroni L et al (2012) Excised melanocytic lesions in children and adolescents - a 10-year survey. Br J Dermatol 167:368–373

    Article  CAS  PubMed  Google Scholar 

  • Mu E, Lange JR, Strouse JJ (2012) Comparison of the use and results of sentinel lymph node biopsy in children and young adults with melanoma. Cancer 118(10):2700–2707

    Article  PubMed  Google Scholar 

  • Muftuoglu M, Oshima J, von Kobbe C, Cheng WH, Leistritz DF, Bohr VA (2008) The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis. Hum Genet 124:369–377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Navid F, Furman WL, Fleming M et al (2005) The feasibility of adjuvant interferon alpha-2b in children with high-risk melanoma. Cancer 103:780–787

    Article  CAS  PubMed  Google Scholar 

  • Navid F, Herzog CE, Sandoval J et al (2016) Feasibility of pegylated interferon in children and young adults with resected high-risk melanoma. Pediatr Blood Cancer 63(7):1207–1213

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Offenmueller S, Leiter U, Bernbeck B et al (2017) Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP). Klin Padiatr 229(6):322–328

    Article  PubMed  Google Scholar 

  • Pappo AS (2003) Melanoma in children and adolescents. Eur J Cancer 39:2651–2661

    Article  CAS  PubMed  Google Scholar 

  • Paradela S, Fonseca E, Pita-Fernandez S et al (2010) Prognostic factors for melanoma in children and adolescents: a clinicopathologic, single-center study of 137 patients. Cancer 116:4334–4344

    Article  PubMed  Google Scholar 

  • Paraiso KHT, Fedorenko IV, Cantini LP et al (2010) Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer 102(12):1724–1730

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pearce MS, Parker L, Cotterill SJ et al (2003) Skin cancer in children and young adults: 28 years’ experience from the Northern Region Young Person’s Malignant Disease Registry, UK. Melanoma Res 13(4):421–426

    Article  PubMed  Google Scholar 

  • Printz C (2015) Sun behaviors and genes may affect future melanoma risk. Cancer 121(8):1157

    PubMed  Google Scholar 

  • Quéreux G, Dréno B (2011) Fotemustine for the treatment of melanoma. Expert Opin Pharmacother 12(18):2891–2904

    Article  PubMed  CAS  Google Scholar 

  • Réguerre Y, Vittaz M, Orbach D et al (2016) Cutaneous malignant melanoma in children and adolescents treated in pediatric oncology units. Pediatr Blood Cancer 63(11):1922–1927

    Article  PubMed  CAS  Google Scholar 

  • Ribas A, Puzanov I, Dummer R et al (2015) Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol 16:908–918

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rose K, Grant-Kels JM (2018) Most adolescents’ melanomas are conventional malignant adult-type melanomas. Eur J Cancer 95:117–119

    Article  PubMed  Google Scholar 

  • Seynnaeve B et al (2017) Genetic and epigenetic alterations of TERT are associated with inferior outcome in adolescent and young adult patients with melanoma. Sci Rep 7:45704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shah NC, Gerstle JT, Start M et al (2006) Use of sentinel lymph node biopsy and high-dose interferon in pediatric patients with high-risk melanoma: the Hospital for Sick Children experience. J Pediatr Hematol Oncol 28:496–500

    Article  PubMed  Google Scholar 

  • Spatz A, Ruiter D, Hardmeier T et al (1996) Melanoma in childhood: an EORTC-MCG multicenter study on the clinico-pathological aspects. Int J Cancer 68(3):317–324

    Article  CAS  PubMed  Google Scholar 

  • Spitz S (1948) Melanomas of childhood. Am J Pathol 24:591–609

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sreeraman Kumar R, Thapa R, Kim Y, Khushalani NI, Sondak VK, Reed DR (2018) Higher than reported adolescent and young adult clinical trial enrollment during the “Golden Age” of melanoma clinical trials. Cancer Med 7(4):991–996

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Strouse JJ, Fears TR, Tucker MA, Wayne AS (2005) Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J Clin Oncol 23:4735–4741

    Article  PubMed  Google Scholar 

  • Svedman FC, Pillas D, Taylor A et al (2016) Stage-specific survival and recurrence in patients with cutaneous malignant melanoma in Europe – a systematic review of the literature. Clin Epidemiol 8:109–122

    Article  PubMed  PubMed Central  Google Scholar 

  • Whiteman DC, Milligan A, Welch J et al (1997) Germline CDKN2A mutations in childhood melanoma. J Natl Cancer Inst 89:1460

    Article  CAS  PubMed  Google Scholar 

  • Wilmott JS, Johansson PA, Newell F et al (2019) Whole genome sequencing of melanomas in adolescent and young adults reveals distinct mutation landscapes and the potential role of germline variants in disease susceptibility. Int J Cancer 144(5):1049–1060

    Article  CAS  PubMed  Google Scholar 

  • Tricoli JV, Blair DG, Anders CK et al (2016) Biologic and clinical characteristics of adolescent and young adult cancers: acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma. Cancer 122(7):1017–1028

    Article  PubMed  Google Scholar 

  • Zuckerman R, Maier JP, Guiney WB Jr et al (2001) Pediatric melanoma: confirming the diagnosis with sentinel node biopsy. Ann Plast Surg 46:394–399

    Article  CAS  PubMed  Google Scholar 

  • Woulters MW, Michielin O, Bastiaannet E et al (2018) ECCO essential requirements for quality cancer care: melanoma. Crit Rev Oncol Hematol 122:164–178

    Google Scholar 

  • Wechsler J, Bastuji-Garin S, Spatz A et al (2002) Reliability of the histopathologic diagnosis of malignant melanoma in childhood. Arch Dermatol 138(5):625–628

    Article  PubMed  Google Scholar 

  • Tatiana KSC, Somers GR, Pope E, Zuker RM (2010) Predisposing factors and outcomes of malignant skin tumors in children. Plast Reconstr Surg 126:508–514

    Article  CAS  Google Scholar 

  • Weber JS, D’Angelo SP, Minor D et al (2015) Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 16:375–384

    Article  CAS  PubMed  Google Scholar 

  • Wolchok JD, Chiarion-Sileni V, Gonzalez R et al (2017) Overall survival with combined nivolumab and ipilimumab in advanced melanoma. N Engl J Med 377:1345–1356

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wong JR, Harris JK, Rodriguez-Galindo C, Johnson KJ. Incidence of childhood and adolescent melanoma in the United States: 1973-2009. Pediatrics. 2013 May;131(5):846-54.

    Google Scholar 

  • Weber J, Mandala M, Del Vecchio M et al (2017) Adjuvant nivolumab versus ipilimumab in resected stage III or IV melanoma. N Engl J Med 377:1824–1835

    Article  CAS  PubMed  Google Scholar 

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Indini, A., Pappo, A.S., Eigentler, T.K., Collini, P., Ferrari, A. (2022). Cutaneous Melanoma. In: Schneider, D.T., Brecht, I.B., Olson, T.A., Ferrari, A. (eds) Rare Tumors in Children and Adolescents. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-92071-5_40

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