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A Preteen Female with Fatigue and Incidental Finding of Thrombocytopenia

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Pediatric Bleeding Disorders

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Abstract

Chronic immune thrombocytopenia (ITP) is defined much the same as acute ITP, aside from the duration of thrombocytopenia, which is to exceed 12-month duration, without another identifiable cause. Consideration for underlying etiologies for chronic thrombocytopenia, such as inherited thrombocytopenia disorders, as well as evaluation of secondary causes of ITP, as in immune dysregulation disorders, immunodeficiencies, chronic infections, or autoimmune diseases, should be based on clinical features and family history. In addition to cutaneous bleeding, a clinically significant non-bleeding complaint is fatigue. Treatment options include the same first-line therapies that are utilized in acute ITP, as well as immunomodulatory agents, thrombopoietin receptor agonists (TPO-RA), and in some cases splenectomy.

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Author information

Authors and Affiliations

  1. Nationwide Children’s Hospital, Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Columbus, OH, USA

    Melissa J. Rose & Amanda Jacobson-Kelly

  2. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA

    Melissa J. Rose & Amanda Jacobson-Kelly

Authors
  1. Melissa J. Rose
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  2. Amanda Jacobson-Kelly
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Correspondence to Melissa J. Rose .

Editor information

Editors and Affiliations

  1. Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, USA

    Amy L. Dunn

  2. Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, USA

    Bryce A. Kerlin

  3. Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, USA

    Sarah H. O'Brien

  4. Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, USA

    Melissa J. Rose

  5. Division of Pediatric Hematology, Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, Columbus, OH, USA

    Riten Kumar

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Rose, M.J., Jacobson-Kelly, A. (2020). A Preteen Female with Fatigue and Incidental Finding of Thrombocytopenia. In: Dunn, A., Kerlin, B., O'Brien, S., Rose, M., Kumar, R. (eds) Pediatric Bleeding Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-31661-7_14

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  • DOI: https://doi.org/10.1007/978-3-030-31661-7_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-31660-0

  • Online ISBN: 978-3-030-31661-7

  • eBook Packages: MedicineMedicine (R0)

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