Abstract
Medizinische Kernklinik und Poliklinik Universitäts-Krankenhaus Eppendorf MartinistraGe 52 D-2000 Hamburg 20, FRG Receptor-mediated endocytosis is well-recognized as a general mechanism used by many cells to take up biologically important molecules. The variety of ligands taken up by receptor-mediated endocytosis includes hormones (e.g. epidermal growth factor (EGF) and insulin), transport proteins carrying nutritional substances (e.g., lipoproteins and transferrin), asialoglycoproteins (ASGPs) and immunoglobulins (Goldstein, Anderson et al. 1979). The terminal catabolism of most plasma lipoproteins and asialoglycoproteins occurs chiefly in the liver by means of receptor-mediated endocytosis (Havel and Hamilton 1988).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Angelin, B., C. A. Raviola, T. L. Innerarity and R. W. Mahley. (1983). “Regulation of hepatic lipoprotein receptors in the dog; rapid regulation of apolipoprotein B,E receptors, but not of apolipoprotein E receptors, by intestinal lipoproteins and bile acids.”J.CIin.lnvest. 71: 816–831.
Arbeeny, C. M. and V. A. Rifici. (1984). “The uptake of chylomicron remnants and very low density lipoprotein remnants by the perfused rat liver.”J.Biol.Chem. 259: 9662–9666.
Belcher, J. D., R. L. Hamilton, S. E. Brady, C. A. Hornick, S. Jaeckle, W. J. Schneider and R. J. Havel. (1987). “Isolation and characterization of three endosomal fractions from the liver of estradioltreated rats.”Proc.Natl.Acad.Sci.USA. 84: 6785–6789.
Chao, Y. -s., A. L. Jones, G. T. Hradek, E. E. T. Windier and R. J. Havel. (1981). “Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats.”Proc.Natl.Acad.Sci.USA. 78: 597–601.
Dunn, W. A. and A. L. Hubbard. (1984). “Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver:ligand and receptor dynamics.”J.Cell Biol. 98: 2148–2159.
Dunn, W. A., T. P. Connoly and A. L. Hubbard. (1986). “Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes:receptor pathway.”J. Cell Biol. 102:24–36.
Geuze, H. J., J. W. Slot, G. J. A. M. Strous, H. F. Lodish and A. L. Schwartz. (1983). “Intracellular site of asialoglycoprotein receptor-ligand uncoupling:doublelable immunoelectron microscopy during receptor-mediated endocytosis.”Cell. 32: 277–287.
Geuze, H. J., J. W. Slot and A. L. Schwartz. (1987). “Membranes of sorting organelles display lateral heterogeneity in receptor distribution.”J.Cell Biol. 104: 1715–1723.
Goldstein, J. L., R. G. W. Anderson and M. S. Brown. (1979). “Coated pits, coated vesicles, and receptor-mediated endocytosis.”Nature. 279: 679–685.
Havel, R. J., N. Yamada and D. M. Shames. (1987). “Role of apolipoprotein E in lipoprotein metabolism.”Am.Heart J. 113:470–474.
Havel, R. J. and R. L. Hamilton. (1988). “Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism.”Hepatology. 8: 1689–1704.
Jaeckle, S., S. E. Brady and R. J. Havel. (1989). “Membrane binding sites for plasma lipoproteins on endosomes from rat liver.”Proc.Natl.Acad.Sci.USA. 86:1880–1884.
Jaeckle, S., S. Miranda-Brady and R. J. Havel. (1990). “Dynamics of epidermal growth factor and its receptor in three hepatic endosomal fractions.”submitted for publication.
Jaeckle, S. and R. J. Havel. (1990). Unpublished data
Jones, A. L, G. T. Hradek, C. Hornick, G. Renaud, E. E. T. Windier and R. J. Havel. (1984). “Uptake and processing of remnants of chylomicrons and very low density lipoproteins by rat liver.”J.Lipid Res. 25: 1151–1158.
Kita, T., J. L. Goldstein, M. S. Brown, Y. Watanabe, C. A. Hornick and R. J. Havel. (1982). “Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.”Proc.Natl.Acad.Sci.USA. 79: 3623–3627.
Lai, W. H., P. H. Cameron, I. Wada, J. -. Doherty, D. G. Kay, B. I. Posner and J. J. M. Bergeron. (1989). “Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo.”J.Cell Biol. 109: 2741–2749.
Lund, H., K. Takahashi, R. L. Hamilton and R. J. Havel. (1989). “Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liver.”Proc.Natl.Acad.Sci.USA. 86: 9318–9322.
Soutar, A. K., K. Harders-Spengel, D. P. Wade and B. L. Knight. (1986). “Detection and quantitation of low density lipoprotein (LDL) receptors in human liver ligand blotting, immunoblotting, and radioimmunoassay; LDL receptor protein content is correlated with plasma LDL cholesterol concentration.”J.Biol.Chem. 261: 17127–17133.
Wall, D. A. and A. L. Hubbard. (1980). “The galactose-specific recognition system of mammalian liver: the route of ligand internalization in rat hepatocytes.”Cell. 21: 79–93.
Windier, E., Y. -. Chao and R. J. Havel. (1980a). “Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.”J.Biol.Chem. 255: 5475–5480.
Windier, E., Y. -. Chao and R. J. Havel. (1980b). “Regulation of the hepatic uptake of triglyceriderich lipoproteins in the rat; opposing effects of homologous apoprotein E and individual C apoproteins.”J.Biol.Chem. 255: 8303–8307.
Windier, E. E. T., P. T. Kovanen, Y. -. Chao, M. S. Brown, R. J. Havel and J. L. Goldstein. (1980). “The estradiol-stimulated lipoprotein receptor of rat liver; a binding site that mediates the uptake of rat lipoproteins containing apoprotein B and E.”J.Biol.Chem. 255(21): 10464–10471.
Windier, E. and R. J. Havel. (1985). “Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver.”J.Lipid Res. 26: 556–565.
Windier, E. E. T., S. Preyer and H. Greten. (1986). “Influence of lysophosphatidylcholine on the Capoprotein content of rat and human triglyceride-rich lipoproteins during triglyceride hydrolysis.”J.CIin.lnvest. 78: 658–665.
Windier, E. E. T., J. Greeve, W. H. Daerr and H. Greten. (1988). “Binding of rat chylomicrons and their remnants to the hepatic low-density-lipoprotein receptor and its role in remnant removal.”J.Biol.Chem. 252:553–561.
Windier, E., J. Greeve, B. Levkau, V. Kolb-Bachofen, W. Daerr and H. Greten. (1990). “The human asialoglycoprotein-receptor: a possible binding site for LDL and chylomicron remnants.”submitted for publication.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Jäckle, S. et al. (1990). The Endocytosis of Lipoproteins by the Liver and their Intracellular Pathway in Comparison to other Ligands. In: Malmendier, C.L., Alaupovic, P., Brewer, H.B. (eds) Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics. Advances in Experimental Medicine and Biology, vol 285. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5904-3_38
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5904-3_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5906-7
Online ISBN: 978-1-4684-5904-3
eBook Packages: Springer Book Archive