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Germ-Free Mice and Lymphocyte Differentiation

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Germ-Free Biology Experimental and Clinical Aspects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 3))

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Abstract

Lymphocytes have been the object of intensive study for the last fifty years, (1) yet we know surprisingly little about them. Our ignorance is based in part on difficulties in locating individual members of a circulating cell population in vivo and attempting to ascribe functions to heterogeneous cells in the complex organs which provide a matrix for their differentiation. The word, lymphocyte, is a term loosely applied to a family of cells which differ in size, morphology, anatomical location and function. Small, medium and large lymphocytes are found ubiquitously throughout the body, but in particular in bone marrow, thymus, lymph nodes, and spleen. To compound difficulties further, the morphological resemblance of one group of lymphocytes to another has been corroborated by physical studies, such as size distribution in electronic cell counters and distribution in density gradients. Thus lymphocytes comprise a group of cells which vary from 6 to 25 microns in diameter (1) and between 1.06 and 1.07 in buoyant density (2).

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Author information

Authors and Affiliations

  1. Department of Health, Roswell Park Memorial Institute, New York State, Buffalo, New York, USA

    Ben W. Papermaster

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  1. Ben W. Papermaster
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Editor information

Editors and Affiliations

  1. Roswell Park Memorial Institute, New York State Department of Health, State University of New York, Buffalo, New York, USA

    Edwin A. Mirand

  2. Canisius College, Niagara University, Niagara University, New York, Buffalo, New York, USA

    Edwin A. Mirand

  3. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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Papermaster, B.W. (1969). Germ-Free Mice and Lymphocyte Differentiation. In: Mirand, E.A., Back, N. (eds) Germ-Free Biology Experimental and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 3. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6495-3_50

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  • DOI: https://doi.org/10.1007/978-1-4899-6495-3_50

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6234-8

  • Online ISBN: 978-1-4899-6495-3

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