Abstract
Calcium-pum** membrane ATPases play the essential function of terminating Ca2+-dependent responses. Two broad classes of Ca2+-pum** ATPases are now known to exist in animal cells, those of internal membranes (100 kDa) and the plasma membrane enzymes (120–140 kDa). These two families of Ca2+-pum** ATPases differ substantially in molecular, enzymatic and regulatory properties commensurate with their differiential localization and physiological roles. Recent studies in a number of laboratories have provided evidence that multiple isoforms of each type of Ca2+ -ATPase are produced in different cell types as products of either differential splicing events or different genes. These sets of isoforms are almost certain to have subtle differences in functional properties related to the requirements of a particular biological setting.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Benaim, G., Zurini, M., and Carafoli, E. (1984). J. Biol. Chem. 259: 8471–8477.
Billingsley, M.E., Pennypacker, K.R., Hoover, C.G., Brigati, D.J., and Kincaid, R.L. (1985). Proc. Nat’l. Acad. Sci. (USA). 82: 7585–7589.
Brandt, P., Zurini, M., Sisken, B.F., Rhoads, R.E. and Vanaman, T.C. (1987). in Calcium Binding Proteins In Health and Disease, eds. Norman, A.N., Means, A.R. and Vanaman, T.C. (Academic Press), pp. 544–554.
Brandt, P., Zurini, M., Neve, R.L., Rhoads, R.E., and Vanaman, T.C. (1988). Proc. Nat’l. Acad. Sci. (USA). 85: 2914–2918.
Burnette, W.N. (1981). Anal. Biochem. 112, 195–203.
Cotman, C.W. (1974). In: Methods in Enzymology 31, 445–452.
James, P., Maeda, M., Fisher, R., Verma, A.K., Krebs, J., Penniston, J.T., and Carafoli, E. (1988). J. Biol. Chem. 263: 2905–2910.
Laemmli, U. (1970). Nature (Lond.) 227, 680–685.
Mann, D.M., and Vanaman, T.C. (1989). J. Biol. Chem. (in press).
Morrissey, J.H. (1981). Anal. Biochem. 117, 307–310.
Neve, R.L., Harris, P., Kosik, K.S., Kurnit, D.M. and Donlon, T.A. (1986). Mol. Brain Res. 1, 271–280.
Niggli, V., Penniston, J.T., and Carafoli, E. (1979). J. Biol. Chem. 254, 9955–9958.
Shull, G.E., and Greeb, J. (1988). J. Biol. Chem. 263, 8646–8657.
Verma, A.K., Filoteo, A.G., Stanford, D.R., Wieben, E.D., Penniston, J.T., Strehler, E.E., Fischer, R., Heim, R., Vogel, G., Mathews, S., Strehler-Page, M.-A., James, P., Vorherr, T., Krebs, J., and Carafoli, E. (1988). J. Biol. Chem. 263, 14152–14159.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Mann, D.M., Brandt, P., Sisken, B., Vanaman, T.C. (1989). Identification of a Synaptic Membrane-Localized Isoform of the Calcium-Pum** ATPase. In: Hidaka, H., Carafoli, E., Means, A.R., Tanaka, T. (eds) Calcium Protein Signaling. Advances in Experimental Medicine and Biology, vol 255. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5679-0_8
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5679-0_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5681-3
Online ISBN: 978-1-4684-5679-0
eBook Packages: Springer Book Archive