Abstract
Treatment options are limited for patients with disseminated carcinoma of the breast whose disease has progressed after therapy with standard chemotherapeutic programs (1). In fact, the usefulness of testing investigational agents in those breast cancer patients who have been heavily pretreated, (two or more prior regimens), has been questioned recently (2). Thus, the discovery of effective therapy for this patient population is of considerable interest.
This study was supported by Cancer Center Support Grant CA-33572 and by Lederle Laboratories. Requests for reprints should be addressed to J. Doroshow, M.D., Department of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010. These results, in part, have been reported previously in Proc. Amer. Soc. Clin. Oncol. 5:65, 1986.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
I. C. Henderson, D. F. Hayes, S. Come, J. R. Harris, and G. Canellos, New agents and new medical treatments for advanced breast cancer, Sem. in Onc. 14:34 (1987).
E. Estey, D. Hoth, R. Simon, S. Marsoni, B. Leyland- Jones, and R. Wittes, Therapeutic response in phase I trials of antineoplastic agents, Cancer Treat. Rep. 70: 1105 (1986).
J. A. Houghton, C. Schmidt, and P. J. Houghton, The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts, Eur. J. Cancer Clin. Oncol. 18: 347 (1982).
M. B. Yin, S. F. Zakrzewski, and M. T. Hakala, Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil, Mol. Pharmacol. 23: 190 (1983).
R. M. Evans, J. D. Laskin, and M. T. Hakala, Effects of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil, Cancer Res. 41: 3288 (1981).
J. H. Doroshow, M. Bertrand, E. Newman, P. Multhauf, L. Leong, D. Blayney, D. Goldberg, K. Margolin, B. Carr, S. Akman, and G. Metter, Preliminary analysis of a randomized comparison of 5-fluorouracil and high-dose continuous-infusion folinic acid in disseminated colorectal cancer, NCI Monogr. 5: 171 (1987).
J. R. Anderson, L. Bernstein, and M. C. Pike, Approximate confidence intervals for probabilities of survival and quantiles in life-table analysis, Biometrics38: 407 (1982).
J. R. Harris, S. Hellman, G. P. Canellos, and B. Fisher, Cancer of the breast, in: “Cancer: Principles and Practice of Oncology,” V. T. DeVita, Jr., S. Hellman, and S. A. Rosenberg, eds., J. B. Lippincott Co., Philadelphia (1985).
G. Marini, E. Simonicini, A. Zaniboni, F. Gorni, P. Marpicati, and A. Zambruni, 5-fluorouracil and high-dose folinic acid as salvage treatment of advanced breast cancer: an update, Oncology 44: 336 (1987).
C. J. Allegra, B. A. Chabner, P. W. Sholar, C. Bagley, J. C. Drake, and M. E. Lippman, NCI Monogr. 5: 199 (1987).
G. B. Mann, G. N. Hortobagyi, A. Buzdar, H-Y. Yap, and M. Valdivieso, A comparative study of PALA, PALA plus 5-FU, and 5-FU in advanced breast cancer, Cancer 56: 1320 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Doroshow, J.H. et al. (1988). Effective Salvage Therapy for Refractory Disseminated Breast Cancer with 5-Fluorouracil and High-Dose Continuous Infusion Folinic Acid. In: Rustum, Y., McGuire, J.J. (eds) The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology, vol 244. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5607-3_26
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5607-3_26
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-5609-7
Online ISBN: 978-1-4684-5607-3
eBook Packages: Springer Book Archive