Transcription, RNA Processing, and Translation

  • Chapter
Introduction to Bioinformatics

Abstract

The processes of transcription, RNA processing (in eukaryotes), and translation constitute the pathway that leads to the conversion of genetic information in the linear sequence of bases in genomic DNA into the linear amino acid sequences of functional proteins. Thus, DNA undergoes transcription to synthesize a primary RNA transcript, which in eukaryotes undergoes RNA processing to produce a mature messenger RNA (mRNA), then mRNAs are translated into functional polypeptides. Each of these cellular processes will be described below.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Suggested Reading

Transcription and RNA Processing

  • Cramer, P., Bushnell, D. A, Fu, J., Gnatt, A. L., et al. (2000) Architecture of RNA polymerase II and implications for the transcription mechanism, Science 288, 640–649.

    Article  PubMed  CAS  Google Scholar 

  • Cramer, P., Bushnell, D. A., and Kornberg, R. D. (2001) Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution, Science 292, 1863–1876.

    Article  PubMed  CAS  Google Scholar 

  • deHaseth, P. L., Zupancic, M. L., Record, M. T. (1998) RNA polymerase-promoter interactions: The comings and goings of RNA polymerase, J. Bacteriol. 180, 3019–3025.

    PubMed  CAS  Google Scholar 

  • Hirose, H. and Manley, J. L. (2000) RNA polymerase II and the integration of nuclear events, Genes Dev. 14, 1415–1429.

    PubMed  CAS  Google Scholar 

  • Lee, T. I. and Young, R. A. (2000) Transcription of eukaryotic protein-coding genes, Annu. Rev. Genet. 34, 77–137.

    Article  CAS  Google Scholar 

  • Mooney, R. A., Artsimovitch, I., and Landick, R. (1998) Information processing by RNA polymerase: Recognition of regulatory signals during RNA chain elongation, J. Bacteriol. 180, 3265–3275.

    PubMed  CAS  Google Scholar 

Translation

  • Garret, R. A., Douthwaite, S. R., Liljas, A., Matheson, A. T., Moore, P. B., and NoIler, H. F. (2000) The Ribosome: structure, function, antibiotics and cellular interactions, ASM Press, Washington, DC.

    Google Scholar 

  • Gutell R. R. (1996) Comparative Sequence Analysis and the Structure of 16S and 23S rRNA, in: Ribosomal RNA. Structure, Evolution, Processing, and Function in Protein Biosynthesis, (Dahlberg, A. and Zimmerman, B. eds.) CRC Press, Boca Raton, FL, pp. 111–128.

    Google Scholar 

  • Yusupova, G. Z., Yusupov, M. M., Cate, J. H., and Noller, H. F. (2001) The path of messenger RNA through the ribosome, Cell 106, 233–241.

    Article  PubMed  CAS  Google Scholar 

  • Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H., and Noller, H. F. (2001) Crystal structure of the ribosome at 5.5 A resolution, Science 292, 883–896.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Yang, T.P., O’Brien, T.W. (2003). Transcription, RNA Processing, and Translation. In: Krawetz, S.A., Womble, D.D. (eds) Introduction to Bioinformatics. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-335-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-335-4_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-58829-241-4

  • Online ISBN: 978-1-59259-335-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Navigation