Abstract
It has been hypothesized (Nelson et al., 1988, Samsel et al., 1988, Bredle et al. 1989), that sepsis is a disorder of microvascular regulation resulting in decreased O2 transport from the capillaries to the mitochondria. Evidence for this hypothesis was offered by Nelson et al. (1988), who found greater levels of systemic and intestinal critical O2 transport (TO2), defined as the minimum TO2 required to maintain constant O2 consumption (VO2), in hypovolemic septic dogs when compared to a control group. This phenomenon may be related to increases in microcirculatory heterogeneity, resulting in a mismatch of tissue perfusion and cellular O2 needs. This is manifested at the organ level by decreases in O2 extraction capacity.
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References
Archer, L.T., 1985, Myocardial dysfunction in endotoxin and E.Coli induced shock: pathophysiological mechanisms. Circ. Shock 15:261.
Bredle, D.L., Samsel, R.W., Schumaker, P.T., and Cain, S.M., 1989, Critical O2 delivery to skeletal muscle at high and low PO2 in endotoxemic dogs. J. Appl. Physiol. 66:2553.
Cain S.M., 1986, Assessment of tissue oxygenation. Crit. Care Clin. 2:537.
Chaudry, I.H., Wichterman, K.A., and Baue, A.E., 1979, Effect of sepsis on tissue adenine nucleotide levels. Surgery 85:205.
Clowes, G.H.A., O’Donnell, T.F., Ryan, N.T., and Blackburn, G.L., 1974, Energy metabolism in sepsis: Treatment based on different patterns in shock and high output stage. Ann. Surg. 179:684.
Grisham, M.B., Everse, J., and Janssen H.F., 1988, Endotoxemia and neutrophil activation in vivo. Am. J. Physiol. 254:H1017.
Gutierrez, G., 1986, The rate of oxygen release and its effect on capillary O2 tension: A mathematical analysis. Respir. Physiol. 63:79.
Gutierrez, G., Warley, A.R., and Dantzker, D.R., 1986, Oxygen delivery and utilization in hypothermic dogs. J. Appl. Physiol. 60:751.
Gutierrez, G., Lund, N., Acero, A.L., and Marini C., 1989, The relationship of venous PO2 to muscle PO2 during hypoxemia. J. Appl. Physiol. (In Press).
Houtchens, B.A. and Westenskow, D.R., 1984, Oxygen Consumption in Septic Shock: Collective Review. Circ. Shock. 13:361.
Kessler M, Hoper J, Krumme BA., 1976, Monitoring of tissue perfusion and cellular function. Anesthesiology 45:184.
Kilpatrick-Smith, L., and Erecinska, M., 1983, Cellular effects of endotoxin in vitro. I.- Effect of endotoxin on mitochondrial substrate metabolism and intracellular calcium. Circ. Shock. 11:85.
Lund, N., Odman S., and Lewis D.H., 1980, Skeletal muscle pressure fields in rats. A study of the normal state and the effects of local anesthetics, local trauma, and hemorrhage. Acta Anaesth. Scand. 24:155.
Lund, N., 1978, Methods for measuring tissue oxygen tension. Acta Anaesth. Scand. suppl. 70:183.
Meyrick, B. and Brigham, K.L., 1983, Acute effects of Escherichia coli endotoxin in the pulmonary microcirculation of anesthetized sheep: structure-function relationships. Lab. Invest. 48:458.
Musch, T.I. and Larach, D.R., 1988, O2 contents of blood sampled from different venous compartments of the rat. J. Appl. Physiol. 65:988.
Nelson D.P., Samsel, R.W., Wood, L.D.H., and Schumacker, P.T., 1988, Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia. J. Appl. Physiol. 64: 2410.
Novotny, M.J., Laughlin, M.H., and Adams, H.R., 1988, Evidence for lack of importance of oxygen free radicals in Escherichia coli endotoxemia in dogs. Am. J. Physiol. 254:H954.
Odman, S. and Lund, N., 1980, Data acquisition and information processing in MDO oxygen electrode measurements of tissue oxygen pressure. Acta Anaesth. Scand. 24:161.
Otis, A.B., 1964, Quantitative relationships in steady-state gas exchange, in: “Handbook of Physiology, Vol 1: Respiration.” Am Physiol Soc, Washington D.C.
Parrillo, J.E., 1985, Cardiovascular disfunction in septic shock: new insights into a deadly desease. Intl. J. Cardiol. 7:314.
Piiper, J., Meyer, M., and Scheid, P., 1984, Dual role of diffusion in tissue gas exchange: Blood tissue equilibration and diffusion shunt. Respir. Physiol. 56:131.
Samsel, R.W., Nelson, D.P., Sanders, W.M., Wood, L.D.H., and Schumacker, P.T., 1983, Effect of endotoxin on systemic and skeletal muscle O2 extraction. J. Appl. Physiol. 65:1377.
Zar, J.H., 1984, “Biostatistical Analysis. (2nd Ed.)”, Prentice Hall, Englewood Cliffs.
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© 1990 Plenum Press, New York
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Gutierrez, G., Lund, N., Palizas, F., Acero, A. (1990). Skeletal Muscle PO2 during Hypodynamic Sepsis. In: Piiper, J., Goldstick, T.K., Meyer, M. (eds) Oxygen Transport to Tissue XII. Advances in Experimental Medicine and Biology, vol 277. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8181-5_63
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DOI: https://doi.org/10.1007/978-1-4684-8181-5_63
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