Abstract
IL-12 has been reported to have antitumoral activity in different mouse tumors. In this study IL-12 was tested on the in vivo growth of H5V cells, a tumor line obtained by polyoma middle T (PmT) infection of mouse endothelial cells (Garlanda et al., P.N.A.S., 91:7291, 1994). H5V injection in syngeneic hosts causes vascular tumors that may represent an experimental model for human opportunistic vascular tumors. T lymphocytes, mainly CD8, and Th1 cytokines have been shown to play a major role in the in vivo resistance to H5V to H5V tumor; IFNγ and TGFb1 display antitumoral activity, mainly in immunocompetent hosts.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer Science+Business Media New York
About this chapter
Cite this chapter
Fioretti, F., Dong, Q.G., Fusco, M., Vecchi, A., Mantovani, A. (1998). Antitumor Activity of IL-12 in a Mouse Opportunistic Vascular Tumor: Role of Immunocompetent Cells and Cytokines. In: Catravas, J.D., Callow, A.D., Ryan, U.S. (eds) Vascular Endothelium. NATO ASI Series, vol 294. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0133-0_27
Download citation
DOI: https://doi.org/10.1007/978-1-4899-0133-0_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-0135-4
Online ISBN: 978-1-4899-0133-0
eBook Packages: Springer Book Archive