Abstract
Trauma to a skeletal muscle may be experimentally induced by various types of injury. This results in the necrosis of the injured muscle fibers followed by the degradation of cell debris and subsequent regeneration. Revascularization and the presence at the site of injury of myogenic stem cells, the “satellite” cells, are essential for the regeneration to take place (Allbrook 1981; Carlson and Faulkner, 1983). This sequence of degeneration — regeneration is observed in many genetically inherited myopathies among which the most dramatic is Duchenne Muscular Dystrophy. Conspicuous foci of necrosis and regeneration are common in young patients and although active regeneration occurs particularly in the earlier stages of the disease, it is ineffective in preventing fiber loss and progression of the disease (Cullen and Mastaglia 1980). This leads to the replacement of the muscle fibers by a fibro-fatty tissue at more advanced stages of the disease and is accompanied by progressive weakness due to necrosis and loss of muscle fibers.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Alameddine H., Dehaupas M., Fardeau M., Régénération musculaire par autogreffe de cellules satellites multipliées in vitro. C. R. Acad. Sc. 304: 493, 1987.
Allbrook D., Skeletal muscle regeneration. Muscle and Nerve 4: 234, 1981.
Carlson B.M., Faulkner J.A., The regeneration of skeletal muscle fibers following injury: a review. Med. Sci. Sport Exer. 15: 187, 1983.
Carlson B.M., Gutmann E., Regeneration in grafts of normal and denervated muscle in the rat: morphology and histochemistry. Anat. Rec. 183: 47, 1975.
Cullen M.J., Mastaglia F.L., Morphological changes in dystrophic muscles. Brit. Med. Bull. 36: 145, 1980.
Hoffman E.P., Brown R.H., Kunkel L.M., Dystrophin: the protein product of the Duchenne Muscular dystrophy locus. Cell 51: 919, 1987.
Kunkel L.M., Monaco A.P., Mieddlesworth W., Ochs H.D., Latt S.A., Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion. Proc. Natl. Acad. Sci. USA 82: 4778, 1985.
Monaco A.P., Bertelson C.J., Middlesworth W., Colleti C.A., Aldridge J., Fischbeck K.M., Bartlett R., Pericak-Vance M.A., Roses A.D., Kunkel L.M., Detection of deletions spaning in the Duchenne muscular dystrophy gene. Nature 323: 646, 1985.
Sloper J.C., Partridge T.A., Skeletal muscle: regeneration and transplantation. Brit. Med. Bull. 36: 153, 1980.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Alameddine, H.S., Fardeau, M. (1990). Regeneration of Skeletal Muscle Induced by Satellite Cell Grafts. In: Griggs, R.C., Karpati, G. (eds) Myoblast Transfer Therapy. Advances in Experimental Medicine and Biology, vol 280. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5865-7_18
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5865-7_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5867-1
Online ISBN: 978-1-4684-5865-7
eBook Packages: Springer Book Archive