Abstract
Administration of choline (Ch) or lecithin (phosphatidylcholine), the biosynthetic precursors of acetylcholine (ACh) may increase functional cholinergic neurotransmission (1,14,15). Ch has been reported to increase plasma levels of Ch and brain levels of ACh (1, 14,15) and to be of some benefit in the treatment of tardive dyskinesia (7,11,12). Lecithin is similar but may be superior insofar as it does not cause one of the major side effects of Ch treatment, namely, an offensive “fishy” odor.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Barbeau, A., Growden, J. H. and Wurtman, R. J. (eds)(1979): Choline and Lecithin in Brain Disorders, Raven Press, New York.
Boyd, W.D., Graham-White, J., Blackwood, G., Glen, I. and McQueen, J. (1977): Lancet 2:711.
Casamenti, F., Mantovani, P., Amaducci, L. and Pepeu, E. (1979): J. Neurochem. 32:529–533.
Davies, P. and Maloney, A.J.F. (1976): Lancet 2:1403.
Davies, P. and Verth, A.H. (1978): Brain Res. 138:385–392.
Davis, K. and Yamamura, H.I. (1978): Life Sci. 23:1729–1734.
Davis, K.L., Hollister, L.E., Barehas, J.D. and Berger, P.A.(1976): Life Sci. 19:1507–1516.
Deutsch, J.A. (1971): Science 174:788–794.
Drachman, D.A. (1977): Neurology 27:783–790.
Glen, A. I. M. and Whalley, L. J. (ed)(1979): Alzheimer’s Disease: Recognition of Potentially Reversible Deficits, Churchill- Livingstone, Edinburgh.
Growdon, J.H., Gelenberg, A.J., Doller, J., Hirsh, M.J. and Wurtman, R.J. (1978): New Eng. J. Med. 298:1029–1030.
Growdon, J.H., Hirsch, M.J., Wurtman, R.J. and Weiner, W.(1977): New Eng. J. Med. 297:524–527.
Hanin, I. and Goldberg, A.M. (1976): IN Biology of Cholinergic Function, Appendix 1 (eds) A. M. Goldberg and I. Hanin, Raven Press, New York, pp. 647–654.
Haubrich, D.R. and Chippendale, T.J. (1977): Life Sci. 20: 1465–1478.
Hirsch, M.J. and Wurtman, R.J. (1978): Science 202:223–225.
Mohs, R.C., Davis, K.C., Tinklenberg, J.R., Pfefferbaum, A., Hollister, L.E. and Kopell, B.S. (1979): IN Brain Acetylcholine and Neuropsychiatric Disease (eds) K. L. Davis and P. A. Berger, Plenum Press, New York, pp.
Mohs, R.C. and Davis, K.L. (1979): IN Alzheimer’s Disease: Recognition of Potentially Reversible Deficits (eds) A. I. M. Glen and L. J. Whalley, Churchill-Livingstone, Edinburgh, pp. 154–158.
Perry, E.K., Perry, R.H., Blessed, G. and Tomlinson, B.E. (1978): Neuropathol. Appl. Neurobiol. 4:273–277.
Reisine, T.D., Bird, E.D., Spokes, E., Enna, J. and Yamamura, H.I. (1978): Trans. Amer. Soc. Neurochem. 9:203.
Sitaram, N., Weingartner, H. and Gillin, J.C. (1978): Science 201:274–276.
Sitaram, N., Weingartner, H., Caine, E. D. and Gillin, J. C.:Life Sci. 22:1555–1560.
Sitaram, N., Weingartner, H. and Gillin, J.C. (1979): IN Nutrition and the Brain (eds) A. Barbeau, J. H. Growdon, and R. J. Wurtman, Raven Press, New York, pp. 367–375.
Smith, C. and Swash, M. (1979): First Intl. Study Group in Pharmacol, of Memory Disorders Assoc. with Aging: Presentation
Signoret, J. C., Whiteley, A. and Thermittee, C. (1978): Lancet 2:837.
Weingartner, H., Sitaram, N. and Gillin, J.C. (1979): Bull. Psychonomic Soc. 13:9–11
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Plenum Press, New York
About this chapter
Cite this chapter
Gillin, J.C., Sitaram, N., Weingartner, H., Crammer, C., Hanin, I. (1981). Effects of Lecithin on Memory and Plasma Choline Levels: A study in Normal Volunteers. In: Pepeu, G., Ladinsky, H. (eds) Cholinergic Mechanisms. Advances in Behavioral Biology, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8643-8_92
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8643-8_92
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8645-2
Online ISBN: 978-1-4684-8643-8
eBook Packages: Springer Book Archive