Abstract
Various components of the inflammatory cascade like cytokines, chemokines, adhesion molecules, and receptors are highly expressed in asthma. These proteins are not generally expressed in normal cells. This augmentation in their expression during the inflammatory process of asthma is due to the enhanced gene transcription induced in a cell-specific manner. This modulation in the expression of these genes is regulated by specific proteins called transcription factors which execute this process by binding to the specific DNA segments. So, transcription factors play a crucial role in asthma pathogenesis. Many transcription factors like STAT6, GATA3, NF-κB, and AP-1 are of prime importance in differentiating Th2 cells and therefore represent significant targets for asthma therapy. Various small molecule inhibitors or biologics that work via transcription factors are under investigation and several others (such as glucocorticoids) are already in clinical use (Caramori et al. 2008, 2004; Barnes 2006; Rayees et al. 2014).
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Rayees, S., Din, I. (2021). Transcription Factor Modulators. In: Asthma: Pathophysiology, Herbal and Modern Therapeutic Interventions. SpringerBriefs in Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-70270-0_9
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