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The Role of Glutathione S-Transferases in Drug Resistance

  • Chapter
Alternative Mechanisms of Multidrug Resistance in Cancer

Abstract

Chemotherapy, in specific clinical settings, is an effective modality of cancer chemotherapy. Failure of a chemotherapeutic regimen to induce a response may be due to many different factors. Foremost among these is the inability of the drugs to reach the critical cellular target. In this regard, physiological factors may play a large role in the successful outcome of therapy: absorption, distribution, metabolism, and elimination are key principles in successful cancer chemotherapy. Whether the resistance is intrinsic or acquired, it is necessary to understand the underlying molecular mechanisms in order to devise rational therapeutic approaches aimed at circumventing the resistance. Studies carried out using cultured tumor cell models and other systems have established that a variety of mechanisms can contribute to drug resistance (Bellamy et al., 1994; Woolley and Tew, 1988). The glutathione S-transferases (GSTs) may play an important role in protecting the cell from the toxic effects of a wide variety of electrophilic compounds including herbicides, insecticides, and carcinogens as well as antineoplastic agents (Beckett and Hayes, 1993; Hayes and Wolf, 1988). This chapter will focus on our current understanding of the involvement of these enzymes in drug resistance and as tumor markers. In addition, potential means of manipulating these proteins in order to affect the outcome of cancer chemotherapy will be discussed.

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Authors
  1. William T. Bellamy
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  1. Sunnybrook Health Science Center, University of Toronto, Toronto, Canada, M4N 3M5

    John A. Kellen

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© 1995 Birkhäuser Boston

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Bellamy, W.T. (1995). The Role of Glutathione S-Transferases in Drug Resistance. In: Kellen, J.A. (eds) Alternative Mechanisms of Multidrug Resistance in Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4615-9852-7_2

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  • DOI: https://doi.org/10.1007/978-1-4615-9852-7_2

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