DDU-Nets: Distributed Dense Model for 3D MRI Brain Tumor Segmentation

  • Conference paper
  • First Online:
Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries (BrainLes 2019)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 11993))

Included in the following conference series:

Abstract

Segmentation of brain tumors and their subregions remains a challenging task due to their weak features and deformable shapes. In this paper, three patterns (cross-skip, skip-1 and skip-2) of distributed dense connections (DDCs) are proposed to enhance feature reuse and propagation of CNNs by constructing tunnels between key layers of the network. For better detecting and segmenting brain tumors from multi-modal 3D MR images, CNN-based models embedded with DDCs (DDU-Nets) are trained efficiently from pixel to pixel with a limited number of parameters. Postprocessing is then applied to refine the segmentation results by reducing the false-positive samples. The proposed method is evaluated on the BraTS 2019 dataset with results demonstrating the effectiveness of the DDU-Nets while requiring less computational cost.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
EUR 29.95
Price includes VAT (Germany)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
EUR 42.79
Price includes VAT (Germany)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
EUR 53.49
Price includes VAT (Germany)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-GBM collection. The Cancer Imaging Archive (2017)

    Google Scholar 

  2. Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-LGG collection. The Cancer Imaging Archive 286 (2017)

    Google Scholar 

  3. Bakas, S., et al.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. In: Scientific Data (2017)

    Google Scholar 

  4. Bakas, S., et al.: Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the brats challenge. ar**v preprint ar**v:1811.02629 (2018)

  5. Cao, H., Bernard, S., Heutte, L., Sabourin, R.: Improve the performance of transfer learning without fine-tuning using dissimilarity-based multi-view learning for breast cancer histology images. In: Campilho, A., Karray, F., ter Haar Romeny, B. (eds.) ICIAR 2018. LNCS, vol. 10882, pp. 779–787. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-93000-8_88

    Chapter  Google Scholar 

  6. Dong, H., Yang, G., Liu, F., Mo, Y., Guo, Y.: Automatic brain tumor detection and segmentation using U-Net based fully convolutional networks. In: Valdés Hernández, M., González-Castro, V. (eds.) MIUA 2017. CCIS, vol. 723, pp. 506–517. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-60964-5_44

    Chapter  Google Scholar 

  7. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  8. Huang, G., Liu, Z., Van Der Maaten, L., Weinberger, K.Q.: Densely connected convolutional networks. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 4700–4708 (2017)

    Google Scholar 

  9. Isensee, F., Kickingereder, P., Wick, W., Bendszus, M., Maier-Hein, K.H.: No new-net. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 234–244. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_21

    Chapter  Google Scholar 

  10. Larsson, G., Maire, M., Shakhnarovich, G.: FractalNet: ultra-deep neural networks without residuals. ar**v preprint ar**v:1605.07648 (2016)

  11. Li, X., Chen, H., Qi, X., Dou, Q., Fu, C.W., Heng, P.A.: H-DenseUNet: hybrid densely connected UNet for liver and tumor segmentation from CT volumes. IEEE Trans. Med. Imaging 37(12), 2663–2674 (2018)

    Article  Google Scholar 

  12. Mamelak, A.N., Jacoby, D.B.: Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601). Expert Opin. Drug Deliv. 4(2), 175–186 (2007)

    Article  Google Scholar 

  13. Menze, B.H., et al.: The multimodal brain tumor image segmentation benchmark (brats). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2014)

    Article  Google Scholar 

  14. Myronenko, A.: 3D MRI brain tumor segmentation using autoencoder regularization. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 311–320. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_28

    Chapter  Google Scholar 

  15. Pleiss, G., Chen, D., Huang, G., Li, T., van der Maaten, L., Weinberger, K.Q.: Memory-efficient implementation of DenseNets. ar**v preprint ar**v:1707.06990 (2017)

  16. Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hanxiao Zhang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Zhang, H., Li, J., Shen, M., Wang, Y., Yang, GZ. (2020). DDU-Nets: Distributed Dense Model for 3D MRI Brain Tumor Segmentation. In: Crimi, A., Bakas, S. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2019. Lecture Notes in Computer Science(), vol 11993. Springer, Cham. https://doi.org/10.1007/978-3-030-46643-5_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-46643-5_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-46642-8

  • Online ISBN: 978-3-030-46643-5

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics

Navigation