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Coronaviruses as Vaccine Vectors for Veterinary Pathogens

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Viral Vectors in Veterinary Vaccine Development

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Abstract

Coronaviruses (CoVs, family Coronaviridae) are enveloped, plus-stranded RNA viruses that can cause highly contagious upper respiratory diseases in humans and animals with potentially fatal outcomes. Typical symptoms found in chickens infected with infectious bronchitis coronavirus (IBV) include coughing, sneezing, gas**, nasal discharge and tracheal rales. Animal CoVs also cause local epidemics and pandemics with high infection rates, significantly increasing the economic burden on the poultry and livestock industry. With the realization that animal CoVs can be transmitted to humans, these viruses are now considered a global health threat. Improvement in technologies, such as reverse genetics, has conferred the ability to manipulate coronaviral genomes in the development of antiviral intervention and as vaccine vectors against other veterinary pathogens. This chapter summarizes new information on CoV reverse genetics and advances in vaccine development.

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Authors and Affiliations

  1. Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, People’s Republic of China

    Ding **ang Liu & To Sing Fung

  2. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

    Yan Ling Ng

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  1. Ding **ang Liu
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  2. Yan Ling Ng
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  3. To Sing Fung
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Editors and Affiliations

  1. School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia

    Thiru Vanniasinkam

  2. VIDO-InterVac & School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada

    Suresh K. Tikoo

  3. Department of Veterinary Medicine, University of Maryland, College Park, College Park, MD, USA

    Siba K. Samal

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Liu, D.X., Ng, Y.L., Fung, T.S. (2021). Coronaviruses as Vaccine Vectors for Veterinary Pathogens. In: Vanniasinkam, T., Tikoo, S.K., Samal, S.K. (eds) Viral Vectors in Veterinary Vaccine Development. Springer, Cham. https://doi.org/10.1007/978-3-030-51927-8_10

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