Abstract
Despite progress in the treatment of disseminated non-seminomatous germ cell tumors (NSGCT), 20–30%of patients do not achieve CR or relapse [1]. We evaluated high-dose chemotherapy (HDC) followed by autologous bone-marrow transplantation (ABMT) in selected poor-prognosis NSGCT patients. These patients were young, had a chemosensitive tumor with a well-established dose-response relationship [7–10] and rare bone marrow involvement [2]. The HDC associated Cisplatin, Etoposide and Cyclophosphamide (PEC protocol) were used; Carboplatin recently replaced Cisplatin in a pilot study.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Bosl GJ, Gluckman R, Geller N, Golbey RB, Whitmore WF, Herr H, Sogani P, Morse M, Martini N, Bains M, McCormac P (1986) VAB-6: An effective chemotherapy regimen for germ cell tumors. J Clin Oncol 4: 1493–1499
Pico JL, Droz JP, Ostronoff M, Baume D, Gouyette A, Beaujean F, Hayat M (1989) Proceedings of the Fourth International Symposium (ed) The University of Texas MD Anderson Cancer Center: high-dose chemotherapy with autologous bone marrow transplantation for poor prognosis non-seminomatous germ cell tumors
Droz JP, Kramar A, Ghosn M, Piot G, Rey A, Theodore C, Wibault P, Court BH, Perrin JL, Travagli JP, Bellet D, Caillaud JM, Pico JL, Hayat M (1988) Prognostic factors in advanced non-seminomatous testicular cancer. Cancer 62: 564–568
Nichols CR, Tricot G, Williams SD, Van Besien K, Loehrerp J, Roth BJ, Akard L, Hoffman R, Goulet R, Wolff SN, Giannone L, Greer J, Einhorn LH, Jansen J (1989) Dose-intensive chemotherapy in refractory germ cell cancer — A phase I/II trial of high-dose carboplatin and etoposide with autologous bone marrow transplantation. J Clin Oncol 7: 932–939
Ozols RF, Ihde DC, Lineman WM, Jacob J, Ostchega Y, Young RC (1988) A randomized trial of standard chemotherapy versus a high-dose chemotherapy regimen in the treatment of poor prognosis non-seminomatous germ cell tumors. J Clin Oncol 6: 1031–1040
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag France
About this paper
Cite this paper
Pico, J.L. et al. (1991). High-dose chemotherapy with hematologic rescue for high-risk non-seminomatous germ cell tumors. In: Banzet, P., Holland, J.F., Khayat, D., Weil, M. (eds) Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy. Springer, Paris. https://doi.org/10.1007/978-2-8178-0782-9_76
Download citation
DOI: https://doi.org/10.1007/978-2-8178-0782-9_76
Publisher Name: Springer, Paris
Print ISBN: 978-2-8178-0784-3
Online ISBN: 978-2-8178-0782-9
eBook Packages: Springer Book Archive